Role of nectin in organization of tight junctions in epithelial cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

1998 • 905 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Regulation of Cadherin Adhesive Activity

2000 • 793 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Occludin and claudins in tight-junction strands: leading or supporting players?

1999 • 575 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein

1999 • 527 citations

Human junction adhesion molecule regulates tight junction resealing in epithelia

2000 • 521 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

Three Classes of Cell Surface Receptors for Alphaherpesvirus Entry

2000 • 510 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

A Cell Surface Protein with Herpesvirus Entry Activity (HveB) Confers Susceptibility to Infection by Mutants of Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, and Pseudorabies Virus

1998 • 497 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

Protein Interactions at the Tight Junction

1999 • 470 citations

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

2000 • 469 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Junctional Adhesion Molecule Interacts with the PDZ Domain-containing Proteins AF-6 and ZO-1

2000 • 426 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

2001 • 387 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Junctional adhesion molecule (JAM) binds to PAR-3

2001 • 379 citations

Molecular linkage between cadherins and actin filaments in cell—cell adherens junctions

1992 • 359 citations

α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

1998 • 338 citations

Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia

2000 • 327 citations

Structural and signalling molecules come together at tight junctions

1999 • 306 citations

Characterization of ZO-2 as a MAGUK Family Member Associated with Tight as well as Adherens Junctions with a Binding Affinity to Occludin and α Catenin

1999 • 302 citations

Nectin4/PRR4, a New Afadin-associated Member of the Nectin Family That Trans-interacts with Nectin1/PRR1 through V Domain Interaction

2001 • 298 citations

Afadin

1999 • 282 citations

Nectin

2002 • 281 citations

Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells.

1999 • 280 citations

Nectin-3, a New Member of Immunoglobulin-like Cell Adhesion Molecules That Shows Homophilic and Heterophilic Cell-Cell Adhesion Activities

2000 • 275 citations

Two Cell Adhesion Molecules, Nectin and Cadherin, Interact through Their Cytoplasmic Domain–Associated Proteins

2000 • 264 citations

The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells

2000 • 262 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Nectin Couples Cell-Cell Adhesion and the Actin Scaffold at Heterotypic Testicular Junctions

2002 • 247 citations

Ponsin/SH3P12: An l-Afadin– and Vinculin-binding Protein Localized at Cell–Cell and Cell–Matrix Adherens Junctions

1999 • 244 citations

Vascular Endothelial Junction-associated Molecule, a Novel Member of the Immunoglobulin Superfamily, Is Localized to Intercellular Boundaries of Endothelial Cells

2000 • 239 citations

Cutting Edge: Combined Treatment of TNF-α and IFN-γ Causes Redistribution of Junctional Adhesion Molecule in Human Endothelial Cells

1999 • 230 citations

Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. II. Morphological analysis.

1988 • 194 citations

The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene

1995 • 185 citations

Endocytosis of junctional cadherins in bovine kidney epithelial (MDBK) cells cultured in low Ca2+ ion medium.

1991 • 173 citations

Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells.

1988 • 165 citations

The Human Poliovirus Receptor Related 2 Protein Is a New Hematopoietic/Endothelial Homophilic Adhesion Molecule

1998 • 164 citations

Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

1995 • 163 citations

Interaction of Nectin with Afadin Is Necessary for Its Clustering at Cell-Cell Contact Sites but Not for Itscis Dimerization or trans Interaction

2000 • 155 citations

The cytoplasmic domain of adherens‐type junctions

1991 • 151 citations

Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene

1992 • 144 citations

Nectin2α (PRR2α or HveB) and Nectin2δ Are Low-Efficiency Mediators for Entry of Herpes Simplex Virus Mutants Carrying the Leu25Pro Substitution in Glycoprotein D

2000 • 136 citations

The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D

1998 • 128 citations

Involvement of nectin in the localization of junctional adhesion molecule at tight junctions

2002 • 123 citations

Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis.

1988 • 119 citations

Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)

2000 • 112 citations

Sorting of Membrane and Fluid at the Apical Pole of Polarized Madin-Darby Canine Kidney Cells

2000 • 98 citations

Similar and differential behaviour between the nectin‐afadin‐ponsin and cadherin‐catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells

1999 • 95 citations

α-Catenin-independent Recruitment of ZO-1 to Nectin-based Cell-Cell Adhesion Sites through Afadin

2001 • 92 citations

Requirement of Interaction of Nectin-1α/HveC with Afadin for Efficient Cell-Cell Spread of Herpes Simplex Virus Type 1

2001 • 90 citations

Amino acid residues on human poliovirus receptor involved in interaction with poliovirus.

1994 • 87 citations

Exogenous Expression of the Amino-Terminal Half of the Tight Junction Protein Zo-3 Perturbs Junctional Complex Assembly

2000 • 54 citations

Role of the second immunoglobulin-like loop of nectin in cell–cell adhesion

2002 • 53 citations

Localization of l-afadin at puncta adhaerentia-like junctions between the mossy fiber terminals and the dendritic trunks of pyramidal cells in the adult mouse hippocampus

2000 • 47 citations

Localization of mLin-7 at nectin-based cell–cell junctions

2002 • 16 citations

cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney

1994 • 14 citations