Selective oestrogen receptor modulation

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Tamoxifen for early breast cancer: an overview of the randomised trials

1998 • 4,082 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women

1997 • 1,641 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.1

1896 • 1,240 citations

Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer

1992 • 1,139 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

A two-step mechanism for the interaction of estradiol with rat uterus.

1968 • 1,013 citations

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

1976 • 993 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

The nuclear receptor ligand-binding domain: structure and function

1998 • 829 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

1999 • 788 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women

1998 • 702 citations

A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474

1971 • 692 citations

Estrogen Receptors α and β Form Heterodimers on DNA

1997 • 681 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

1994 • 614 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors

1998 • 580 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

Hormone Receptors: Studies on the Interaction of Estrogen with the Uterus

1968 • 537 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

1999 • 460 citations

A NEW DERIVATIVE OF TRIPHENYLETHYLENE: EFFECT ON IMPLANTATION AND MODE OF ACTION IN RATS

1967 • 456 citations

Approaches to prevention of epithelial cancer during the preneoplastic period.

1976 • 444 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene

1996 • 432 citations

The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

1998 • 421 citations

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

1988 • 420 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Nuclear receptor coactivators and corepressors

1996 • 414 citations

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

1996 • 410 citations

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

1994 • 402 citations

MCF-7: the first hormone-responsive breast cancer cell line.

1997 • 401 citations

Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex

1996 • 399 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women

1991 • 380 citations

Interaction of proteins with transcriptionally active estrogen receptors.

1994 • 379 citations

Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels

1973 • 373 citations

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.

1987 • 355 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1995 • 351 citations

Ligand-independent activation of steroid hormone receptors

1998 • 349 citations

Effects of anti-estrogens on bone in castrated and intact female rats

1987 • 329 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor

1997 • 326 citations

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β*

1999 • 312 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

1997 • 301 citations

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

1998 • 301 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

1994 • 293 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones

1996 • 285 citations

Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient.

1991 • 267 citations

Tamoxifen, Raloxifene, and the Prevention of Breast Cancer*

1999 • 259 citations

Randomized Trial of Two Versus Five Years of Adjuvant Tamoxifen for Postmenopausal Early Stage Breast Cancer

1996 • 258 citations

Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

1999 • 244 citations

A NON-STEROIDAL ESTROGEN ANTAGONIST l-(p-2-DIETHYLAMINOETHOXYPHENYLH-PHENYL-2-p-METHOXYPHENYL ETHANOL

1958 • 233 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists.

1995 • 230 citations

A receptor molecule for estrogens: studies using a cell-free system.

1967 • 229 citations

Different Regions in Activation Function-1 of the Human Estrogen Receptor Required for Antiestrogen- and Estradiol-dependent Transcription Activation

1996 • 214 citations

STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTI-OESTROGENS WITH REGARD TO INTERACTION WITH 17β-OESTRADIOL IN THE MOUSE UTERUS AND VAGINA

1971 • 211 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

1995 • 206 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I

1993 • 206 citations

Mouse Estrogen Receptor Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor

1997 • 203 citations

Hormonal Pathogenesis of Adenocarcinoma of the Breast

1936 • 195 citations

Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor

1975 • 186 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

Transcriptional Activators Differ in Their Responses to Overexpression of TATA-Box-Binding Protein

1995 • 163 citations

?Studies on the estrogen receptor in breast cancer? ? 20 years as a target for the treatment and prevention of cancer

1995 • 155 citations

Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models

1998 • 155 citations

(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen

1997 • 154 citations

Effects of raloxifene hydrochloride on the endometrium of postmenopausal women

1997 • 149 citations

A realistic clinical perspective of tamoxifen and endometrial carcinogenesis

1996 • 145 citations

Remodeling the estrogen receptor model

1984 • 142 citations

Suppression of Mouse Mammary Tumorigenesis by Long-Term Tamoxifen Therapy

1991 • 141 citations

Estrogen receptor-beta messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins.

1999 • 138 citations

Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex

1999 • 138 citations

RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites

1996 • 132 citations

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro.

1983 • 131 citations

The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole

1988 • 130 citations

LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo.

1998 • 129 citations

Tamoxifen, Raloxifene, and the Prevention of Breast Cancer

1999 • 128 citations

Dissection of the Molecular Mechanism of Action of GW5638, a Novel Estrogen Receptor Ligand, Provides Insights into the Role of Estrogen Receptor in Bone*

1997 • 122 citations

The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.

1998 • 122 citations

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.

1995 • 119 citations

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats.

1995 • 117 citations

A Molecular Theory of Drug Action Based on Induced Conformational Perturbations of Receptors¹

1964 • 112 citations

Estrogen Receptor β Activates the Human Retinoic Acid Receptorα -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

1999 • 106 citations

Mechanisms of antihormone action

1992 • 104 citations

Selective Estrogen Receptor Modulators

1999 • 104 citations

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor

1997 • 104 citations

Estrogen/Antiestrogen Action and Breast Cancer Therapy

1986 • 102 citations

Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications

1983 • 98 citations

Exploring the role of sex steroids through studies of receptor deficient mice

1998 • 97 citations

The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists

1995 • 96 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

1994 • 92 citations

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor- or Estrogen Receptor-

1999 • 91 citations

Droloxifene, a new antiestrogen: Its role in metastatic breast cancer

1994 • 82 citations

Different TBP-associated factors are required for mediating the stimulation of transcriptionin vitroby the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor

1993 • 81 citations

Designer Estrogens

1998 • 80 citations

Differences between estrogen- and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor.

1984 • 79 citations

Non-Steroidal Antioestrogens

1983 • 72 citations

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo

1995 • 70 citations

The Use of Estrogen Antagonists in Hormone Receptor Studies

1972 • 69 citations

The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor

1998 • 65 citations

The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor.

1999 • 65 citations

OOPHORECTOMY IN CANCER OF THE BREAST

1902 • 62 citations

Anti-oestrogenic and anti-tumour properties of prolonged tamoxifen therapy in C3H/OUJ mice

1990 • 49 citations

Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models

1998 • 47 citations

Estrogen Receptor Activates the Human Retinoic Acid Receptor -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

1999 • 40 citations

Implications of tamoxifen metabolism in the athymic mouse for the study of antitumor effects upon human breast cancer xenografts

1989 • 39 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells

1994 • 39 citations

Droloxifene, a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats

1995 • 37 citations

Dissection of the Molecular Mechanism of Action of GW5638, a Novel Estrogen Receptor Ligand, Provides Insights into the Role of Estrogen Receptor in Bone

1997 • 37 citations

Paul Ehrlich, scientist for life

1984 • 37 citations

Paul Ehrlich: Scientist for life

1985 • 36 citations

Aminoglutethimide treatment in advanced breast cancer: An efficient therapy as a late endocrine alternative in a sequential therapeutic approach

1983 • 27 citations

Estrogen receptor as a target for the prevention of breast cancer

1999 • 18 citations

Yearbook of Pathology and Clinical Pathology

1961 • 4 citations