Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.

Adhesion receptors of the immune system

1990 • 6,585 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Specific interaction of vinculin with α-actinin

1987 • 185 citations

Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway.

1990 • 185 citations

Integrin, A Transmembrane Glycoprotein Complex Mediating Cell-Substratum Adhesion

1987 • 176 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.

1990 • 163 citations

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.

1990 • 158 citations

Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.

1989 • 158 citations

Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.

1990 • 154 citations

Alloantigen Recognition Is Preceded by Nonspecific Adhesion of Cytotoxic T Cells and Target Cells

1986 • 145 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

The CD2 antigen associates with the T-cell antigen receptor CD3 antigen complex on the surface of human T lymphocytes

1989 • 127 citations

Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells.

1990 • 124 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

Cytoskeleton-associated cell contacts

1989 • 115 citations

Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes

1989 • 109 citations

The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells.

1985 • 106 citations

Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.

1990 • 89 citations

Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation.

1990 • 67 citations

CTL adhesion and antigen recognition are discrete steps in the human CTL-target cell interaction.

1987 • 52 citations

Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton.

1989 • 49 citations

T-cell receptor-negative natural killer cells display antigen-specific cytotoxicity for microvascular endothelial cells.

1990 • 32 citations

Ligand-induced association of surface immunoglobulin with the detergent insoluble cytoskeleton may involve alpha-actinin.

1988 • 25 citations

EVIDENCE THAT CYTOTOXIC LYMPHOCYTES ALTER AND TRAVERSE ALLOGENEIC ENDOTHELIAL CELL MONOLAYERS

1989 • 12 citations

The role of physical forces on cytotoxic T cell-target cell conjugate stability.

1990 • 11 citations