Replicative Senescence: An Old Lives' Tale?

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

ON THE PERMANENT LIFE OF TISSUES OUTSIDE OF THE ORGANISM

1912 • 473 citations

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1981 • 348 citations

Telomeres and telomerase in aging and cancer

1995 • 328 citations

Expression of Heat Shock Protein 70 is Altered by Age and Diet at the Level of Transcription

1993 • 284 citations

Replicative senescence of human fibroblast-like cells in culture

1993 • 270 citations

Expression of heat shock protein 70 is altered by age and diet at the level of transcription.

1993 • 237 citations

Cellular Senescence revisited: a review

1987 • 171 citations

Towards an understanding of the malignant transformation of diploid human fibroblasts

1988 • 121 citations

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1995 • 121 citations

Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1.

1994 • 105 citations

Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts.

1990 • 99 citations

The genetics of aging in the yeastSaccharomyces cerevisiae

1993 • 98 citations

Regulation of c‐fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors

1995 • 78 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

Ponce d'elegans: Genetic Quest for the Fountain of Youth

1996 • 59 citations

Integrated Mapping Analysis of the Werner Syndrome Region of Chromosome 8

1994 • 26 citations