Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

The Adult Respiratory Distress Syndrome

1971 • 774 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

1995 • 491 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Alterations in nitric oxide production in various forms of circulatory shock.

1995 • 321 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia

1994 • 250 citations

Pulmonary Pathology of the Adult Respiratory Distress Syndrome

1990 • 247 citations

Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo

1995 • 235 citations

Pathophysiology of Shock, Sepsis, and Organ Failure

1993 • 216 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

Evidence for in vivo peroxynitrite production in human acute lung injury.

1995 • 193 citations

Aminoguanidine Is an Isoform-Selective, Mechanism-Based Inactivator of Nitric Oxide Synthase

1995 • 191 citations

INVITED OPINION

1994 • 185 citations

Plasma nitric oxide levels in newborn infants with sepsis

1993 • 133 citations

Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome

1995 • 132 citations

Sepsis Syndrome, the Adult Respiratory Distress Syndrome, and Nosocomial Pneumonia

1990 • 121 citations

Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers

1995 • 110 citations

Mechanisms and Mediators of the Adult Respiratory Distress Syndrome

1990 • 106 citations

Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators

1995 • 95 citations

Corticosteroid Inhibition of Airway Microvascular Leakage

1991 • 95 citations

Neurogenic plasma extravasation: inhibition by morphine in guinea pig airways in vivo

1989 • 82 citations

Molecular Basis of Pulmonary Oxygen Toxicity

1987 • 81 citations

Neutrophil alveolitis following endotoxemia. Enhancement by previous exposure to hyperoxia.

1984 • 67 citations

Nitric oxide-related oxidants in acute lung injury.

1995 • 67 citations

Nitric oxide synthase activity, viability and cyclic GMP levels in rat colonic epithelial cells: effect of endotoxin challenge.

1994 • 62 citations

Free radical-mediated diseases in pediatrics.

1992 • 57 citations

The Adult Respiratory Distress Syndrome

1990 • 55 citations

Intestinal reperfusion up-regulates inducible nitric oxide synthase activity within the lung

1995 • 55 citations

Actions and interactions of mediator systems and mediators in the pathogenesis of ARDS and multiorgan failure

1991 • 50 citations

Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats

1993 • 37 citations

Inhaled nitric oxide in acute lung disease.

1995 • 36 citations

Adult Respiratory Distress Syndrome in Children

1994 • 29 citations

Neutrophil Alveolitis following Endotoxemia

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Pulmonary dysfunction caused by diffuse lung inflammation. Roles of metabolites of arachidonic acid.

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Models of Endotoxemia in Rodents

1993 • 6 citations