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1980 • 212 citations

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1983 • 177 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys1

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1974 • 175 citations

Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic Acid

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A realistic clinical perspective of tamoxifen and endometrial carcinogenesis

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1984 • 142 citations

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Physical Activity and Risk of Breast Cancer in the Framingham Heart Study

1994 • 141 citations

Suppression of Mouse Mammary Tumorigenesis by Long-Term Tamoxifen Therapy

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1992 • 140 citations

PRACTICAL GUIDE FOR ESTIMATING RISK FOR FAMILIAL BREAST CANCER

1983 • 139 citations

Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice

1980 • 137 citations

Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance.

1996 • 137 citations

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Raloxifene Inhibits Aortic Accumulation of Cholesterol in Ovariectomized, Cholesterol-Fed Rabbits

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1976 • 134 citations

Serum lipoproteins and proteins after breast cancer surgery and effects of tamoxifen

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An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro.

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1987 • 131 citations

Lack of genotoxicity of tamoxifen in human endometrium.

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1990 • 127 citations

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Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women

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1989 • 125 citations

Antiestrogen basicity-activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogs of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (Tamoxifen, Nolvadex) having altered basicity

1982 • 123 citations

The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.

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1974 • 107 citations

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Dual-energy X-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats

1994 • 104 citations

Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor

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Oral Contraceptives in Relation to Breast Cancer

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1995 • 100 citations

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Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: Problems and potential for future clinical applications

1983 • 98 citations

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1975 • 96 citations

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1976 • 96 citations

Gynecologic effects of tamoxifen and the association with endometrial carcinoma

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1981 • 95 citations

Reproductive Endocrine and Endometrial Effects of Raloxifene Hydrochloride, a Selective Estrogen Receptor Modulator, in Women with Regular Menstrual Cycles1

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1997 • 92 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

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1953 • 92 citations

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1965 • 89 citations

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1979 • 89 citations

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Antiestrogenic properties of keoxifene,trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells

1989 • 87 citations

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A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog.

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Inhibition of the Uterotropic Activity of Estrogens and Antiestrogens by the Short Acting Antiestrogen LY117018*

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Binding of [3h]tamoxifen in rat uterine cytosols: A comparison of swinging bucket and vertical tube rotor sucrose density gradient analysis

1977 • 66 citations

The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor

1998 • 65 citations

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A case—control study of breast cancer and alcohol consumption habits

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1979 • 50 citations

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Combined effect of family history and reproductive factors on breast cancer risk

1989 • 45 citations

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1989 • 39 citations

Differential antiestrogen action in the immature rat uterus: A comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor

1983 • 33 citations

Genomic changes in endometrial polyps associated with tamoxifen show no evidence for its action as an external carcinogen.

1998 • 31 citations

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1951 • 31 citations

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1996 • 31 citations

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1938 • 30 citations

A model to describe how a point mutation of the estrogen receptor alters the structure-function relationship of antiestrogens

1993 • 30 citations

Effect of an estrogen antagonist (tamoxifen) on the initiation and progression of γ-irradiation-induced mammary tumors in female Sprague-Dawley rats

1981 • 29 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys

1998 • 28 citations

Aminoglutethimide treatment in advanced breast cancer: An efficient therapy as a late endocrine alternative in a sequential therapeutic approach

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1976 • 22 citations

Review¶Hormone action and chromatin remodelling

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Effect of tamoxifen feeding on metabolic activation of tamoxifen by the liver of the Rhesus monkey: Does liver accumulation of inhibitory metabolities protect from tamoxifen-dependent genotoxicity and cancer?

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A New Synthetic Œstrogen with Prolonged Action when Given Orally

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On Some of the Rarer Forms of Rectal Fistulae

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