Genetic and epigenetic control of midbrain dopaminergic neuron development.

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Dopamine Receptors: From Structure to Function

1998 • 3,489 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Stem Cells in the Central Nervous System

1997 • 1,483 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Efferent connections of the substantia nigra and ventral tegmental area in the rat

1979 • 1,278 citations

Dopamine Neuron Agenesis in Nurr1-Deficient Mice

1997 • 1,075 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

Dopamine neurons and their role in reward mechanisms

1997 • 757 citations

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

1998 • 725 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

1998 • 539 citations

The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat

1988 • 499 citations

Widespread origin of the primate mesofrontal dopamine system

1998 • 463 citations

Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease

1997 • 449 citations

Stem cells in the adult mammalian central nervous system

1999 • 439 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

1999 • 373 citations

Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain

1999 • 361 citations

Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

1997 • 358 citations

Glial heterogeneity may define the three-dimensional shape of mouse mesencephalic dopaminergic neurones

1984 • 326 citations

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

1998 • 298 citations

Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene

1998 • 291 citations

Effect of striatal cells on in vitro maturation of mesencephalic dopaminergic neurones grown in serum-free conditions

1980 • 281 citations

Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder

1998 • 275 citations

In vitro maturation of mesencephalic dopaminergic neurons from mouse embryos is enhanced in presence of their striatal target cells.

1979 • 273 citations

The dopaminergic mesencephalic projections to the hippocampal formation in the rat

1997 • 273 citations

High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.

1994 • 271 citations

Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's Disease

1997 • 270 citations

Loss of autoreceptor functions in mice lacking the dopamine transporter

1999 • 253 citations

Water-stable fluorophores, produced by reaction with aldehyde solutions, for the histochemical localization of catechol- and indolethylamines

1977 • 205 citations

Postmitotic, postmigrational expression of tyrosine hydroxylase in olfactory bulb dopaminergic neurons

1988 • 164 citations

Neurobiology of schizophrenia

1997 • 157 citations

The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism

1990 • 145 citations

Neurotransmitter transporters: three distinct gene families

1993 • 141 citations

The organization of the thalamic, nigral and raphe cells projecting to the medial vs lateral caudate-putamen in rat. A fluorescent retrograde double labeling study

1979 • 141 citations

Midbrain dopaminergic neurons in the mouse: Computer-assisted mapping

1996 • 140 citations

Pharmacology and regulation of the neuronal dopamine transporter

1997 • 139 citations

Specification of Distinct Dopaminergic Neural Pathways: Roles of the Eph Family Receptor EphB1 and Ligand Ephrin-B2

1999 • 132 citations

Apoptosis in substantia nigra following developmental striatal excitotoxic injury.

1994 • 129 citations

Development of dopaminergic neurons in the human substantia nigra

1991 • 121 citations

Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro

1995 • 104 citations

Long-term development of mesencephalic dopaminergic neurons of mouse embryos in dissociated primary cultures: Morphological and histochemical characteristics

1982 • 101 citations

A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture

1992 • 82 citations

Early appearance of tyrosine hydroxylase immunoreactive cells in the mesencephalon of mouse embryos

1990 • 72 citations

Multiplex semi-quantitative reverse transcriptase–polymerase chain reaction of low abundance neuronal mRNAs

1999 • 71 citations

Growth cone localization of neural cell adhesion molecule on central nervous system neurons in vitro.

1986 • 58 citations

Release of dopamine from dissociated mesencephalic dopaminergic neurons in primary cultures in absence or presence of striatal target cells

1980 • 56 citations

1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Metabolism and l‐Methyl‐4‐Phenylpyridinium Uptake in Dissociated Cell Cultures from the Embryonic Mesencephalon

1988 • 55 citations

Dopamine Synthesis Precedes Dopamine Uptake in Embryonic Rat Mesencephalic Neurons

1991 • 54 citations

Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures

1997 • 51 citations

Target and neurotransmitter specificity of fetal central nervous system transplants: importance for functional reinnervation

1994 • 50 citations

Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons

1991 • 44 citations

Sprouting of Dopaminergic Axons after Striatal Injury: Confirmation by Markers Not Dependent on Dopamine Metabolism

1999 • 42 citations

Retinoids: from hindbrain patterning to Parkinson disease

1997 • 41 citations

Target cells modulate dopamine transporter gene expression during brain development

1994 • 39 citations

Involvement of Activation of Dopamineraic Neuronal System in Learning and Memory Deficits Associated with Experimental Mild Traumatic Brain Injury

1997 • 37 citations

Dopamine transporter gene expression in rat mesencephalic dopaminergic neurons is increased by direct interaction with target striatal cells in vitro

1996 • 31 citations

Early ontogeny of catecholaminergic cell lineage in brain and peripheral neurons monitored by tyrosine hydroxylase-lacZ transgene

1996 • 30 citations

Epigenetic cues in midbrain dopaminergic neuron development

2000 • 25 citations

Dopaminergic neurons from embryonic mouse mesencephalon are enriched in culture through immunoreaction with monoclonal antibody to neural specific protein 4 and flow cytometry.

1987 • 24 citations

Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease.

1999 • 24 citations

Dopaminergic neurons grown in three-dimensional reaggregate culture for periods of up to one year

1993 • 23 citations

Retinoic Acids Differentially Regulate NOR-1 and Its Closely Related Orphan Nuclear Receptor Genes in Breast Cancer Cell Line MCF-7

1997 • 20 citations

Embryonic dopaminergic neuron transplants in MPTP lesioned mouse striatum

1992 • 10 citations

Growth factor actions on developing midbrain dopaminergic neurons

1999 • 5 citations