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Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

1997 • 828 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 • 585 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1996 • 576 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Aminoguanidine selectively inhibits inducible nitric oxide synthase

1993 • 412 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Alterations in nitric oxide production in various forms of circulatory shock.

1995 • 321 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock

1994 • 224 citations

The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

1995 • 219 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

Aminoguanidine Is an Isoform-Selective, Mechanism-Based Inactivator of Nitric Oxide Synthase

1995 • 191 citations

Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta

1994 • 143 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

1983 • 131 citations

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation

1993 • 130 citations

Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis

1996 • 117 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase

1995 • 112 citations

Attenuation of endotoxin‐induced multiple organ dysfunction by 1‐amino‐2‐hydroxy‐guanidine, a potent inhibitor of inducible nitric oxide synthase

1996 • 110 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

The influence of catabolic reactions on polyamine excretion

1985 • 110 citations

Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia

1994 • 106 citations

Inhibition of Nitric Oxide With Aminoguanidine Reduces Bacterial Translocation After Endotoxin Challenge In Vivo

1996 • 101 citations

Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia

1996 • 86 citations

Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform

1996 • 81 citations

Prevention of the Expression of Inducible Nitric Oxide Synthase by Aminoguanidine or Aminoethyl-Isothiourea in Macrophages and in the Rat

1996 • 80 citations

Intrarenal haemodynamics and renal dysfunction in endotoxaemia: effects of nitric oxide synthase inhibition

1997 • 77 citations

Comparison of the effects of aminoguanidine and Nω-nitro-l-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat

1996 • 74 citations

Nitric Oxide Mediates Hepatic Cytochrome P450 Dysfunction Induced by Endotoxin

1996 • 59 citations

Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform

1995 • 44 citations

NITRIC OXIDE SYNTHASE INHIBITION DOES NOT PREVENT CARDIAC DEPRESSION IN ENDOTOXIC SHOCK

1995 • 43 citations

Alteration by lipopolysaccharide of the relationship between intracellular calcium levels and contraction in rat mesenteric artery

1996 • 42 citations

AMINOETHYL-ISOTHIOUREA, A SELECTIVE INHIBITOR OF INDUCIBLE NITRIC OXIDE SYNTHASE ACTIVITY, IMPROVES LIVER CIRCULATION AND OXYGEN METABOLISM IN A PORCINE MODEL OF ENDOTOXEMIA

1998 • 33 citations

Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock

1996 • 22 citations

Excessive NO production dose not account for the inhibition of hepatic gluconeogenesis in endotoxemia

1996 • 16 citations

Effect of a Nitric Oxide Synthase Inhibitor, S-Ethylisothiourea, on Cultured Cells and Cardiovascular Functions of Normal and Lipopolysaccharide-Treated Rabbits

1996 • 15 citations

Effect of S-Ethylisothiourea, a Putative Inhibitor of Inducible Nitric Oxide Synthase, on Mouse Skin Vascular Permeability

1996 • 7 citations

Plasma Nitrate and Pteridine Levels in Experimental Bacteremia in Baboons

1995 • 5 citations