Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Protein modules and signalling networks

1995 • 2,447 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Cytokine receptor signalling

1995 • 1,242 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Serine/threonine protein phosphatases

1995 • 635 citations

Modulation of Cellular Thermoresistance and Actin Filament Stability Accompanies Phosphorylation-Induced Changes in the Oligomeric Structure of Heat Shock Protein 27

1995 • 631 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Phospholipid signaling

1995 • 561 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

A role for Rho in Ras transformation.

1995 • 538 citations

The ins and outs of Raf kinases

1994 • 537 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

1994 • 411 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

The family of G‐protein‐coupled receptors

1995 • 369 citations

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

1995 • 368 citations

Recognition and specificity in protein tyrosine kinase-mediated signalling

1995 • 367 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

The Ras signal transduction pathway

1994 • 345 citations

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

1994 • 342 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Ras target proteins in eukaryotic cells

1995 • 316 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Src family protein tyrosine kinases and cellular signal transduction pathways

1995 • 298 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

1994 • 292 citations

A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.

1994 • 278 citations

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors

1995 • 267 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

An emerging family of dual specificity MAP kinase phosphatases

1995 • 256 citations

14-3-3 proteins on the MAP

1995 • 255 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

1995 • 253 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

Protein kinase C and its substrates

1996 • 236 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1995 • 226 citations

Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase

1995 • 223 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms

1995 • 221 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner

1995 • 217 citations

Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells

1995 • 216 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.

1993 • 205 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1995 • 202 citations

Bcr and Raf form a complex in vivo via 14-3-3 proteins.

1995 • 201 citations

Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor

1995 • 201 citations

A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function

1995 • 196 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

JAK2, Ras, and Raf Are Required for Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase by Growth Hormone

1995 • 194 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

1995 • 187 citations

The GRB2/Sem‐5 adaptor protein

1994 • 182 citations

SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways

1996 • 180 citations

Ras-Dependent and -Independent Pathways Target the Mitogen-Activated Protein Kinase Network in Macrophages

1995 • 179 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 • 177 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Rho-related proteins: actin cytoskeleton and cell cycle

1995 • 176 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes.

1995 • 174 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.

1993 • 159 citations

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1995 • 158 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.

1995 • 157 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.

1995 • 139 citations

c-SRC Phosphorylates Epidermal Growth Factor Receptor on Tyrosine 845

1995 • 139 citations

Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.

1996 • 134 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

1996 • 130 citations

Characterization of the Interaction between RhoGDI and Cdc42Hs Using Fluorescence Spectroscopy

1996 • 129 citations

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.

1994 • 128 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

1995 • 122 citations

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

1994 • 121 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.

1994 • 117 citations

Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells

1995 • 114 citations

A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions.

1994 • 113 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal Neurons

1996 • 109 citations

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

1995 • 106 citations

Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.

1994 • 101 citations

Disassembly of Son-of-sevenless Proteins from Grb2 during p21 Desensitization by Insulin

1995 • 99 citations

Binding of NCK to SOS and Activation of ras-Dependent Gene Expression

1995 • 94 citations

Ste5: a meeting place for MAP kinases and their associates

1995 • 93 citations

Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.

1994 • 91 citations

Differential Modulation of Mitogen-activated Protein (MAP) Kinase/Extracellular Signal-related Kinase Kinase and MAP Kinase Activities by a Mutant Epidermal Growth Factor Receptor

1995 • 87 citations

Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues.

1995 • 86 citations

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

1995 • 85 citations

Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors

1994 • 82 citations

A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains

1995 • 81 citations

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

1995 • 80 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

Protein phosphatases

1995 • 79 citations

Molecular Cloning and Sequencing of the Cytostatic G Protein-activated Protein Kinase PAK I

1996 • 77 citations

Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites

1993 • 76 citations

Evidence for cell-specific differences in transformation by N-, H- and K-ras.

1995 • 75 citations

Evidence for a Bifurcation of the Mitogenic Signaling Pathway Activated by Ras and Phosphatidylcholine-hydrolyzing Phospholipase C

1995 • 73 citations

Interactions between the Protein-tyrosine Kinase ZAP-70, the Proto-oncoprotein Vav, and Tubulin in Jurkat T Cells

1995 • 71 citations

Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

1994 • 69 citations

Ras Is Not Required for the Interleukin 3-induced Proliferation of a Mouse Pro-B Cell Line, BaF3

1995 • 68 citations

Signal transduction pathways involving RAS

1994 • 63 citations

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.

1996 • 62 citations

Mutations that abolish the ability of Ha-Ras to associate with Raf-1.

1994 • 58 citations

Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo.

1995 • 58 citations

Complete Nucleotide Sequence, Expression, and Chromosomal Localisation of Human Mixed-Lineage Kinase 2

1995 • 52 citations

Dominant-negative Mutants of Grb2 Induced Reversal of the Transformed Phenotypes Caused by the Point Mutation-activated Rat HER-2/Neu

1995 • 51 citations

Differential Activation of PKC Isozymes by 14-3-3 ζ Protein

1995 • 49 citations

Preferential Involvement of MEK1 in the Tumor Necrosis Factor-α-induced Activation of p42mapk/erk2 in Mouse Macrophages

1995 • 49 citations

Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast

1995 • 49 citations

Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.

1995 • 47 citations

Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.

1995 • 46 citations

Pleckstrin Inhibits Phosphoinositide Hydrolysis Initiated by G-protein-coupled and Growth Factor Receptors. A ROLE FOR PLECKSTRIN'S PH DOMAINS

1995 • 45 citations

Cell Type-specific Modulation of Cell Growth by Transforming Growth Factor β1 Does Not Correlate with Mitogen-activated Protein Kinase Activation

1995 • 43 citations

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

1993 • 42 citations

Nerve Growth Factor-induced Growth Arrest and Induction of p21 in NIH-3T3 Cells Expressing TrkA

1995 • 40 citations

Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells.

1995 • 35 citations

G protein pathways: signal processing by effectors

1994 • 34 citations

Epidermal Growth Factor Induces Phosphorylation of Extracellular Signal-Regulated Kinase 2 via Multiple Pathways

1993 • 32 citations

Binding of Shc to the NPXY Motif Is Mediated by Its N-terminal Domain

1995 • 31 citations

Regulation of ras signal transduction in normal and transformed cells

1994 • 30 citations

Expression of a Catalytically Inert SYP Blocks Activation of Map Kinase Pathway Downstream of P21ras

1995 • 23 citations

The Mitogen-Activated Protein Kinase Cascade Is Activated by B-Raf in Response to Nerve Growth Factor through Interaction with p21^ras

1994 • 22 citations

Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells.

1995 • 21 citations

A Novel Mammalian Ras GTPase-Activating Protein Which Has Phospholipid-Binding and Btk Homology Regions

1994 • 21 citations

RAS and RAF-1 Form a Signalling Complex with MEK-1 but Not MEK-2

1994 • 21 citations

Shc associates with an unphosphorylated form of the p21ras guanine nucleotide exchange factor mSOS.

1995 • 17 citations

Cloning and Characterization of p97^MAPK, a Novel Human Homolog of Rat ERK-3

1994 • 15 citations

A Conserved Region of c-Ha-Ras Is Required for Efficient GTPase Stimulation by GTPase Activating Protein but Not Neurofibromin

1995 • 9 citations

Phosphorylation and Activation of p90rsk by Glycogen Synthase Kinase-3

1995 • 3 citations