Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10

Brain Metabolism during Fasting*

1967 • 1,590 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

1990 • 312 citations

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1985 • 290 citations

Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats

1974 • 237 citations

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

1992 • 167 citations

Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone

1989 • 160 citations

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

1991 • 117 citations

Lateral diffusion of ubiquinone during electron transfer in phospholipid- and ubiquinone-enriched mitochondrial membranes.

1982 • 107 citations

Therapy of mitochondrial disorders

1987 • 104 citations

Long‐term coenzyme Q ₁₀ therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency

1989 • 101 citations

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

1992 • 98 citations

Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

1991 • 76 citations

A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart

1981 • 74 citations

Protective Action of 1,3-Butanediol in Cerebral Ischemia. A Neurologic, Histologic, and Metabolic Study

1987 • 34 citations

Reduction of neurologic deficit by 1,3-butanediol induced ketosis in levine rats.

1985 • 29 citations

Butanediol induced cerebral protection from ischemic-hypoxia in the instrumented Levine rat.

1984 • 28 citations

Beneficial effect of 1,3-butanediol on cerebral energy metabolism and edema following brain embolization in rats.

1990 • 25 citations