The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Human papillomavirus type 16 DNA sequence

1985 • 718 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

1985 • 600 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours

1985 • 480 citations

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

1986 • 440 citations

Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.

1987 • 417 citations

Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product

1985 • 402 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.

1987 • 327 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator

1987 • 278 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms

1989 • 264 citations

Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

1988 • 259 citations

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

1989 • 247 citations

Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA.

1988 • 200 citations

Characterization of primary human keratinocytes transformed by human papillomavirus type 18

1988 • 192 citations

Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization

1987 • 184 citations

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1989 • 178 citations

Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product

1987 • 173 citations

Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells

1989 • 171 citations

The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene.

1988 • 130 citations

Cloning of monomeric human papillomavirus type 16 DNA integrated within cell DNA from a cervical carcinoma

1986 • 118 citations

Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter

1988 • 112 citations

Molecular cloning and characterization of mutant and wild-type human beta-actin genes.

1984 • 108 citations

Regulation of human papillomavirus type 11 enhancer and E6 promoter by activating and repressing proteins from the E2 open reading frame: functional and biochemical studies

1988 • 93 citations

Functional dissociation of transforming genes of human papillomavirus type 16

1988 • 91 citations

Identification of a transforming gene of human papillomavirus type 16

1989 • 72 citations

Transformation of rat 3Y1 cells by human papillomavirus type‐18 DNA

1988 • 56 citations

Molecular Cloning and Characterization of Mutant and Wild-Type Human β-Actin Genes

1984 • 36 citations