HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences

1981 • 657 citations

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

1985 • 600 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

1986 • 440 citations

Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.

1987 • 417 citations

Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome

1987 • 341 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.

1988 • 284 citations

Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix

1985 • 271 citations

Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms

1989 • 264 citations

Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

1988 • 259 citations

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

1989 • 247 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

1987 • 230 citations

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1989 • 227 citations

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

1987 • 203 citations

Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA.

1988 • 200 citations

Identification of a second transforming region in bovine papillomavirus DNA.

1984 • 197 citations

Characterization of primary human keratinocytes transformed by human papillomavirus type 18

1988 • 192 citations

Human Papillomaviruses And Genital Cancer

1987 • 186 citations

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1989 • 178 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

Definition of precursors

1981 • 170 citations

Human papillomaviruses and cancer

1986 • 154 citations

Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA

1988 • 147 citations

Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells.

1989 • 145 citations

Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells

1988 • 143 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

1988 • 118 citations

Cloning of monomeric human papillomavirus type 16 DNA integrated within cell DNA from a cervical carcinoma

1986 • 118 citations

Genital warts and cervical cancer III. Subclinical papillomaviral infection and cervical neoplasia are linked by a spectrum of continuous morphologic and biologic change

1984 • 106 citations

Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18

1988 • 94 citations

Functional dissociation of transforming genes of human papillomavirus type 16

1988 • 91 citations

Identification of a transforming gene of human papillomavirus type 16

1989 • 72 citations

Human papillomavirus type 16 E7 protein expressed in Escherichia coli and monkey COS-1 Cells: Immunofluorescence detection of the nuclear E7 protein

1989 • 65 citations

Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector

1989 • 63 citations

Functional similarity between HPV16E7, SV40 large T and adenovirus E1a proteins.

1989 • 56 citations

Expression of human papillomavirus type 16 E7 gene induces DNA synthesis of rat 3Y1 cells

1989 • 39 citations

Progress in Clinical Pathology

1976 • 33 citations

Successive steps in the process of immortalization identified by transfer of separate bovine papillomavirus genes into rat fibroblasts.

1989 • 19 citations