Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Biochemical, physiological and medical aspects of ubiquinone function

1995 • 1,210 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

1997 • 739 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

1999 • 664 citations

Mitochondrial dysfunction in neurodegenerative diseases

1998 • 606 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1998 • 494 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Age‐related changes in the lipid compositions of rat and human tissues

1989 • 415 citations

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

1998 • 381 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Physiological roles of nicotinamide nucleotide transhydrogenase

1988 • 348 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

1987 • 332 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

1998 • 321 citations

Coenzyme Q₁₀ levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

1997 • 321 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.

1980 • 288 citations

Transport of calcium by mitochondria

1994 • 276 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

1998 • 255 citations

Lipid Compositions of Different Regions of the Human Brain During Aging

1990 • 250 citations

A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

1998 • 246 citations

The role of creatine kinase in inhibition of mitochondrial permeability transition

1997 • 240 citations

Peptidylproline cis/trans isomerases

1995 • 235 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1993 • 213 citations

Slow active/inactive transition of the mitochondrial NADH-ubiquinone reductase

1990 • 212 citations

Mitochondrial dysfunction in neurodegenerative disorders

1998 • 211 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

Mitochondrial channel activity studied by patch-clamping mitoplasts

1989 • 206 citations

Catalytic properties of the mitochondrial NADH–ubiquinone oxidoreductase (Complex I) and the pseudo-reversible active/inactive enzyme transition

1998 • 200 citations

Coenzyme Q₁₀ and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

1994 • 192 citations

The mitochondrial respiratory chain of yeast. Structure and biosynthesis and the role in cellular metabolism

1987 • 192 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

Intramitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmaleimide on mitochondrial function.

1979 • 189 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 172 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 166 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

Properties of a Cyclosporin-insensitive Permeability Transition Pore in Yeast Mitochondria

1997 • 132 citations

The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage

1972 • 106 citations

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

1996 • 105 citations

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

1992 • 98 citations

The mitochondrial permeability transition. Interactions of spermine, ADP, and inorganic phosphate.

1994 • 93 citations

Demonstration of the relation between the adenine nucleotide carrier and the structural changes of mitochondria as induced by adenosine 5'-diphosphate

1974 • 92 citations

Major changes in complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:coenzyme Q reductase

1995 • 88 citations

Induction of the mitochondrial permeability transition by N-ethylmaleimide depends on secondary oxidation of critical thiol groups. Potentiation by copper-ortho-phenanthroline without dimerization of the adenine nucleotide translocase

1998 • 87 citations

The specificity of mitochondrial complex I for ubiquinones

1996 • 87 citations

Selective inhibition of the mitochondrial permeability transition pore at the oxidation‐reduction sensitive dithiol by monobromobimane

1995 • 85 citations

Relations between extramitochondrial and intramitochondrial adenine nucleotide systems

1981 • 78 citations

Immunochemical characterization of the adenine nucleotide translocator

1984 • 77 citations

Proton Selective Substate of the Mitochondrial Permeability Transition Pore: Regulation by the Redox State of the Electron Transport Chain

1998 • 76 citations

Kinetics, control, and mechanism of ubiquinone reduction by the mammalian respiratory chain-linked NADH-ubiquinone reductase

1993 • 76 citations

cDNA cloning of rat mitochondrial cyclophilin

1997 • 73 citations

Activation of site I redox-driven H+ pump by exogenous quinones in intact mitochondria.

1982 • 69 citations

Effect of Ca2+ ions on the slow active/inactive transition of the mitochondrial NADH-ubiquinone reductase

1992 • 65 citations

Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

1998 • 65 citations

Ubiquinone, dolichol, and cholesterol metabolism in aging and Alzheimer's disease

1992 • 60 citations

Inhibition by spermine of the inner membrane permeability transition of isolated rat heart mitochondria

1992 • 59 citations

Localization of the Bcl-2 Protein to the Outer Mitochondrial Membrane by Electron Microscopy

1995 • 53 citations

Factors that influence phosphoenolpyruvate-induced calcium efflux from rat liver mitochondria

1974 • 52 citations

Chemical Modification of Arginines by 2,3-Butanedione and Phenylglyoxal Causes Closure of the Mitochondrial Permeability Transition Pore

1998 • 51 citations

Effect of Polycation Peptides on Mitochondrial Permeability Transition

1995 • 36 citations

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment

1996 • 35 citations

On the nature of P_i‐induced, Mg²⁺‐prevented Ca²⁺ release in rat liver mitochondria

1982 • 32 citations

Ubiquinone‐10 Protects Neurons from Virus‐Induced Degeneration

1994 • 26 citations

Inhibition of the mitochondrial cyclosporin A‐sensitive permeability transition pore by the arginine reagent phenylglyoxal

1997 • 26 citations

Improvement of cardiac function and myocardial energy metabolism of rats with chronic heart failure by long-term coenzyme Q10 treatment.

1994 • 25 citations

Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10

1994 • 23 citations

Possible mechanism by which coenzyme Q10 improves reoxygenation-induced recovery of cardiac contractile force after hypoxia.

1987 • 21 citations

Rapid efflux of Ca2+ from heart mitochondria in the presence of inorganic pyrophosphate

1984 • 14 citations

Coenzyme Q10 and colorectal neoplasms in aged patients.

1997 • 11 citations