Glycoprotein IIIa is phosphorylated in intact human platelets

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Exposure of platelet fibrinogen receptors by ADP and epinephrine.

1979 • 868 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity

1975 • 413 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombin

1980 • 299 citations

Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody.

1983 • 280 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.

1989 • 260 citations

Role of phosphorylation in mediating the association of myosin with the cytoskeletal structures of human platelets.

1982 • 195 citations

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

1987 • 186 citations

Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes

1975 • 155 citations

Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets

1977 • 144 citations

In situ Phosphorylation of Platelet Actin-binding Protein by cAMP-dependent Protein Kinase Stabilizes It against Proteolysis by Calpain

1989 • 138 citations

A method for purifying the platelet membrane glycoprotein IIb-IIIa complex

1985 • 121 citations

Inhibition of Protein Kinase C by Staurosporine Promotes Elevated Accumulations of Inositol Trisphosphates and Tetrakisphosphate in Human Platelets Exposed to Thrombin

1989 • 113 citations

Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP.

1980 • 107 citations

Distinct structural requirements of Ca²⁺/phospholipid‐dependent protein kinase (protein kinase C) and cAMP‐dependent protein kinase as evidenced by synthetic peptide substrates

1985 • 103 citations

Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein.

1985 • 96 citations

Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter

1984 • 84 citations

Subcellular distribution of the different platelet proteins phosphorylated on exposure of intact platelets to ionophore A23187 or to prostaglandin E1. Possible role of a membrane phosphopolypeptide in the regulation of calcium-ion transport

1979 • 83 citations

Platelet glycoprotein Ibβ is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase

1989 • 81 citations

A variant of Glanzmann's thrombasthenia with abnormal glycoprotein IIb-IIIa complexes in the platelet membrane.

1987 • 75 citations

Interaction of fibrinogen with its platelet receptor: kinetics and effect of pH and temperature

1981 • 69 citations

Platelet glycoproteins IIb and IIIa as a calcium channel in liposomes

1988 • 44 citations

Nonmuscle myosin phosphorylation sites for calcium-dependent and calcium-independent protein kinases

1986 • 13 citations