Dissecting Molecular Carcinogenesis: Development Of Transgenic Mouse Models By Epidermal Gene Targeting

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

ras GENES

1987 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Gain of function mutations in p53

1993 • 876 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetic Toxicity Assays

1987 • 818 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Cooperation between oncogenes

1991 • 792 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Tumor suppressor genes

1991 • 775 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Transforming growth factor α

1988 • 707 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Heterogeneity of the human papillomavirus group

1989 • 677 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Multistage carcinogenesis in mouse skin

1992 • 647 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Human gene therapy

1992 • 559 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers.

1989 • 522 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The Emerging Epidemic of Melanoma and Squamous Cell Skin Cancer

1989 • 468 citations

How many mutations are required for tumorigenesis? implications from human cancer data

1993 • 466 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Oncogene Activation in Chemical Carcinogenesis

1988 • 383 citations

Specific interaction between HPV-16 E1–E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network

1991 • 327 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.

1990 • 300 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Ras gene mutation and amplification in human nonmelanoma skin cancers

1991 • 276 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

1990 • 270 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

HUMAN GENE THERAPY

1993 • 262 citations

v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

1986 • 244 citations

Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.

1993 • 243 citations

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis.

1993 • 237 citations

Fos-IacZ transgenic mice: Mapping sites of gene induction in the central nervous system

1992 • 237 citations

Expression of p53 in premalignant and malignant squamous epithelium.

1991 • 237 citations

The Keratinocyte handbook

1994 • 229 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1989 • 227 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

1991 • 216 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene

1986 • 206 citations

The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes.

1989 • 194 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

The Oncogene Handbook

1988 • 181 citations

Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein

1982 • 181 citations

c-fos expression induces bone tumors in transgenic mice.

1989 • 177 citations

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.

1991 • 170 citations

Inducible binding of a factor to the c-fos regulatory region.

1987 • 168 citations

Papillomaviruses in human cancers

1988 • 164 citations

Progressing toward a molecular description of colorectal cancer development

1992 • 148 citations

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

1991 • 139 citations

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.

1993 • 135 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Induction of papillomas with a high probability of conversion to malignancy

1985 • 132 citations

Induction of Transforming Growth Factor-α Expression in Human Keratinocytes by Phorbol Esters

1989 • 131 citations

Enhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells.

1993 • 131 citations

c-myc and c-fos expression in differentiating mouse primary keratinocytes.

1986 • 130 citations

Chemically induced skin carcinogenesis in a transgenic mouse line (TG·AC) carrying a v-Ha-ras gene

1993 • 129 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

1983 • 124 citations

Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas

1991 • 124 citations

Microinjection of Transforming ras protein induces c-fos Expression

1987 • 123 citations

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

1993 • 123 citations

Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors.

1992 • 121 citations

Bovine papillomavirus genome elicits skin tumours in transgenic mice

1986 • 121 citations

Tumor-suppressor p53 and the cell cycle

1993 • 120 citations

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

1991 • 117 citations

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

1991 • 116 citations

Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses

1985 • 112 citations

Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice

1990 • 109 citations

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.

1992 • 107 citations

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

1993 • 104 citations

OZONE DEPLETION AND INCREASE IN ANNUAL CARCINOGENIC ULTRAVIOLET DOSE

1990 • 103 citations

Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein.

1988 • 101 citations

Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.

1988 • 100 citations

Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.

1993 • 99 citations

Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia

1988 • 98 citations

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.

1990 • 98 citations

Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation?

1989 • 96 citations

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions

1989 • 96 citations

Demonstration in living cells of an intragenic negative regulatory element within the rodent c-fos gene

1990 • 96 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

FBR murine osteosarcoma virus I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product

1984 • 90 citations

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

1990 • 87 citations

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor‐inducing effect of wounding in initiated nmri mouse skin

1989 • 83 citations

Microinjection of transforming ras protein induces c-fos expression.

1987 • 78 citations

Evidence for autocrine/paracrine growth stimulation by transforming growth factor‐α during the process of skin tumor promotion

1991 • 72 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression

1988 • 70 citations

Differences in transformation activity between HPV-18 and HPV-16 map to the viral LCR-E6-E7 region

1991 • 66 citations

Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.

1993 • 63 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Presence of Human Papilloma Virus Type 16 DNA Sequences in Human Nonmelanoma Skin Cancers

1991 • 56 citations

TGF-α Is Widely Expressed in Differentiated as well as Hyperproliferative Skin Epithelium

1991 • 56 citations

Mutant p53 expression in solar keratosis: an immunohistochemical study

1992 • 56 citations

Very high incidence of germ cell tumorigenesis (seminomagenesis) in human papillomavirus type 16 transgenic mice

1991 • 55 citations

Epidermal expression of transforming growth factor‐α in transgenic mice: Induction of spontaneous and 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced papillomas via a mechanism independent of Ha‐ras activation or overexpression

1994 • 53 citations

Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells.

1993 • 53 citations

Epidermal growth factor and transforming growth factor ? induce c-fos gene expression in retinal muller cells in vivo

1991 • 51 citations

Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.

1993 • 49 citations

Transfection of the EJ ras^Ha Gene into Keratinocytes Derived from Carcinogen-Induced Mouse Papillomas Causes Malignant Progression

1986 • 47 citations

Allelotype analysis of mouse skin tumors using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7, and 11.

1993 • 45 citations

Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo

1989 • 45 citations

Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo

1988 • 43 citations

Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression.

1986 • 41 citations

High Levels of c-fos Proto-Oncogene Expression in Normal Human Adult Skin

1990 • 40 citations

Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis.

1991 • 39 citations

Genetic toxicology: current status of methods of carcinogen identification.

1993 • 39 citations

Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion.

1993 • 35 citations

Direct growth stimulation of normal human epithelial cells by mutant p53

1993 • 29 citations

Inhibition of chemical carcinogenesis in vivo by azatyrosine.

1992 • 26 citations

Inhibition of tumor formation from grafted murine papilloma cells by treatment of grafts with staurosporine, an inducer of squamous differentiation

1993 • 26 citations

Transforming growth factor alpha (TGFα) induction of c-fos and c-myc expression in C3H 10Tl/2 cells

1988 • 25 citations

Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity

1985 • 24 citations

Comparative analysis of cellular and tissular expression of c-fos in human keratinocytes: evidence of its role in cell differentiation.

1994 • 24 citations

Abnormalities of epidermal differentiation associated with expression of the human papillomavirus type 1 early region in transgenic mice

1992 • 22 citations

Ozone depletion and skin cancer

1988 • 18 citations

Different levels of v‐Ha‐ras p21 expression in primary keratinocytes transformed with harvey sarcoma virus correlate with benign versus malignant behavior

1993 • 15 citations

Unregulated and basal transcriptional activities of the regulatory sequence of the type 18 human papillomavirus genome in transgenic mice

1992 • 11 citations