Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Fluorescence Energy Transfer as a Spectroscopic Ruler

1978 • 2,370 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 841 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

1985 • 593 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Direct detection of activated platelets and platelet-derived microparticles in humans

1990 • 429 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1990 • 328 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen

1989 • 213 citations

Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis

1984 • 203 citations

Resting platelets contain a substantial centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some but not other extracellular proteins.

1986 • 191 citations

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

1987 • 186 citations

Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.

1983 • 185 citations

Calcium regulation of the platelet membrane glycoprotein IIb-IIIa complex.

1985 • 178 citations

Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses.

1986 • 164 citations

Efficient surface expression of platelet GPIIb-IIIa requires both subunits

1989 • 158 citations

Calcium cation regulation of glycoprotein IIb-IIIa complex formation in platelet plasma membranes.

1983 • 144 citations

Redistribution of the fibrinogen receptor of human platelets after surface activation.

1984 • 133 citations

Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.

1987 • 133 citations

Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex.

1988 • 133 citations

Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady‐state fluorimetric and flow cytometric methods

1984 • 132 citations

Activation of human platelets by ADP causes a rapid rise in cytosolic free calcium without hydrolysis of phosphatidylinositol-4,5-bisphosphate

1985 • 109 citations

Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex.

1985 • 105 citations

Temperature-dependent effects of EDTA on the membrane glycoprotein IIb- IIIa complex and platelet aggregability

1986 • 100 citations

Activation affects access to the platelet receptor for adhesive glycoproteins.

1986 • 93 citations

Fibronectin-binding properties of the purified platelet glycoprotein IIb-IIIa complex.

1986 • 93 citations

Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.

1984 • 85 citations

Physical association between MHC class I and class II molecules detected on the cell surface by flow cytometric energy transfer.

1989 • 79 citations

Changes in surface-bound and exchangeable calcium during platelet activation.

1982 • 77 citations

Biochemical and functional consequences of dissociation of the platelet membrane glycoprotein IIb-IIIa complex

1985 • 74 citations

Glycoprotein IIIa is phosphorylated in intact human platelets

1990 • 72 citations

Flow cytometric measurements of fluorescence energy transfer using single laser excitation

1987 • 66 citations

Platelet membrane glycoprotein IIb-IIIa complex incorporated into phospholipid vesicles. Preparation and morphology.

1985 • 60 citations

Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine

1986 • 59 citations

The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa

1987 • 58 citations

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

1988 • 51 citations

Proximity measurements of cell surface proteins by fluorescence energy transfer

1987 • 32 citations

CALCIUM REGULATION OF GLYCOPROTEINS IIb AND IIIa IN HUMAN PLATELET MEMBRANESa

1983 • 9 citations