How Cells Handle Cholesterol

Functional rafts in cell membranes

1997 • 9,471 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1999 • 1,708 citations

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1999 • 1,527 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1999 • 1,441 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1997 • 797 citations

Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts

2000 • 768 citations

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1999 • 628 citations

Membrane microdomains and caveolae

1999 • 580 citations

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

1999 • 562 citations

Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

2000 • 550 citations

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

2000 • 529 citations

The differential miscibility of lipids as the basis for the formation of functional membrane rafts

1998 • 512 citations

Structure and lipid transport mechanism of a StAR-related domain.

2000 • 509 citations

Cell cholesterol efflux: integration of old and new observations provides new insights

1999 • 502 citations

A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane

1996 • 496 citations

Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice

2000 • 477 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

Influenza Viruses Select Ordered Lipid Domains during Budding from the Plasma Membrane

1999 • 445 citations

Intracellular cholesterol transport

1999 • 416 citations

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

1999 • 375 citations

Post-Golgi biosynthetic trafficking

1997 • 373 citations

Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin

1996 • 366 citations

Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids.

1991 • 336 citations

Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes

2000 • 332 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Characterization of a Cytosolic Heat-shock Protein-Caveolin Chaperone Complex

1998 • 306 citations

Intracellular cholesterol transport

1997 • 295 citations

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding.

1992 • 295 citations

Topological Analysis of Niemann-Pick C1 Protein Reveals That the Membrane Orientation of the Putative Sterol-sensing Domain Is Identical to Those of 3-Hydroxy-3-methylglutaryl-CoA Reductase and Sterol Regulatory Element Binding Protein Cleavage-activating Protein

2000 • 291 citations

Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases

1999 • 288 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

2000 • 252 citations

Niemann–Pick C1 Is a Late Endosome-Resident Protein That Transiently Associates with Lysosomes and the Trans-Golgi Network

1999 • 252 citations

Role of Membrane Organization and Membrane Domains in Endocytic Lipid Trafficking

2000 • 245 citations

Jamming the endosomal system: lipid rafts and lysosomal storage diseases

2000 • 245 citations

Evidence That Phosphatidylserine Is Imported into Mitochondria via a Mitochondria-associated Membrane and That the Majority of Mitochondrial Phosphatidylethanolamine Is Derived from Decarboxylation of Phosphatidylserine

1995 • 244 citations

Major histocompatibility complex class I molecules mediate association of SV40 with caveolae.

1997 • 242 citations

Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol

1999 • 240 citations

Membrane rafts and signaling by the multichain immune recognition receptors

2000 • 226 citations

The assembly and secretion of apolipoprotein B-containing lipoproteins

1999 • 206 citations

The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism

2000 • 203 citations

Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles

2000 • 182 citations

Role of Niemann-Pick Type C1 Protein in Intracellular Trafficking of Low Density Lipoprotein-derived Cholesterol

2000 • 179 citations

Sterol Carrier Protein-2 Is Involved in Cholesterol Transfer from the Endoplasmic Reticulum to the Plasma Membrane in Human Fibroblasts

1995 • 167 citations

Intramitochondrial cholesterol transfer

2000 • 166 citations

Topology of glycosphingolipid degradation

1996 • 162 citations

Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane

1998 • 160 citations

Niemann–Pick Type C Mutations Cause Lipid Traffic Jam

2000 • 159 citations

Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells

1998 • 159 citations

Lysosomal Degradation on Vesicular Membrane Surfaces

1998 • 146 citations

Sterol carrier protein-2

2000 • 143 citations

Mutations in the Leucine Zipper Motif and Sterol-sensing Domain Inactivate the Niemann-Pick C1 Glycoprotein

1999 • 132 citations

Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin

2000 • 127 citations

The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol

1994 • 121 citations

Intracellular cholesterol trafficking: role of the NPC1 protein

2000 • 116 citations

Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

1999 • 110 citations

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1

1997 • 106 citations

Transbilayer movement of cholesterol in the human erythrocyte membrane.

1988 • 103 citations

A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis

2000 • 100 citations

A model for Niemann–Pick type C disease in the nematode Caenorhabditis elegans

2000 • 98 citations

Differential Effects of Sphingomyelin Hydrolysis and Cholesterol Transport on Oxysterol-binding Protein Phosphorylation and Golgi Localization

1998 • 90 citations

Phase topology and percolation in multi-phase lipid bilayers: is the biological membrane a domain mosaic?

1993 • 73 citations

Enrichment and localization of ganglioside GD3 and caveolin-1 in shed tumor cell membrane vesicles

2000 • 70 citations

Hepatocellular transport and secretion of biliary lipids

1999 • 57 citations

Family of human oxysterol binding protein (OSBP) homologues: a novel member implicated in brain sterol metabolism

1999 • 54 citations

Molecular aspects of intracellular sterol esterification: the acyl coenzyme A: cholesterol acyltransferase reaction

1997 • 34 citations

Are The Curves in all the Right Places?

2000 • 29 citations

THE MECHANISM OF BILIARY LIPID SECRETION AND ITS DEFECTS

1999 • 25 citations

Differential rate of cholesterol efflux from the apical and basolateral membranes of MDCK cells

1998 • 15 citations