Ceramide-Rich Membrane Rafts Mediate CD40 Clustering

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD95 Signaling via Ceramide-rich Membrane Rafts

2001 • 630 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen Targeting

1999 • 473 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Compartmentalization of ceramide signaling: physical foundations and biological effects

2000 • 421 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Localization of Platelet-derived Growth Factor-stimulated Phosphorylation Cascade to Caveolae

1996 • 378 citations

Ceramide Enables Fas to Cap and Kill

2001 • 377 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

1997 • 319 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

Sphingomyelinase Induces Lipid Microdomain Formation in a Fluid Phosphatidylcholine/Sphingomyelin Membrane

1998 • 276 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

1998 • 240 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor.

1996 • 237 citations

Ceramides in Phospholipid Membranes: Effects on Bilayer Stability and Transition to Nonlamellar Phases

1999 • 231 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

Recruitment of CD40 and Tumor Necrosis Factor Receptor-associated Factors 2 and 3 to Membrane Microdomains during CD40 Signaling

2000 • 201 citations

Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide

2000 • 194 citations

Molecular Mechanisms of Ceramide-Mediated CD95 Clustering

2001 • 191 citations

Compartmentalized IgE Receptor–mediated Signal Transduction in Living Cells

1997 • 189 citations

CD40-mediated signaling in B cells. Balancing cell survival, growth, and death.

1996 • 186 citations

CD40 signaling in human dendritic cells is initiated within membrane rafts

2000 • 183 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

1998 • 144 citations

Translocation of the B Cell Antigen Receptor into Lipid Rafts Reveals a Novel Step in Signaling

2001 • 142 citations

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.

1994 • 134 citations

Fas/CD95/Apo-I activates the acidic sphingomyelinase via Caspases

1998 • 127 citations

Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6) Stimulates Extracellular Signal–regulated Kinase (ERK) Activity in CD40 Signaling Along a Ras-independent Pathway

1998 • 120 citations

Acid sphingomyelinase is involved in CEACAM receptor‐mediated phagocytosis of Neisseria gonorrhoeae

2000 • 112 citations

Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers

1996 • 105 citations

The tyrosine kinase Lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation

1999 • 94 citations

CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells.

1996 • 94 citations

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes

1990 • 81 citations

Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells

1993 • 69 citations

Ceramides Modulate Protein Kinase C Activity and Perturb the Structure of Phosphatidylcholine/Phosphatidylserine Bilayers

1999 • 64 citations

Activation of the Ras signaling pathway by the CD40 receptor.

1996 • 53 citations

L-Selectin Stimulates the Neutral Sphingomyelinase and Induces Release of Ceramide

1998 • 31 citations

Localization of major potential substrates of p60v-src kinase in the plasma membrane matrix fraction.

1989 • 15 citations