Bone Morphogenetic Protein-2 Promotes Osteoblast Apoptosis through a Smad-independent, Protein Kinase C-dependent Signaling Pathway

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Bone: Formation by Autoinduction

1965 • 5,498 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*

2000 • 2,226 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

1998 • 1,705 citations

Principles of Bone Biology

2019 • 1,699 citations

Principles of Bone Biology

1997 • 1,367 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

The Bcl-2 Protein Family

2000 • 793 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

Serine/Threonine Protein Kinases and Apoptosis

2000 • 692 citations

The bone morphogenetic protein family and osteogenesis

1992 • 686 citations

Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines

1998 • 585 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot

1998 • 441 citations

Transcriptional control of osteoblast growth and differentiation

1996 • 426 citations

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development

1998 • 412 citations

The Mitochondrion in Cell Death Control: Certainties and Incognita

2000 • 404 citations

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1999 • 388 citations

Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor

1998 • 373 citations

Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts

1994 • 328 citations

Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

1998 • 319 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Signaling by Fibroblast Growth Factors (Fgf) and Fibroblast Growth Factor Receptor 2 (Fgfr2)–Activating Mutations Blocks Mineralization and Induces Apoptosis in Osteoblasts

2000 • 301 citations

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation

1997 • 282 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

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Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor ?1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation

1999 • 254 citations

BMP2-induced Apoptosis Is Mediated by Activation of the TAK1-p38 Kinase Pathway That Is Negatively Regulated by Smad6

2000 • 242 citations

Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines

1998 • 227 citations

Differential Inhibition of Smad6 and Smad7 on Bone Morphogenetic Protein- and Activin-mediated Growth Arrest and Apoptosis in B Cells

1999 • 225 citations

Smad1 and Smad5 Act Downstream of Intracellular Signalings of BMP-2 That Inhibits Myogenic Differentiation and Induces Osteoblast Differentiation in C2C12 Myoblasts

1997 • 224 citations

Multiple Extracellular Signals Promote Osteoblast Survival and Apoptosis¹

1997 • 217 citations

Proliferation and Differentiation of Human Osteoblastic Cells Associated with Differential Activation of MAP Kinases in Response to Epidermal Growth Factor, Hypoxia, and Mechanical Stressin Vitro

1998 • 205 citations

Bone morphogenetic protein-2 and transforming growth factor-β2 interact to modulate human bone marrow stromal cell proliferation and differentiation

1998 • 158 citations

Msx2 Is a Transcriptional Regulator in the BMP4-Mediated Programmed Cell Death Pathway

1997 • 153 citations

Tumor necrosis factor-α and interleukin-1β increase the Fas-mediated apoptosis of human osteoblasts

1999 • 151 citations

Involvement of ERK in BMP-2 Induced Osteoblastic Differentiation of Mesenchymal Progenitor Cell Line C3H10T1/2

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Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily

1995 • 137 citations

Genetic control of cell differentiation in the skeleton

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Internucleosomal dna fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud

1993 • 113 citations

Ectopic Expression ofMsx-2in Posterior Limb Bud Mesoderm Impairs Limb Morphogenesis While InducingBMP-4Expression, Inhibiting Cell Proliferation, and Promoting Apoptosis

1998 • 105 citations

Retinoic acid regulates programmed cell death through BMP signalling

1999 • 103 citations

Regulation of Alkaline Phosphatase Activity by p38 MAP Kinase in Response to Activation of Gi Protein-Coupled Receptors by Epinephrine in Osteoblast-Like Cells¹

1999 • 102 citations

Protein kinase C involvement in apoptosis

1995 • 99 citations

Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea.

1998 • 87 citations

Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud

1998 • 84 citations

Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis

1997 • 82 citations

Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts

2001 • 80 citations

Increased Osteoblast Apoptosis in Apert Craniosynostosis

2001 • 79 citations

Activation of Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase and p38 Kinase in Calphostin C-induced Apoptosis Requires Caspase-3-like Proteases but Is Dispensable for Cell Death

1999 • 79 citations

Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation

1999 • 79 citations

N‐ and E‐cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein‐2

2000 • 79 citations

Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C

1993 • 75 citations

Sutural Morphogenesis in the Mouse Calvaria: The Role of Apoptosis

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N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2

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Bone Morphogenetic Proteins Regulate Interdigital Cell Death in the Avian Embryo

1999 • 68 citations

Bone Morphogenetic Proteins Induce Apoptosis and Growth Factor Dependence of Cultured Sympathoadrenal Progenitor Cells

1998 • 63 citations

Protein kinase signalling pathways involved in the up-regulation of the rat α1(I) collagen gene by transforming growth factor β1 and bone morphogenetic protein 2 in osteoblastic cells

1999 • 61 citations

Apoptosis

1999 • 58 citations

Expression and phorbol ester–induced down-regulation of protein kinase C isozymes in osteoblasts

1996 • 58 citations

Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells.

1994 • 55 citations

The Bone Morphogenetic Protein 2 Signaling Mediator Smad1 Participates Predominantly in Osteogenic and not in Chondrogenic Differentiation in Mesenchymal Progenitors C3H10T½

2000 • 55 citations

Osteoblasts and Bone Formation

1998 • 46 citations

Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line

1999 • 42 citations

Experimental Induction ofBMP-4Expression Leads to Apoptosis in the Paraxial and Lateral Plate Mesoderm

1998 • 38 citations

Modulation of apoptosis of proliferating and differentiating HL-60 cells by protein kinase inhibitors: suppression of PKC or PKA differently affects cell differentiation and apoptosis

1999 • 27 citations

Implication of Protein Kinase C in IL-2-Mediated Proliferation and Apoptosis in a Murine T Cell Clone

1994 • 24 citations

Apoptotic Cell Death During Normal Embryogenesis of the Coronal Suture

1997 • 21 citations