Roles of Nectins in Cell Adhesion, Signaling and Polarization

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

2000 • 1,167 citations

The major human rhinovirus receptor is ICAM-1

1989 • 1,134 citations

Origins of Cell Polarity

1996 • 1,024 citations

Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

1998 • 905 citations

Signalling to and from tight junctions

2003 • 863 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Cadherin superfamily genes: functions, genomic organization, and neurologic diversity

2000 • 640 citations

Junction Adhesion Molecule Is a Receptor for Reovirus

2001 • 628 citations

The cadherin superfamily: diversity in form and function

2001 • 598 citations

WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell mov

2001 • 594 citations

Development of the mossy fibers of the dentate gyrus: I. A light and electron microscopic study of the mossy fibers and their expansions

1981 • 590 citations

Nectin and afadin: novel organizers of intercellular junctions

2002 • 574 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Mechanisms of Epithelial Cell–Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin– Green Fluorescent Protein

1998 • 527 citations

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein

1999 • 527 citations

New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity

1999 • 522 citations

Epithelial Cell Polarity and Cell Junctions inDrosophila

2001 • 516 citations

Three Classes of Cell Surface Receptors for Alphaherpesvirus Entry

2000 • 510 citations

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

1996 • 503 citations

A Cell Surface Protein with Herpesvirus Entry Activity (HveB) Confers Susceptibility to Infection by Mutants of Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, and Pseudorabies Virus

1998 • 497 citations

Cadherins in embryonic and neural morphogenesis

2000 • 482 citations

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

2003 • 476 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

1999 • 434 citations

Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundles.

1987 • 432 citations

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

2002 • 432 citations

Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

2001 • 421 citations

Cadherin Engagement Regulates Rho family GTPases

2001 • 421 citations

Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells

1995 • 393 citations

A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl

2003 • 368 citations

Molecular linkage between cadherins and actin filaments in cell—cell adherens junctions

1992 • 359 citations

Spatio-Temporal Regulation of Rac1 Localization and Lamellipodia Dynamics during Epithelial Cell-Cell Adhesion

2002 • 349 citations

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

2003 • 346 citations

Nectins and nectin‐like molecules: Roles in cell adhesion, migration, and polarization

2003 • 342 citations

A Role for the Cadherin Family of Cell Adhesion Molecules in Hippocampal Long-Term Potentiation

1998 • 336 citations

Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia

2000 • 327 citations

Cadherins and tissue formation: integrating adhesion and signaling

1999 • 318 citations

E-cadherin Homophilic Ligation Directly Signals through Rac and Phosphatidylinositol 3-Kinase to Regulate Adhesive Contacts

2002 • 315 citations

Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear.

1982 • 310 citations

Asymmetric cell division during animal development

2001 • 306 citations

Structural and signalling molecules come together at tight junctions

1999 • 306 citations

Nectin4/PRR4, a New Afadin-associated Member of the Nectin Family That Trans-interacts with Nectin1/PRR1 through V Domain Interaction

2001 • 298 citations

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

1998 • 297 citations

Molecular architecture of adherens junctions

2001 • 291 citations

Afadin

1999 • 282 citations

Nectin

2002 • 281 citations

Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites

2001 • 276 citations

Nectin-3, a New Member of Immunoglobulin-like Cell Adhesion Molecules That Shows Homophilic and Heterophilic Cell-Cell Adhesion Activities

2000 • 275 citations

Two Cell Adhesion Molecules, Nectin and Cadherin, Interact through Their Cytoplasmic Domain–Associated Proteins

2000 • 264 citations

The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells

2000 • 262 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Nectin Couples Cell-Cell Adhesion and the Actin Scaffold at Heterotypic Testicular Junctions

2002 • 247 citations

Ponsin/SH3P12: An l-Afadin– and Vinculin-binding Protein Localized at Cell–Cell and Cell–Matrix Adherens Junctions

1999 • 244 citations

Biochemical and Structural Definition of the l-Afadin- and Actin-binding Sites of α-Catenin

2002 • 236 citations

Lamina-specific expression of adhesion molecules in developing chick optic tectum

1995 • 229 citations

Cellular receptors for viruses: links to tropism and pathogenesis

2000 • 228 citations

The presynaptic cytomatrix of brain synapses

2001 • 220 citations

Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela

2001 • 202 citations

The Junction-associated Protein AF-6 Interacts and Clusters with Specific Eph Receptor Tyrosine Kinases at Specialized Sites of Cell–Cell Contact in the Brain

1999 • 195 citations

Unique and Multifunctional Adhesion Junctions in the Testis. Ectoplasmic Specializations.

2000 • 194 citations

The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene

1995 • 185 citations

Mammalian Homolog of Drosophila Tumor Suppressor Lethal (2) Giant Larvae Interacts with Basolateral Exocytic Machinery in Madin-Darby Canine Kidney Cells

2002 • 183 citations

MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

1997 • 182 citations

Direct Binding of Cell Polarity Protein PAR-3 to Cell-Cell Adhesion Molecule Nectin at Neuroepithelial Cells of Developing Mouse

2003 • 172 citations

Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity

1999 • 167 citations

Defects in Nuclear and Cytoskeletal Morphology and Mitochondrial Localization in Spermatozoa of Mice Lacking Nectin-2, a Component of Cell-Cell Adherens Junctions

2000 • 166 citations

Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

1995 • 163 citations

Interaction of Nectin with Afadin Is Necessary for Its Clustering at Cell-Cell Contact Sites but Not for Itscis Dimerization or trans Interaction

2000 • 155 citations

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo

1996 • 149 citations

Rac Activation upon Cell-Cell Contact Formation Is Dependent on Signaling from the Epidermal Growth Factor Receptor

2002 • 146 citations

Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene

1992 • 144 citations

Axon guidance at choice points

1998 • 136 citations

The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D

1998 • 128 citations

Development of Sertoli cell junctional specializations and the distribution of the tight‐junction‐associated protein ZO‐1 in the mouse testis

1991 • 127 citations

Loss of Nectin-2 at Sertoli-Spermatid Junctions Leads to Male Infertility and Correlates with Severe Spermatozoan Head and Midpiece Malformation, Impaired Binding to the Zona Pellucida, and Oocyte Penetration

2003 • 126 citations

Involvement of nectin in the localization of junctional adhesion molecule at tight junctions

2002 • 123 citations

Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)

2000 • 112 citations

Genetic control of epithelial cell polarity: Lessons fromDrosophila

2000 • 110 citations

Immunoglobulin superfamily receptors: cis-interactions, intracellular adapters and alternative splicing regulate adhesion

2001 • 106 citations

trans-Interactions of Nectins Induce Formation of Filopodia and Lamellipodia through the Respective Activation of Cdc42 and Rac Small G Proteins

2002 • 105 citations

Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells

1999 • 105 citations

Sertoli cell ectoplasmic specializations: a type of actin-associated adhesion junction?

1989 • 102 citations

ADIP, a Novel Afadin- and α-Actinin-Binding Protein Localized at Cell-Cell Adherens Junctions

2003 • 100 citations

Similar and differential behaviour between the nectin‐afadin‐ponsin and cadherin‐catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells

1999 • 95 citations

α-Catenin-independent Recruitment of ZO-1 to Nectin-based Cell-Cell Adhesion Sites through Afadin

2001 • 92 citations

Pathfinding by growth cones of commissural interneurons in the chick embryo spinal cord: A light and electron microscopic study

1991 • 90 citations

Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E‐cadherin‐based cell‐cell adhesion

2003 • 90 citations

Requirement of Interaction of Nectin-1α/HveC with Afadin for Efficient Cell-Cell Spread of Herpes Simplex Virus Type 1

2001 • 90 citations

Dynamic Testicular Adhesion Junctions Are Immunologically Unique. II. Localization of Classic Cadherins in Rat Testis1

2002 • 86 citations

Role of nectin in organization of tight junctions in epithelial cells

2002 • 85 citations

Different behavior of l-Afadin and Neurabin-II during the formation and destruction of cell – cell adherens junction

1999 • 82 citations

βPix-enhanced p38 Activation by Cdc42/Rac/PAK/MKK3/6-mediated Pathway

2001 • 81 citations

Involvement of Nectin-activated Cdc42 Small G Protein in Organization of Adherens and Tight Junctions in Madin-Darby Canine Kidney Cells

2003 • 80 citations

The roles of cadherins and nectins in interneuronal synapse formation

2003 • 79 citations

Principles of glutamatergic synapse formation: seeing the forest for the trees

2001 • 74 citations

Expression and localization of N‐ and E‐cadherin in the human testis and epididymis

1994 • 71 citations

Ectoplasmic (“Junctional”) Specializations in Mammalian Sertoli Cells: Influence on Spermatogenic Cells^a

1991 • 64 citations

Evidence that vinculin is co‐distributed with actin bundles in ectoplasmic (“junctional”) specializations of mammalian sertoli cells

1991 • 62 citations

Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry

2001 • 61 citations

Role of each immunoglobulin-like loop of nectin for its cell–cell adhesion activity

2003 • 59 citations

Role of the second immunoglobulin-like loop of nectin in cell–cell adhesion

2002 • 53 citations

Cdc42 and Rac small G proteins activated by trans‐interactions of nectins are involved in activation of c‐Jun N‐terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts

2003 • 48 citations

Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection

2001 • 47 citations

Localization of l-afadin at puncta adhaerentia-like junctions between the mossy fiber terminals and the dendritic trunks of pyramidal cells in the adult mouse hippocampus

2000 • 47 citations

Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions

2003 • 44 citations

Roles of the Intercellular Adhesion Molecule Nectin in Intracellular Signaling

2003 • 44 citations

Identification and developmental regulation of cadherin messenger ribonucleic acids in the rat testis

1992 • 33 citations

Role of Nectin in Formation of E-Cadherin–based Adherens Junctions in Keratinocytes: Analysis with the N-Cadherin Dominant Negative Mutant

2003 • 31 citations

Viral Interactions with Receptors in Cell Junctions and Effects on Junctional Stability

2002 • 22 citations

Restoration of E-cadherin-based cell–cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line

2002 • 21 citations