Integrins and Their Ligands

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 962 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

1991 • 771 citations

Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments.

1991 • 755 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia

1981 • 639 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Structure and Function of Leukocyte Integrins

1990 • 620 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Amino acid sequence of the human fibronectin receptor.

1987 • 596 citations

Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.

1991 • 574 citations

A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

1989 • 566 citations

GPIIb-IIIa: The responsive integrin

1991 • 527 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

1985 • 517 citations

The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.

1987 • 512 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.

1990 • 486 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

1991 • 481 citations

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chain

1984 • 479 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes.

1990 • 462 citations

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.

1991 • 447 citations

Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface

1990 • 446 citations

The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.

1988 • 446 citations

An interaction between vinculin and talin

1984 • 442 citations

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion.

1986 • 442 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

1986 • 429 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Two contrary functions of tenascin: Dissection of the active sites by recombinant tenascin fragments

1989 • 415 citations

Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.

1990 • 408 citations

Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

1990 • 405 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

1991 • 401 citations

Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

1990 • 398 citations

The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.

1989 • 388 citations

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

1990 • 375 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

1991 • 357 citations

Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases.

1986 • 355 citations

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989 • 352 citations

Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.

1990 • 346 citations

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

1989 • 343 citations

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

1987 • 334 citations

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

1990 • 323 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

Modulation of the Affinity of Integrin α _IIb β ₃ (GPIIb-IIIa) by the Cytoplasmic Domain of α _IIb

1991 • 322 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

The Human Laminin Receptor Is a Member of the Integrin Family of Cell Adhesion Receptors

1988 • 310 citations

Cytoadhesins, Integrins, and Platelets

1988 • 306 citations

Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins.

1986 • 305 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

The integrin alpha 6 beta 4 is a laminin receptor.

1992 • 299 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

1992 • 292 citations

The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

1990 • 288 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

1992 • 285 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Transient adhesion of neutrophils to endothelium.

1989 • 279 citations

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.

1990 • 278 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Alpha 2 beta 1 integrins from different cell types show different binding specificities.

1990 • 274 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

The dermal-epidermal junction of human skin contains a novel laminin variant.

1992 • 268 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit

1991 • 262 citations

The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

1988 • 258 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

An interaction between zyxin and alpha-actinin.

1992 • 251 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

Aggregation of complement receptors on human neutrophils in the absence of ligand.

1987 • 250 citations

Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.

1990 • 249 citations

Presence of an SH2 Domain in the Actin-Binding Protein Tensin

1991 • 248 citations

An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.

1987 • 246 citations

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

1991 • 244 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.

1991 • 241 citations

A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.

1992 • 239 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

1990 • 238 citations

Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.

1990 • 238 citations

Identification of integrin collagen receptors on human melanoma cells

1989 • 237 citations

H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis [published erratum appears in J Cell Biol 1992 Jul;118(1):213]

1992 • 236 citations

The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

1988 • 235 citations

Identification of a new hemidesmosomal protein, HD1: a major, high molecular mass component of isolated hemidesmosomes.

1992 • 231 citations

Tenascin mediates cell attachment through an RGD-dependent receptor.

1989 • 231 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.

1989 • 230 citations

Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins.

1991 • 230 citations

Fibronectin receptor structures in the VLA family of heterodimers

1987 • 230 citations

A family of beta 7 integrins on human mucosal lymphocytes.

1992 • 227 citations

A function for the integrin alpha 6 beta 4 in the hemidesmosome.

1991 • 225 citations

Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs.

1987 • 223 citations

Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion.

1991 • 223 citations

Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide

1991 • 221 citations

The α6β1 (VLA-6) and α6β4 protein complexes: tissue distribution and biochemical properties

1990 • 219 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

A new surface antigen on intraepithelial lymphocytes in the intestine

1990 • 216 citations

Polarized integrin mediates human keratinocyte adhesion to basal lamina.

1990 • 216 citations

The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor.

1987 • 215 citations

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit.

1992 • 214 citations

Effects of Modifications of the RGD Sequence and Its Context on Recognition by the Fibronectin Receptor

1989 • 213 citations

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components.

1992 • 205 citations

A discrete sequence in a platelet integrin is involved in ligand recognition

1991 • 204 citations

Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands.

1989 • 204 citations

Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.

1991 • 197 citations

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

1990 • 195 citations

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen.

1990 • 191 citations

Cell-surface regulation of β1-integrin activity on developing retinal neurons

1991 • 191 citations

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

1991 • 189 citations

Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures.

1988 • 186 citations

Monoclonal antibody GB3, a new probe for the study of human basement membranes and hemidesmosomes

1987 • 185 citations

Molecular cloning of the human α6 integrin subunit

1991 • 183 citations

Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor .alpha.-subunits and platelet glycoprotein IIb

1987 • 183 citations

Expression of normal and mutant avian integrin subunits in rodent cells [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1187]

1989 • 181 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis

1991 • 180 citations

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.

1990 • 180 citations

Cloning and expression of a divergent integrin subunit beta 8.

1991 • 179 citations

Bullous Pemphigoid Antigen Localization Suggests an Intracellular Association with Hemidesmosomes

1985 • 178 citations

Subunit structure of a laminin-binding integrin and localization of its binding site on laminin

1989 • 172 citations

Cloning, primary structure and properties of a novel human integrin beta subunit.

1990 • 170 citations

Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins

1987 • 168 citations

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

1989 • 167 citations

Analysis of the tumor-associated antigen TSP-180

1989 • 166 citations

The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin.

1991 • 164 citations

Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

1992 • 163 citations

Cell adhesion, spreading and neurite stimulation by laminin fragment E8 depends on maintenance of secondary and tertiary structure in its rod and globular domain

1990 • 163 citations

A conformation-dependent epitope of human platelet glycoprotein IIIa

1990 • 162 citations

Antibody to integrin α6 subunit specifically inhibits cell-binding to laminin fragment 8

1990 • 161 citations

Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.

1991 • 161 citations

Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor.

1988 • 160 citations

Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation.

1991 • 160 citations

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.

1990 • 158 citations

Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin.

1991 • 158 citations

Identification of a neuronal laminin receptor: An Mr 200K/120K integrin heterodimer that binds laminin in a divalent cation-dependent manner

1988 • 153 citations

Isolation and characterization of a platelet surface collagen binding complex related to VLA-2

1988 • 152 citations

Identification of the Arg‐Gly‐Asp sequence in laminin A chain as a latent cell‐binding site being exposed in fragment P1

1990 • 150 citations

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit.

1993 • 145 citations

A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.

1992 • 144 citations

Production of Rabbit Antibodies Against Carboxy-Terminal Epitopes Encoded by Bullous Pemphigoid cDNA

1990 • 144 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1.

1992 • 141 citations

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.

1990 • 141 citations

Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3).

1988 • 140 citations

Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin.

1992 • 140 citations

Adhesion of T and B lymphocytes to extracellular matrix and endothelial cells can be regulated through the beta subunit of VLA

1992 • 139 citations

The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen.

1990 • 137 citations

Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets.

1988 • 137 citations

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment.

1988 • 135 citations

Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.

1991 • 135 citations

Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes.

1991 • 135 citations

A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the alpha 3 beta 1 integrin

1992 • 135 citations

Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17

1988 • 134 citations

Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.

1992 • 131 citations

The A9 Antigen Associated with Aggressive Human Squamous Carcinoma Is Structurally and Functionally Similar to the Newly Defined Integrin α6β4

1991 • 130 citations

Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins.

1990 • 127 citations

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

1991 • 124 citations

Developmentally regulated alternative splicing of Drosophila integrin PS2 α transcripts

1989 • 124 citations

Mouse heart laminin

1989 • 123 citations

An alternative cytoplasmic domain of the integrin beta 3 subunit.

1989 • 123 citations

Monoclonal antibodies against laminin A chain fragment E3 and their effects on binding to cells and proteoglycan and on kidney development

1992 • 122 citations

An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain.

1992 • 120 citations

The role of phosphorylation and limited proteolytic cleavage of talin and vinculin in the disruption of focal adhesion integrity

1989 • 120 citations

Human melanoma cells express a novel integrin receptor for laminin

1989 • 120 citations

Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.

1988 • 112 citations

Variants of the α₆β₁Laminin Receptor in Early Murine Development: Distribution, Molecular Cloning and Chromosomal Localization of the Mouse Integrin α₆Subunit

1993 • 108 citations

Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells

1991 • 108 citations

A human integrin β1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing

1990 • 106 citations

Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin.

1991 • 105 citations

The human intraepithelial lymphocyte marker HML‐1 is an integrin consisting of a β7 subunit associated with a distinctive α chain

1992 • 101 citations

Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II.

1989 • 95 citations

Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

1990 • 95 citations

Platelet glycoprotein IIb. Chromosomal localization and tissue expression.

1987 • 93 citations

Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic.

1988 • 88 citations

Nerve growth factor induces increased expression of a laminin-binding integrin in rat pheochromocytoma PC12 cells

1990 • 88 citations

Laminin-binding integrin α7β1 : functional characterization and expression in normal and malignant melanocytes

1991 • 86 citations

Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.

1988 • 85 citations

Somatic cell genetic analysis of human cell surface antigens: chromosomal assignments and regulation of expression in rodent-human hybrid cells.

1984 • 85 citations

Structure of laminin variants. The 300-kDa chains of murine and bovine heart laminin are related to the human placenta merosin heavy chain and replace the a chain in some laminin variants.

1991 • 84 citations

The high‐affinity binding of laminin to cells

1989 • 83 citations

Isolation of α6β1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment

1991 • 80 citations

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v.

1990 • 80 citations

Multiple cell surface receptors for the short arms of laminin: alpha 1 beta 1 integrin and RGD-dependent proteins mediate cell attachment only to domains III in murine tumor laminin.

1991 • 76 citations

Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro

1991 • 75 citations

Cloning and sequence analysis of a novel β₂related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains

1990 • 74 citations

Glycoprotein IIIa is phosphorylated in intact human platelets

1990 • 72 citations

Biochemical analysis of two cell surface glycoprotein complexes, very common antigen 1 and very common antigen 2. Relationship to very late activation T cell antigens.

1987 • 72 citations

Identification of a monoclonal antibody against platelet GPIIb that interacts with a calcium-binding site and induces aggregation.

1990 • 71 citations

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa.

1992 • 66 citations

Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs.

1990 • 60 citations

Role of type III homology repeats in cell adhesive function within the cell-binding domain of fibronectin.

1991 • 56 citations

Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily.

1990 • 55 citations

The integrin complex αvβ3 participates in the adhesion of microvascular endothelial cells to fibronectin

1991 • 55 citations

Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable.

1991 • 55 citations

Alternative proteolytic processing of platelet membrane glycoprotein IIb.

1988 • 54 citations

EA-1, a novel adhesion molecule involved in the homing of progenitor T lymphocytes to the thymus.

1991 • 54 citations

Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.

1990 • 53 citations

Cellular partitioning of beta-1 integrins and their phosphorylated forms is altered after transformation by Rous sarcoma virus or treatment with cytochalasin D.

1991 • 42 citations

The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester.

1990 • 41 citations

Molecular cloning of the mouse integrin beta 7 subunit.

1992 • 39 citations

Identity between the novel integrin β7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine

1991 • 37 citations

Differences in laminin fragment interactions of normal and transformed endothelial cells

1991 • 35 citations

Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants.

1984 • 31 citations

The gene for the alpha 4 subunit of the VLA-4 integrin maps to chromosome 2Q31-32

1991 • 19 citations

Mapping of the human VLA‐α4 gene to chromosome 2q31‐q32

1992 • 12 citations

Regional localization of the human vitronectin receptor α subunit gene (VNRA) to chromosome 2q31→q32

1993 • 8 citations

Deleted Work

1955 • 0 citations