Neural induction

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling

1999 • 710 citations

Zebrafish organizer development and germ-layer formation require nodal-related signals

1998 • 657 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Multiple defects and perinatal death in mice deficient in follistatin

1995 • 586 citations

A Role for the Roof Plate and Its Resident TGFβ-Related Proteins in Neuronal Patterning in the Dorsal Spinal Cord

1997 • 575 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

The organizer factors Chordin and Noggin are required for mouse forebrain development

2000 • 528 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

1996 • 516 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Fate mapping and cell lineage analysis of Hensen’s node in the chick embryo

1991 • 433 citations

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

1998 • 424 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

1997 • 404 citations

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

1997 • 398 citations

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

1997 • 382 citations

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

1999 • 372 citations

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

1998 • 350 citations

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

1999 • 338 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo

2000 • 326 citations

dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

1996 • 325 citations

Fates and migratory routes of primitive streak cells in the chick embryo

1996 • 272 citations

Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity

1999 • 236 citations

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

1995 • 225 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation

1998 • 222 citations

Embryonic Patterning: To BMP or Not to BMP, That Is the Question

1997 • 221 citations

Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation

1989 • 218 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo

2000 • 202 citations

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo

1999 • 193 citations

Zebrafish nodal-related 2Encodes an Early Mesendodermal Inducer Signaling from the Extraembryonic Yolk Syncytial Layer

1998 • 169 citations

Neural Induction

1999 • 165 citations

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.

1995 • 161 citations

Molecular Interactions Continuously Define the Organizer during the Cell Movements of Gastrulation

1999 • 160 citations

Microtubule-mediated transport of organelles and localization of β-catenin to the future dorsal side of Xenopus eggs

1997 • 159 citations

Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3

1997 • 158 citations

The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

1994 • 145 citations

Region-Specific Neural Induction of an engrailed Protein by Anterior Notochord in Xenopus

1990 • 145 citations

Siamois is required for formation of Spemann’s organizer

1997 • 144 citations

Specification of the Zebrafish Nervous System by Nonaxial Signals

1997 • 137 citations

Vertebrate Neural Induction: Inducers, Inhibitors, and a New Synthesis

1997 • 131 citations

Restoration of the organizer after radical ablation of Hensen’s node and the anterior primitive streak in the chick embryo

1996 • 112 citations

Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions

1996 • 112 citations

Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish

2000 • 109 citations

A role for Siamois in Spemann organizer formation

1997 • 108 citations

Neural Induction and Patterning in the Mouse in the Absence of the Node and Its Derivatives

1999 • 107 citations

The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis

1990 • 106 citations

The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways

2000 • 105 citations

The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula

1990 • 102 citations

Neural induction: a bird's eye view

1999 • 97 citations

Neural induction in Xenopus

1994 • 97 citations

XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue

1998 • 92 citations

Spatial aspects of neural induction in Xenopus laevis

1989 • 91 citations

Identifying the Missing Links

1998 • 88 citations

bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish

2000 • 85 citations

Impact of Node Ablation on the Morphogenesis of the Body Axis and the Lateral Asymmetry of the Mouse Embryo during Early Organogenesis

1999 • 83 citations

The nieuwkoid/dharma Homeobox Gene Is Essential for bmp2b Repression in the Zebrafish Pregastrula

1999 • 82 citations

Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs

1993 • 77 citations

Mesoderm patterning and somite formation during node regression: differential effects of chordin and noggin

1999 • 75 citations

Maternal and Zygotic Activity of the Zebrafish ogon Locus Antagonizes BMP Signaling

1999 • 69 citations

Anti-Neural-Inhibition: A Conserved Mechanism for Neural Induction

1997 • 68 citations

The Mouse Cer1 (Cerberus related or homologue) Gene Is Not Required for Anterior Pattern Formation

1999 • 62 citations

Homeogenetic neural induction in xenopus

1991 • 42 citations

Mesodermal patterning during avian gastrulation and neurulation: Experimental induction of notochord from non‐notochordal precursor cells

1995 • 35 citations