Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Origins of Cell Polarity

1996 • 1,024 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Drosophila Atypical Protein Kinase C Associates with Bazooka and Controls Polarity of Epithelia and Neuroblasts

2000 • 467 citations

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts

1999 • 450 citations

Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

2001 • 426 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

2000 • 405 citations

The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

2001 • 387 citations

Junctional adhesion molecule (JAM) binds to PAR-3

2001 • 379 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts

1999 • 375 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Analysis of partner of inscuteable, a Novel Player of Drosophila Asymmetric Divisions, Reveals Two Distinct Steps in Inscuteable Apical Localization

2000 • 364 citations

Asymmetric cell division during animal development

2001 • 306 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex

2001 • 300 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

Molecular architecture of adherens junctions

2001 • 291 citations

The Drosophila Homolog of C. elegans PAR-1 Organizes the Oocyte Cytoskeleton and Directs oskar mRNA Localization to the Posterior Pole

2000 • 291 citations

Actin dynamics and cell–cell adhesion in epithelia

2001 • 288 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos

2001 • 262 citations

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

2001 • 256 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

MEX-5 and MEX-6 Function to Establish Soma/Germline Asymmetry in Early C. elegans Embryos

2000 • 252 citations

PARsing Embryonic Polarity

2000 • 248 citations

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka

1998 • 233 citations

Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62

1998 • 230 citations

CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 • 222 citations

The atypical protein kinase Cs

2000 • 217 citations

E-cadherin-mediated Cell-Cell Attachment Activates Cdc42

2000 • 214 citations

Apical, basal, and lateral cues for epithelial polarization

1995 • 181 citations

Polarization of the anterior–posterior axis of C. elegans is a microtubule-directed process

2000 • 177 citations

Tight Junction, a Platform for Trafficking and Signaling Protein Complexes

2000 • 175 citations

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation

2000 • 173 citations

EARLY PATTERNING OF THE C. ELEGANS EMBRYO

1998 • 173 citations

Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

1997 • 168 citations

Asymmetric cell division: fly neuroblast meets worm zygote

2001 • 160 citations

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

2001 • 154 citations

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote

2000 • 153 citations

G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos

1996 • 151 citations

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

2000 • 145 citations

The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans

1999 • 140 citations

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

2001 • 138 citations

Drosophila par-1 is required for oocyte differentiation and microtubule organization

2001 • 137 citations

Genetic control of epithelial cell polarity: Lessons fromDrosophila

2000 • 110 citations

PAR-1 is required for the maintenance of oocyte fate in Drosophila

2001 • 106 citations

Polarity in Cell Division

2000 • 79 citations

Patterning the C. elegans embryo: moving beyond the cell lineage

1999 • 68 citations

Mutations in ooc-5 and ooc-3 Disrupt Oocyte Formation and the Reestablishment of Asymmetric PAR Protein Localization in Two-Cell Caenorhabditis elegans Embryos

1999 • 67 citations

Epithelial differentiation in Drosophila

1997 • 65 citations

Asymmetric division of Drosophila neural stem cells: a basis for neural diversity

2000 • 63 citations

Cell polarity in the early Caenorhabditis elegans embryo

1999 • 56 citations

pod-2, along with pod-1, Defines a New Class of Genes Required for Polarity in the Early Caenorhabditis elegans Embryo

2001 • 49 citations

Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes

2000 • 45 citations

Pattern formation in single cells

1999 • 41 citations

OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P1 blastomere of C. elegans embryos

2000 • 35 citations

Cell polarity: Squaring the circle

2001 • 30 citations

Epithelial polarity: The ins and outs of the fly epidermis

2000 • 20 citations

Embryonic polarity: A role for microtubules

2000 • 19 citations