Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

A theory of marginotomy

1973 • 1,770 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1987 • 1,127 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

1989 • 809 citations

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 • 693 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

1990 • 632 citations

STRUCTURE AND FUNCTION OF TELOMERES

1989 • 604 citations

Sugar and Disease

1972 • 532 citations

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

1989 • 481 citations

Human telomeres contain at least three types of G–rich repeat distributed non-randomly

1989 • 374 citations

Ethidium fluorescence assays. Part 1. Physicochemical studies

1979 • 348 citations

Growth of normal human mammary cells in culture

1980 • 316 citations

Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal

1985 • 295 citations

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

1989 • 252 citations

Structure and Variability of Human Chromosome Ends

1990 • 229 citations

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

1988 • 196 citations

Detection of the catalytic activities of DNA polymerases and their associated exonucleases following SDS-polyacrylamide gel electrophoresis

1981 • 193 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

Telomeric repeat from T. thermophila cross hybridizes with human telomeres

1988 • 190 citations

Telomere terminal transferase activity in the hypotrichous ciliateOxytricha novaand a model for replication of the ends of linear DNA molecules

1988 • 171 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Cloning of human telomeres by complementation in yeast

1989 • 162 citations

Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

1991 • 156 citations

In vitro transformation of human epithelial cells

1986 • 148 citations

Molecular cloning of human telomeres in yeast

1989 • 147 citations

Relative Difficulties in Transforming Human and Animal Cells in Vitro

1983 • 136 citations

Human cell transformation by simian virus 40—A review

1981 • 135 citations

Reversible Cellular Senescence: Implications for Immortalization of Normal Human Diploid Fibroblasts

1989 • 129 citations

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.

1989 • 118 citations

DNA polymerase III from Saccharomyces cerevisiae. I. Purification and characterization.

1988 • 116 citations

Non‐random chromosomal aberrations in SV₄₀‐transformed human cells

1963 • 115 citations

Telomeric association of chromosomes in B-cell lymphoid leukemia

1984 • 104 citations

Growth of 293 Cells in Suspension Culture

1987 • 103 citations

Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent.

1989 • 103 citations

Early Chromosomal Changes in SV<sub>40</sub>-Infected Human Fibroblast Cultures

1964 • 95 citations

THE SEQUENCE OF CHROMOSOME ABERRATIONS DURING SV 40 TRANSFORMATION OF A HUMAN DIPLOID CELL STRAIN1

2009 • 72 citations

SV40‐transformed human fibroblasts: Evidence for cellular aging in precrisis cells

1985 • 66 citations

Telomeric association: another characteristic of cancer chromosomes?

1988 • 59 citations

Cytogenetic instability with balanced chromosome changes in an SV40 transformed human uroepithelial cell line.

1988 • 59 citations

Telomere Terminal Transferase Activity from Euplotes crassus Adds Large Numbers of TTTTGGGG Repeats onto Telomeric Primers

1989 • 29 citations

Notes: Growth of Immortal Simian Virus 40 tsA-Transformed Human Fibroblasts Is Temperature Dependent

1989 • 26 citations

Chromosome instability in cell lineages of amniocyte clones morphologically transformed by Simian virus 40

1987 • 19 citations