Activation of the JNK signaling pathway: Breaking the brake on apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

AP-1 function and regulation

1997 • 2,833 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

2001 • 1,427 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

1999 • 997 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

c-Jun is essential for normal mouse development and hepatogenesis

1993 • 543 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

1999 • 357 citations

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

2001 • 349 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Role of MEKK1 in Cell Survival and Activation of JNK and ERK Pathways Defined by Targeted Gene Disruption

1998 • 322 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

The Mammalian UV Response

2000 • 295 citations

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

2000 • 279 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

1998 • 234 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

2001 • 223 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

2001 • 219 citations

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

1998 • 196 citations

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7

2000 • 190 citations

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

2002 • 169 citations

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

2002 • 166 citations

Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4

1999 • 153 citations

The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells

1999 • 146 citations

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.

1992 • 138 citations

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

2002 • 138 citations

Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner

2000 • 138 citations

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

2002 • 127 citations

Programmed cell death in the absence of c-Fos and c-Jun

1996 • 127 citations

NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

2001 • 121 citations

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38

1997 • 120 citations

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity

1999 • 110 citations

Elevated JNK activation contributes to the pathogenesis of human brain tumors

2002 • 104 citations

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

1999 • 97 citations

The JNK/c-Jun cascade and Alzheimer's disease

2002 • 84 citations

JNK3 contributes to c‐Jun activation and apoptosis but not oxidative stress in nerve growth factor‐deprived sympathetic neurons

2001 • 74 citations

Dopamine D1 receptor interaction with arrestin3 in neostriatal neurons

2005 • 63 citations

Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation

2002 • 58 citations

Errors of homeostasis and deregulated apoptosis

1997 • 53 citations

Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.

2002 • 53 citations

Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells

1999 • 47 citations

A prokaryotic tRNATyr gene, inactive in Xenopus laevis oocytes, is activated by recombination with an eukaryotic tRNAPro gene.

1982 • 6 citations