A Potentially Deleterious Role of IGFBP-2 on Bone Density in Aging Men and Women

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

Sex Steroids and the Construction and Conservation of the Adult Skeleton

2002 • 1,688 citations

History of the Rochester Epidemiology Project

1996 • 1,479 citations

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*

1997 • 1,056 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

1999 • 1,008 citations

Relationship of Serum Sex Steroid Levels and Bone Turnover Markers with Bone Mineral Density in Men and Women: A Key Role for Bioavailable Estrogen1

1998 • 915 citations

Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*

1980 • 752 citations

Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities

2000 • 633 citations

Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*

1988 • 606 citations

IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

2002 • 434 citations

Estrogen and the Male Skeleton

2002 • 299 citations

Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods

1996 • 261 citations

Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study1

1998 • 256 citations

Insulin-like Growth Factors and Bone: The Osteoporosis Connection

1994 • 229 citations

Plasma concentrations of free and non-TeBG bound testosterone in women on oral contraceptives

1974 • 222 citations

Serum Levels of Insulin-like Growth Factor (IGF) I, IGF-Binding Protein (IGFBP)-2, and IGFBP-3 in Osteoporotic Patients with and without Spinal Fractures

1997 • 190 citations

Insulin-Like Growth Factor-I in Men with Idiopathic Osteoporosis¹

1997 • 189 citations

Insulin-Like Growth Factors I and II: Aging and Bone Density in Women*

1984 • 178 citations

Low plasma levels of insulin‐like growth factor 1 (IGF‐1) in male patients with idiopathic osteoporosis

1992 • 175 citations

Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women.

1996 • 156 citations

Specifying the cellular responses to IGF signals: roles of IGF-binding proteins

2002 • 152 citations

Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men

1994 • 140 citations

Novel Aspects of the Insulin-like Growth Factor Binding Proteins

1999 • 136 citations

Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells.

1995 • 131 citations

Insulin-Like Growth Factors and Bone: The Osteoporosis Connection Revisited

1998 • 122 citations

Growth hormone-dependent insulin-like growth factor binding protein is a major determinant of bone mineral density in healthy men

1994 • 116 citations

Insulin-Like Growth Factor-I in Men with Idiopathic Osteoporosis

1997 • 114 citations

The measurement of sex steroid binding globulin by differential ammonium sulphate precipitation

1973 • 107 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific.

1992 • 104 citations

Gender Differences in Insulin-like Growth Factor and Bone Mineral Density Association in Old Age: The Rancho Bernardo Study

1998 • 99 citations

Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults.

1998 • 93 citations

Obesity, and bone strength and “mass”: A tutorial based on insights from a new paradigm

1997 • 93 citations

Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: Implications for bone loss with aging

1995 • 93 citations

Relationship Between Baseline Insulin‐Like Growth Factor‐I (IGF‐I) and Femoral Bone Density in Women Aged Over 70 Years: Potential Implications for the Prevention of Age‐Related Bone Loss

1996 • 91 citations

Effects of Androgens on the Insulin-Like Growth Factor System in an Androgen-Responsive Human Osteoblastic Cell Line

1999 • 86 citations

Osteoporosis and bone functional adaptation: mechanobiological regulation of bone architecture in growing and adult bone, a review.

2000 • 73 citations

Estrogen Effects on Insulin-Like Growth Factor Gene Expression in a Human Osteoblastic Cell Line with High Levels of Estrogen Receptor

1998 • 70 citations

Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

2002 • 69 citations

Bone Mineral Density in Femoral Neck is Positively Correlated to Circulating Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein (IGFBP)-3 in Swedish Men

2002 • 67 citations

Determinants of Bone Mineral Density and Spinal Fracture Risk in Postmenopausal Japanese Women

2001 • 59 citations

Insulin-like growth factors and osteoporosis

1997 • 56 citations

Insulin-Like Growth Factors and Skeletal Growth: Possibilities for Therapeutic Interventions

1999 • 52 citations

Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions

2000 • 51 citations

The Role of Insulin-like Growth Factors and Binding Proteins in Bone Cell Biology

2002 • 43 citations

Effects of Recombinant Human Insulin-Like Growth Factor (IGF)-I and Estrogen Administration on IGF-I, IGF Binding Protein (IGFBP)-2, and IGFBP-3 in Anorexia Nervosa: A Randomized-Controlled Study

2003 • 34 citations

Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein.

1995 • 31 citations

Low serum concentrations of insulin‐like growth factor I are associated with femoral bone loss in a population‐based sample of postmenopausal women

2001 • 30 citations

Modulation of the Effects of Glucocorticoids on Collagen Synthesis in Fetal Rat Calvariae by Insulin-like Growth Factor Binding Protein-2

1997 • 29 citations

Insulin-like growth factor I (IGF-I) serum level modifications during transdermal estradiol treatment in postmenopausal women: A possible bimodal effect depending on basal IGF-I values

1998 • 22 citations

Potential Role of rhIGF-I/IGFBP-3 in Maintaining Skeletal Mass in Space

1998 • 20 citations

Serum insulin-like growth factor binding protein profiles in postmenopausal women: Their correlation with bone mineral density

1996 • 19 citations

Growth and growth hormone secretion at puberty: the role of gonadal steroid hormones.

1992 • 14 citations