Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

ras GENES

1987 • 3,818 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

MOLECULAR AND CELLULAR BIOLOGY OF INTERMEDIATE FILAMENTS

1988 • 1,395 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Tumor suppressor genes

1991 • 775 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes.

1984 • 567 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression

1987 • 344 citations

The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins

1983 • 326 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Neoplastic Development

1970 • 295 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

1990 • 270 citations

v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

1986 • 244 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins

1987 • 187 citations

Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies.

1984 • 186 citations

Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis.

1988 • 182 citations

Structure of a gene for the human epidermal 67-kDa keratin.

1985 • 160 citations

Differences of expression of cytokeratin polypeptides in various epithelial skin tumors

1984 • 145 citations

Identifying Tumor Suppressor Genes in Human Colorectal Cancer

1990 • 143 citations

Cocarcinogenesis and biological effects of tumor promoters.

1982 • 133 citations

Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

1983 • 124 citations

Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses

1985 • 112 citations

Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium.

1990 • 106 citations

Aberrant expression during two‐stage mouse skin carcinogenesis of a type 147‐kDa keratin, k13, normally associated with terminal differentiation of internal stratified epithelia

1988 • 98 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.

1990 • 87 citations

Keratins as markers of malignancy in mouse epidermal tumors

1980 • 86 citations

H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.

1988 • 75 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Detection and identification of activated oncogenes in human skin cancers occurring on sun-exposed body sites.

1988 • 64 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Early expression of type I K13 keratin in the progression of mouse skin papillomas

1990 • 58 citations

Keratin modifications in epidermis, papillomas, and carcinomas during two-stage carcinogenesis in the SENCAR mouse.

1982 • 55 citations

Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas.

1988 • 53 citations

A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.

1991 • 52 citations

Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors

1991 • 50 citations

Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo

1989 • 45 citations

Proto-oncogene expression during two-stage carcinogenesis in mouse skin

1985 • 35 citations

Abnormal expression and processing of keratins in pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice.

1987 • 30 citations

Epidermal tumor promotion by regeneration.

1982 • 19 citations

Transfection of activated Ha-ras protooncogenes causes mouse mammary hyperplasia.

1990 • 15 citations

Lower prevalence of chromosome aberrations and SCEs in self-poisoned pregnant women

1988 • 9 citations