Recent Advances in Stem Cell Neurobiology

Embryonic Stem Cell Lines Derived from Human Blastocysts

1998 • 15,541 citations

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Viable offspring derived from fetal and adult mammalian cells

1997 • 4,774 citations

Mammalian Neural Stem Cells

2000 • 4,689 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

1965 • 3,461 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

2000 • 2,733 citations

Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease

2001 • 2,290 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

2002 • 2,028 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

1997 • 1,878 citations

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

1999 • 1,872 citations

Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

2000 • 1,859 citations

Direct isolation of human central nervous system stem cells

2000 • 1,822 citations

Dystrophin expression in the mdx mouse restored by stem cell transplantation

1999 • 1,817 citations

Out of Eden: Stem Cells and Their Niches

2000 • 1,769 citations

From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

2000 • 1,709 citations

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

1999 • 1,647 citations

Changing potency by spontaneous fusion

2002 • 1,525 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

Stem Cells in the Central Nervous System

1997 • 1,483 citations

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

1999 • 1,437 citations

Neurogenesis in Adult Subventricular Zone

2002 • 1,415 citations

Derivation of pluripotent stem cells from cultured human primordial germ cells

1998 • 1,415 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell

1996 • 1,366 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

Neurogenesis in the Neocortex of Adult Primates

1999 • 1,268 citations

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells

2000 • 1,262 citations

Liver from bone marrow in humans

2000 • 1,250 citations

Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat

1993 • 1,215 citations

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

1999 • 1,212 citations

Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis

1996 • 1,209 citations

Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

1997 • 1,206 citations

Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas

2000 • 1,202 citations

Induction of neurogenesis in the neocortex of adult mice

2000 • 1,201 citations

Embryonic Stem Cells Express Neuronal Properties in Vitro

1995 • 1,173 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

2000 • 1,132 citations

Neural progenitors from human embryonic stem cells

2001 • 1,113 citations

The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

1997 • 1,080 citations

Regulatory Mechanisms in Stem Cell Biology

1997 • 1,060 citations

Hepatocytes from non-hepatic adult stem cells

2000 • 1,034 citations

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

1996 • 1,027 citations

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

1995 • 1,014 citations

Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

1999 • 981 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

1979 • 963 citations

Hematopoietic potential of stem cells isolated from murine skeletal muscle

1999 • 960 citations

Estrogen Stimulates a Transient Increase in the Number of New Neurons in the Dentate Gyrus of the Adult Female Rat

1999 • 958 citations

Cell replacement therapies for central nervous system disorders

2000 • 948 citations

Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

1992 • 928 citations

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

1999 • 916 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

2000 • 868 citations

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

1995 • 857 citations

The neural basis of cognitive development: A constructivist manifesto

1997 • 849 citations

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory

1999 • 840 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

Hippocampal neurogenesis in adult Old World primates

1999 • 804 citations

Neurogenesis in the adult brain: death of a dogma

2000 • 796 citations

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 • 787 citations

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

1998 • 776 citations

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

1996 • 775 citations

Synaptic Efficacy Enhanced by Glial Cells in Vitro

1997 • 771 citations

Stem Cells

2000 • 767 citations

Continuation of neurogenesis in the hippocampus of the adult macaque monkey

1999 • 765 citations

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

1998 • 725 citations

Restoring production of hippocampal neurons in old age

1999 • 717 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

Epigenetic Instability in ES Cells and Cloned Mice

2001 • 713 citations

Gene therapy: trials and tribulations

2000 • 701 citations

Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus

2000 • 697 citations

FGF-2-Responsive Neuronal Progenitors Reside in Proliferative and Quiescent Regions of the Adult Rodent Brain

1995 • 691 citations

Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

1999 • 687 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Inductive interactions direct early regionalization of the mouse forebrain

1997 • 651 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 • 646 citations

Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo

1996 • 626 citations

Transplantation of cultured human neuronal cells for patients with stroke

2000 • 622 citations

Widespread Dispersion of Neuronal Clones Across Functional Regions of the Cerebral Cortex

1992 • 610 citations

Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia

2002 • 607 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

Rapid extension of axons into the CA3 region by adult-generated granule cells

1999 • 597 citations

Opiates inhibit neurogenesis in the adult rat hippocampus

2000 • 590 citations

Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation

2000 • 578 citations

A self-renewing multipotential stem cell in embryonic rat cerebral cortex

1994 • 578 citations

A new method for the rapid and long term growth of human neural precursor cells

1998 • 572 citations

Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a Recombinant Retrovirus

1988 • 569 citations

Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

1999 • 562 citations

Isolation and Cloning of Multipotential Stem Cells from the Embryonic Human CNS and Establishment of Transplantable Human Neural Stem Cell Lines by Epigenetic Stimulation

1999 • 562 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

Differentiation of Embryonic Stem Cell Lines Generated from Adult Somatic Cells by Nuclear Transfer

2001 • 560 citations

In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus

2000 • 559 citations

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

1998 • 539 citations

De novo generation of neuronal cells from the adult mouse brain.

1992 • 535 citations

Initiation of neural induction by FGF signalling before gastrulation

2000 • 519 citations

Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors

2002 • 516 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

In Vitro Expansion of a Multipotent Population of Human Neural Progenitor Cells

1999 • 501 citations

3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb

1983 • 501 citations

Skeletal myogenic potential of human and mouse neural stem cells

2000 • 485 citations

Regulation of neurogenesis by growth factors and neurotransmitters

1998 • 483 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

2002 • 480 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

Neural progenitor cell engraftment corrects lysosomal storage throughout the MRS VII mouse brain

1995 • 475 citations

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

1991 • 474 citations

Asymmetric Cell Division

2006 • 469 citations

Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis

2002 • 464 citations

Generation of purified neural precursors from embryonic stem cells by lineage selection

1998 • 463 citations

Progenitor cells from human brain after death

2001 • 460 citations

Gene therapy of experimental brain tumors using neural progenitor cells

2000 • 459 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

2000 • 452 citations

Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease

1997 • 449 citations

Neurons Generated in the Adult Brain Are Recruited into Functional Circuits

1984 • 445 citations

Replicative Senescence: An Old Lives' Tale?

1996 • 429 citations

Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

2000 • 426 citations

In vitro differentiation of embryonic stem cells into glial cells and functional neurons

1995 • 426 citations

Septal transplants restore maze learning in rats with fornix-fimbria lesions

1982 • 414 citations

Fetal Nigral Transplantation as a Therapy for Parkinson’s Disease

2006 • 411 citations

Division and differentiation of isolated CNS blast cells in microculture

1989 • 404 citations

Regulation of hippocampal neurogenesis in adulthood

2000 • 402 citations

Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations

2002 • 396 citations

Adult-generated hippocampal and neocortical neurons in macaques have a transient existence

2001 • 394 citations

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b

2000 • 393 citations

Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus

1998 • 385 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

1999 • 373 citations

Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells

1997 • 369 citations

Stem Cells in Epithelial Tissues

2000 • 367 citations

Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons

1998 • 365 citations

Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system

1997 • 364 citations

Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain

1999 • 361 citations

Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons

1995 • 361 citations

A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons

1997 • 359 citations

Immunosuppressive drugs: the first 50 years and a glance forward

2000 • 346 citations

Growth factors regulate the survival and fate of cells derived from human neurospheres

2001 • 343 citations

Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.

2000 • 341 citations

BDNF enhances the differentiation but not the survival of CNS stem cell- derived neuronal precursors

1995 • 340 citations

The Notch-Hes pathway in mammalian neural development

1999 • 340 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Cyclosporin A Attenuates Acute Mitochondrial Dysfunction Following Traumatic Brain Injury

1999 • 336 citations

Response Diversity and the Timing of Progenitor Cell Maturation Are Regulated by Developmental Changes in EGFR Expression in the Cortex

1997 • 329 citations

Parthenogenetic Stem Cells in Nonhuman Primates

2002 • 316 citations

Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System

1996 • 314 citations

Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro

2000 • 314 citations

Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.

1992 • 313 citations

In vitro -generated neural precursors participate in mammalian brain development

1997 • 313 citations

The bHLH GeneHes1as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 311 citations

Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

2000 • 309 citations

Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons

1995 • 307 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

Neuroprotection through Delivery of Glial Cell Line-Derived Neurotrophic Factor by Neural Stem Cells in a Mouse Model of Parkinson's Disease

2001 • 303 citations

Adult Neurogenesis in Mammals: An Identity Crisis

2002 • 303 citations

FGF-2-Responsive Neural Stem Cell Proliferation Requires CCg, a Novel Autocrine/Paracrine Cofactor

2000 • 302 citations

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease

1997 • 301 citations

Neuroepithelial Stem Cells from the Embryonic Spinal Cord: Isolation, Characterization, and Clonal Analysis

1997 • 298 citations

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

1998 • 298 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Widespread Integration and Survival of Adult-Derived Neural Progenitor Cells in the Developing Optic Retina

1998 • 296 citations

Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

1998 • 295 citations

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

1998 • 295 citations

Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease

2000 • 293 citations

Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2

1998 • 292 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents

1986 • 284 citations

Why Stem Cells?

2000 • 282 citations

Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex

2001 • 277 citations

Long-Term Proliferation and Dopaminergic Differentiation of Human Mesencephalic Neural Precursor Cells

2001 • 276 citations

The generation of neurons and oligodendrocytes from a common precursor cell

1991 • 274 citations

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites

2000 • 273 citations

Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1991 • 261 citations

Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2

2001 • 259 citations

Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts

1990 • 259 citations

Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology

2000 • 259 citations

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.

1989 • 258 citations

Phage display in pharmaceutical biotechnology

2000 • 254 citations

Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors

1996 • 252 citations

Stem cells — hype and hope

2000 • 250 citations

Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro

1991 • 246 citations

Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor

1998 • 245 citations

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

1991 • 245 citations

Cellular immune response to adenoviral vector infected cells does not requirede novoviral gene expression: Implications for gene therapy

1998 • 244 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF

1995 • 238 citations

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain

2002 • 232 citations

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

2001 • 229 citations

Segregation of Human Neural Stem Cells in the Developing Primate Forebrain

2001 • 228 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon

2000 • 225 citations

Neural induction

2000 • 224 citations

4 Primate Embryonic Stem Cells

1997 • 220 citations

New prospects for human stem-cell therapy in the nervous system

1999 • 219 citations

Expression of human β–hexosaminidase α–subunit gene (the gene defect of Tay–Sachs disease) in mouse brains upon engraftment of transduced progenitor cells

1996 • 218 citations

Immortalized neural progenitor cells for CNS gene transfer and repair

1997 • 216 citations

Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

1999 • 215 citations

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 • 211 citations

Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway

2000 • 208 citations

Host-guided migration allows targeted introduction of neurons into the embryonic brain

1995 • 206 citations

Long-term correction of rat model of Parkinson's disease by gene therapy

1993 • 206 citations

Lineage-Restricted Neural Precursors Can Be Isolated from Both the Mouse Neural Tube and Cultured ES Cells

1999 • 206 citations

Cell Contact Regulates Fate Choice by Cortical Stem Cells

2000 • 205 citations

A Glia-Derived Signal Regulating Neuronal Differentiation

2000 • 205 citations

Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm

2000 • 204 citations

Human Neural Stem Cells: Isolation, Expansion and Transplantation

1999 • 203 citations

Regional specification of rodent and human neurospheres

2002 • 202 citations

Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6‐hydroxydopamine lesioned adult rats

1992 • 202 citations

Blastula-Stage Stem Cells Can Differentiate into Dopaminergic and Serotonergic Neurons after Transplantation

1998 • 201 citations

Lentiviral Gene Transfer to the Nonhuman Primate Brain

1999 • 198 citations

Regional incorporation and site-specific differentiation of striatal precursors transplanted to the embryonic forebrain ventricle

1995 • 198 citations

Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor

1998 • 195 citations

Correct Coordination of Neuronal Differentiation Events in Ventral Forebrain Requires the bHLH Factor MASH1

1999 • 193 citations

Survival, Integration, and Differentiation of Neural Stem Cell Lines after Transplantation to the Adult Rat Striatum

1997 • 191 citations

Continuous Infusion of Cyclosporin A Postinjury Significantly Ameliorates Cortical Damage Following Traumatic Brain Injury

2000 • 190 citations

Spinal Cord Neuronal Precursors Generate Multiple Neuronal Phenotypes in Culture

1998 • 189 citations

Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells

1999 • 189 citations

BMP and FGF regulate the development of EGF-responsive neural progenitor cells

2000 • 187 citations

Functional reactivation of the deafferented neostriatum by nigral transplants

1981 • 187 citations

Transplantation of Human Neural Progenitor Cells into the Neonatal Rat Brain: Extensive Migration and Differentiation with Long-Distance Axonal Projections

2002 • 186 citations

A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

1997 • 185 citations

Lack of Replicative Senescence in Normal Rodent Glia

2001 • 182 citations

Positioning the isthmic organizer

2000 • 181 citations

Chapter 13 Clinical observations after neural transplantation in Parkinson's disease

2000 • 179 citations

Young neurons from the adult subependymal zone proliferate and migrate along an astrocyte, extracellular matrix-rich pathway

1996 • 178 citations

Why Are Some Neurons Replaced in Adult Brain?

2002 • 178 citations

Polysialylated Neural Cell Adhesion Molecule-Positive CNS Precursors Generate Both Oligodendrocytes and Schwann Cells to Remyelinate the CNS after Transplantation

1999 • 177 citations

Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells

1996 • 172 citations

Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival

2000 • 172 citations

Establishment and Properties of Neural Stem Cell Clones: Plasticity In Vitro and In Vivo

1999 • 172 citations

Adult neurogenesis: from canaries to the clinic.

1998 • 171 citations

Hox homeobox genes and regionalisation of the nervous system

1993 • 170 citations

Stem cells and cellular pedigrees – a conceptual introduction

1997 • 167 citations

Multiple restricted lineages in the embryonic rat cerebral cortex

1993 • 166 citations

Striatal precursors adopt cortical identities in response to local cues

1995 • 164 citations

Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene.

1996 • 163 citations

Human therapeutic cloning

1999 • 161 citations

Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses

1995 • 160 citations

Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

1995 • 160 citations

Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease

2000 • 159 citations

Functional integration of striatal allografts in a primate model of Huntington's disease

1998 • 159 citations

Stem cells in the developing and adult nervous system

1998 • 155 citations

Immortalization of Neural Cells Via Retrovirus-Mediated Oncogene Transduction

1989 • 151 citations

Separate Proliferation Kinetics of Fibroblast Growth Factor-Responsive and Epidermal Growth Factor-Responsive Neural Stem Cells within the Embryonic Forebrain Germinal Zone

2000 • 151 citations

The immune response to intracerebral neural grafts

1991 • 147 citations

Mitogen and Substrate Differentially Affect the Lineage Restriction of Adult Rat Subventricular Zone Neural Precursor Cell Populations

1999 • 145 citations

A Clonal Line of Mesencephalic Progenitor Cells Converted to Dopamine Neurons by Hematopoietic Cytokines: A Source of Cells for Transplantation in Parkinson's Disease

2001 • 144 citations

FGF and EGF are mitogens for immortalized neural progenitors

1994 • 143 citations

CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomized cholinergic neurons after transplantation into the septum

1995 • 143 citations

Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons

1999 • 142 citations

The TINS Lecture

1999 • 142 citations

Somatic Cell Nuclear Transfer in Humans: Pronuclear and Early Embryonic Development

2001 • 142 citations

Differential regulation of telomerase activity and TERT expression during brain development in mice

2001 • 141 citations

Generation of DOPA-Producing Astrocytes by Retroviral Transduction of the Human Tyrosine Hydroxylase Gene:In VitroCharacterization andin VivoEffects in the Rat Parkinson Model

1996 • 140 citations

Neural-Targeted Gene Therapy for Rodent and Primate Hemiparkinsonism

1994 • 139 citations

Adult neurogenesis: From canaries to the clinic

1998 • 139 citations

Neurogenesis in Embryos and in Adult Neural Stem Cells

2002 • 138 citations

Immature Neurons From CNS Stem Cells Proliferate in Response to Platelet-Derived Growth Factor

2001 • 138 citations

Myelination Following Transplantation of EGF-Responsive Neural Stem Cells into a Myelin-Deficient Environment

1997 • 137 citations

Intraspinal Delivery of Neurotrophin-3 Using Neural Stem Cells Genetically Modified by Recombinant Retrovirus

1999 • 136 citations

Increased survival of rat EGF-generated CNS precursor cells using B27 supplemented medium

1995 • 136 citations

Survival, Neuronal Differentiation, and Fiber Outgrowth of Propagated Human Neural Precursor Grafts in an Animal Model of Huntington's Disease

2000 • 134 citations

Persistent Expression of Genes of the Enhancer of Split Complex Suppresses Neural Development in Drosophila

1996 • 130 citations

Putting Stem Cells to Work

1999 • 130 citations

Embryonic and Postnatal Injections of Bromodeoxyuridine Produce Age-Dependent Morphological and Behavioral Abnormalities

1999 • 129 citations

Incorporation and Glial Differentiation of Mouse EGF-Responsive Neural Progenitor Cells after Transplantation into the Embryonic Rat Brain

1998 • 129 citations

Transplantation of a Polymer-Encapsulated Cell Line Genetically Engineered to Release NGF

1993 • 129 citations

Neuroprotective and behavioral efficacy of nerve growth factor—transfected hippocampal progenitor cell transplants after experimental traumatic brain injury

2001 • 127 citations

Embryonic Precursor Cells That Express Trk Receptors: Induction of Different Cell Fates by NGF, BDNF, NT-3, and CNTF

1997 • 127 citations

Generation of Tyrosine Hydroxylase-Producing Neurons from Precursors of the Embryonic and Adult Forebrain

1999 • 125 citations

Neural Transplantation in Animal Models of Dementia

1990 • 124 citations

Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines

1992 • 122 citations

Cerebral white matter contains PDGF-responsive precursors to O2A cells

1990 • 121 citations

Inducible gene expression in mammalian cells and transgenic mice

1997 • 121 citations

Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors

2000 • 120 citations

Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.

1996 • 117 citations

The role of Sonic hedgehog in neural tube patterning

2000 • 113 citations

A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system

1995 • 112 citations

Isolation and Intracerebral Grafting of Nontransformed Multipotential Embryonic Human CNS Stem Cells

1999 • 110 citations

Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons

1995 • 110 citations

Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain. A light and electron microscopical immunocytochemical study

1991 • 105 citations

Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of Huntington's disease

1997 • 105 citations

Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers

1994 • 105 citations

A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors

1999 • 105 citations

Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord

1999 • 104 citations

Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro

1995 • 104 citations

Neuroepithelial progenitor cells explanted from human fetal brain proliferate and differentiatein vitro

1995 • 103 citations

Analysis of neural stem cells by flow cytometry: cellular differentiation modifies patterns of MHC expression

2001 • 100 citations

Heparin, but Not Other Proteoglycans Potentiates the Mitogenic Effects of FGF-2 on Mesencephalic Precursor Cells

1998 • 98 citations

Regulation of Neuronal Differentiation in Human CNS Stem Cell Progeny by Leukemia Inhibitory Factor

2000 • 98 citations

In vitro propagation and inducible differentiation of multipotential progenitor cells from human fetal brain

1997 • 97 citations

Notch signaling in the nervous system. Pieces still missing from the puzzle

2000 • 97 citations

Neural progenitors and stem cells: mechanisms of progenitor heterogeneity

1998 • 96 citations

Isolated rat cortical progenitor cells are maintained in division in vitro by membrane-associated factors

1994 • 95 citations

Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat

1996 • 92 citations

Correlation of Toxicity and Pharmacokinetic Properties of a Phosphorothioate Oligonucleotide Designed to Inhibit ICAM-1

1999 • 89 citations

Get to know your stem cells

2000 • 87 citations

Emergence of oligodendrocytes from human neural spheres

1997 • 87 citations

Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720

1996 • 87 citations

Indefinite survival of neural xenografts induced with anti-CD4 monoclonal antibodies

1996 • 86 citations

NeuroD and Neurogenesis

1997 • 84 citations

Telomerase is Not an Epidermal Stem Cell Marker and is Downregulated by Calcium

1998 • 81 citations

Chapter 21 Restoration of function by neural transplantation in the ischemic brain

2000 • 78 citations

Tracing human oligodendroglial development in vitro

2000 • 78 citations

Stem Cell Plasticity in Mammals and Transdetermination in Drosophila : Common Themes?

2000 • 77 citations

Genetic and epigenetic control of midbrain dopaminergic neuron development.

2000 • 75 citations

Microarrays in brain research: the good, the bad and the ugly

2001 • 75 citations

A Role for Complement in the Rejection of Porcine Ventral Mesencephalic Xenografts in a Rat Model of Parkinson's Disease

2000 • 74 citations

Isolation and transplantation of multipotential populations of epidermal growth factor-responsive, neural progenitor cells from the canine brain

1997 • 74 citations

Identification of Two Distinct Types of Multipotent Neural Precursors That Appear Sequentially during CNS Development

2001 • 73 citations

Cerebral implantation in movement disorders: State of the art

1999 • 72 citations

Neural stem cells – a versatile tool for cell replacement and gene therapy in the central nervous system

1999 • 71 citations

The morphological development of neurons derived from EGF‐ and FGF‐2‐driven human CNS precursors depends on their site of integration in the neonatal rat brain

2000 • 69 citations

Update on fetal transplantation: the Swedish experience.

1998 • 68 citations

Proliferation, cell death, and neuronal differentiation in transplanted human embryonal carcinoma (NTera2) cells depend on the graft site in nude and severe combined immunodeficient mice.

1995 • 68 citations

Fibroblast growth factor 2 up regulates telomerase activity in neural precursor cells

2000 • 65 citations

Extensive migration and target innervation by striatal precursors after grafting into the neonatal striatum

1997 • 65 citations

Roles of cell-autonomous mechanisms for differential expression of regionspecific transcription factors in neuroepithelial cells

1996 • 63 citations

The First Human Cloned Embryo

2002 • 61 citations

Conditionally immortalized neural progenitor cell lines integrate and differentiate after grafting to the adult rat striatum. A combined autoradiographic and electron microscopic study

1996 • 61 citations

DISCORDANT NEURAL TISSUE XENOGRAFTS SURVIVE LONGER IN IMMUNOGLOBULIN DEFICIENT MICE1

1999 • 58 citations

Expression pattern of PAX3 and PAX6 genes during human embryogenesis.

1999 • 58 citations

Embryonic stem cells: Proliferation and differentiation

1990 • 57 citations

Origins, functions, and potential of adult neural stem cells

1999 • 52 citations

The Business of Stem Cells

2000 • 50 citations

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease

1997 • 49 citations

A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation

1999 • 48 citations

Immortalization of neural cells via oncogene transduction

1988 • 45 citations

Human neural graft function in rats treated with anti-interleukin II receptor antibody

1990 • 43 citations

Molecular markers in CNS stem cell research: hitting a moving target

2001 • 43 citations

Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator

1994 • 42 citations

Effects of a novel differentiation factor on the development of catecholamine traits in noncatecholamine neurons from various regions of the rat brain: studies in tissue culture

1991 • 41 citations

Long-Term Survival of Transplanted Basal Forebrain Cells Followingin VitroPropagation with Fibroblast Growth Factor-2

1996 • 41 citations

Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain

2000 • 41 citations

Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?

2000 • 41 citations

Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential

2000 • 40 citations

Ex Vivo and In Vitro Studies of Transgene Expression in Rat Astrocytes Transduced with Lentiviral Vectors

2002 • 40 citations

Prevention of mouse-rat brain xenograft rejection by a combination therapy of cyclosporin A, prednisolone and azathioprine

1995 • 39 citations

Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2

1998 • 38 citations

Mechanisms of Progenitor Maturation Are Conserved in the Striatum and Cortex

2000 • 38 citations

Progress in Direct Striatal Delivery of l-Dopa via Gene Therapy for Treatment of Parkinson's Disease Using Recombinant Adeno-Associated Viral Vectors

1999 • 38 citations

Anomalous neural differentiation induced by 5‐bromo‐2′‐deoxyuridine during organogenesis in the rat

1987 • 36 citations

Transcription factors in early development of the central nervous system

1996 • 33 citations

Activin co-operates with fibroblast growth factor 2 to regulate tyrosine hydroxylase expression in the basal forebrain ventricular zone progenitors

1998 • 30 citations

Sonic Hedgehog Facilitates Dopamine Differentiation in the Presence of a Mesencephalic Glial Cell Line

2001 • 28 citations

Regulation and function of FGF8 in patterning of midbrain and anterior hindbrain

2000 • 26 citations

5-Azacytidine and BDNF Enhance the Maturation of Neurons Derived from EGF-Generated Neural Stem Cells

1997 • 23 citations

Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro

1999 • 22 citations

The importance of cell contact for the proliferation of neuroblasts in culture and its stimulation by meningeal extract

1982 • 19 citations

Nervous system modification by transplants and gene transfer

1994 • 19 citations

Epigenetic factors and midbrain dopaminergic neurone development

1996 • 17 citations

Non-virally mediated gene transfer into human central nervous system precursor cells

1996 • 14 citations

Notch signalling: You make me feel so glial

2000 • 11 citations

Chapter 25 Class I and II MHC expression and its implications for regeneration in the nervous system

1994 • 10 citations

Comparative stem cell biology.

1997 • 7 citations

Analysis of Cell Lineage in the Rat Cerebral Cortex^a

1991 • 4 citations

GIEMSA PREPARATION FOR STAINING BLOOD FILMS

1937 • 4 citations