Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1998 • 1,518 citations

Promotion of Trophoblast Stem Cell Proliferation by FGF4

1998 • 1,340 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

Expression pattern of the mouse T gene and its role in mesoderm formation

1990 • 854 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

New type of POU domain in germ line-specific protein Oct-4

1990 • 753 citations

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1990 • 745 citations

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.

1993 • 708 citations

Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

1994 • 623 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

The origin and efficient derivation of embryonic stem cells in the mouse

1997 • 533 citations

Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation

1998 • 488 citations

Expression of Cdx‐2 in the mouse embryo and placenta: Possible role in patterning of the extra‐embryonic membranes

1995 • 407 citations

The Gene for the Embryonic Stem Cell Coactivator UTF1 Carries a Regulatory Element Which Selectively Interacts with a Complex Composed of Oct-3/4 and Sox-2

1999 • 373 citations

Synergistic Activation of the Fibroblast Growth Factor 4 Enhancer by Sox2 and Oct-3 Depends on Protein-Protein Interactions Facilitated by a Specific Spatial Arrangement of Factor Binding Sites

1997 • 372 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2

1998 • 313 citations

Expression of the Novel Basic Helix-Loop-Helix Gene eHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

1995 • 248 citations

Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site

1998 • 234 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells

1999 • 189 citations

A nexus between Oct-4 and E1 A: Implications for gene regulation in embryonic stem cells

1991 • 188 citations

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway

1998 • 126 citations

Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.

1995 • 80 citations

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.

1993 • 74 citations

Identification of putative downstream genes of Oct‐3, a pluripotent cell‐specific transcription factor

1996 • 56 citations