The nuclear receptor ligand-binding domain: structure and function

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Nuclear receptor coactivators

1997 • 720 citations

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

1996 • 627 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2

1997 • 585 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

1998 • 516 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Ligand binding was acquired during evolution of nuclear receptors

1997 • 407 citations

TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1

1997 • 380 citations

Transcription factors 3: nuclear receptors.

1995 • 327 citations

Isoforms of steroid receptor co-activator 1differ in their ability to potentiate transcription by the oestrogen receptor

1998 • 321 citations

Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

1997 • 307 citations

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

1996 • 231 citations

AF-2 Activity and Recruitment of Steroid Receptor Coactivator 1 to the Estrogen Receptor Depend on a Lysine Residue Conserved in Nuclear Receptors

1997 • 214 citations

Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation

1997 • 149 citations

Conformational adaptation of agonists to the human nuclear receptor RARγ

1998 • 140 citations

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

1997 • 135 citations

Intracellular receptors use a common mechanism to interpret signaling information at response elements.

1996 • 125 citations

Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

1997 • 121 citations

Different positioning of the ligand-binding domain helix 12and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists

1998 • 109 citations

Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities

1998 • 93 citations

Ligand- and DNA-induced dissociation of RXR tetramers

1998 • 71 citations

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein

1996 • 63 citations

Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities

1997 • 22 citations