Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Arg-Gly-Asp: A versatile cell recognition signal

1986 • 1,413 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

Variants of the cell recognition site of fibronectin that retain attachment-promoting activity.

1984 • 685 citations

Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

1985 • 659 citations

Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

1987 • 653 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.

1984 • 465 citations

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule

1981 • 444 citations

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion.

1986 • 442 citations

Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin.

1980 • 441 citations

Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

1986 • 429 citations

Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.

1984 • 429 citations

Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin.

1985 • 418 citations

Fibronectin and wound healing

1984 • 379 citations

Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.

1987 • 350 citations

Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts.

1985 • 335 citations

Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin

1985 • 299 citations

The Dynamics of Proteins

1986 • 281 citations

Cell surface heparan sulfate mediates some adhesive responses to glycosaminoglycan-binding matrices, including fibronectin.

1983 • 281 citations

Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.

1987 • 255 citations

Interaction of fibronectin with its receptor on platelets

1985 • 251 citations

Synthetic peptide with cell attachment activity of fibronectin.

1983 • 248 citations

Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion.

1985 • 241 citations

The role of cell adhesion proteins?laminin and fibronectin?in the movement of malignant and metastatic cells

1985 • 236 citations

Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion.

1985 • 220 citations

Fibronectins

1986 • 209 citations

Complete primary structure of bovine plasma fibronectin

1986 • 193 citations

Cell Migration in the Vertebrate Embryo: Role of Cell Adhesion and Tissue Environment in Pattern Formation

1985 • 174 citations

The interaction of fibronectin fragments with fibroblastic cells.

1985 • 168 citations

Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets

1987 • 165 citations

Synthetic peptides competitively inhibit both direct binding to fibroblasts and functional biological assays for the purified cell-binding domain of fibronectin.

1985 • 148 citations

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment.

1988 • 135 citations

Fibronectin Domains and Receptors

1989 • 118 citations

Peptide inhibitors of fibronectin, laminin, and other adhesion molecules: Unique and shared features

1987 • 114 citations

Substratum contacts and cytoskeletal reorganization of BALB/c 3T3 cells on a cell-binding fragment and heparin-binding fragments of plasma fibronectin

1986 • 111 citations

Amino acid sequence specificities of an adhesive recognition signal

1985 • 106 citations

The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.

1987 • 96 citations

Fibroblast adhesion to RGDS shows novel features compared with fibronectin.

1987 • 85 citations

Collagen can modulate cell interactions with fibronectin.

1985 • 63 citations

Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast.

1986 • 52 citations

Variants of the cell recognition site of fibronectin that retain attachment-promoting activity

1985 • 46 citations

Expression of the cell-binding domain of human fibronectin in E. coli

1987 • 34 citations

Effects of fibronectin-related peptides on cell spreading

1985 • 29 citations