A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 841 citations

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

1991 • 481 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Molecular Defects in Interactions of Platelets with the Vessel Wall

1984 • 381 citations

Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation.

1980 • 373 citations

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1990 • 328 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

Cytoadhesins, Integrins, and Platelets

1988 • 306 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies.

1983 • 241 citations

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.

1987 • 222 citations

Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide

1991 • 221 citations

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen

1989 • 213 citations

The genomic organization of platelet glycoprotein IIIa.

1990 • 205 citations

A discrete sequence in a platelet integrin is involved in ligand recognition

1991 • 204 citations

Guide to molecular cloning techniques

1988 • 198 citations

Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.

1986 • 161 citations

Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies

1990 • 158 citations

Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.

1984 • 148 citations

Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen γ chain

1982 • 141 citations

The mechanism of thrombin-induced platelet factor 4 secretion

1980 • 104 citations

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function.

1987 • 74 citations

Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine

1986 • 59 citations

A Variant of Glanzmann's Thrombasthenia Characterized by Abnormal Glycoprotein IIb/IIIa Complex Formation

1989 • 35 citations

Expression of intracellular fibrinogen on the surface of stimulated platelets

1986 • 32 citations

Mechanisms for Expression of Thrombospondin on the Platelet Cell Surface

1987 • 24 citations