Mechanisms of antihormone action

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Contragestion and Other Clinical Applications of RU 486, an Antiprogesterone at the Receptor

1989 • 495 citations

The human oestrogen receptor functions in yeast

1988 • 402 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

The Antiprogestin Steroid RU 486 and Human Fertility Control

1985 • 298 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells

1991 • 182 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Biology and mode of action of pure antioestrogens.

1988 • 149 citations

A Single Amino Acid That Determines the Sensitivity of Progesterone Receptors to RU486

1992 • 141 citations

Biology and mode of action of pure antioestrogens

1988 • 136 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

1991 • 84 citations