8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Textbook of Rheumatology

1985 • 1,671 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Bone and Mineral Research

1990 • 1,070 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Plasminogen activator inhibitors

1987 • 957 citations

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

1985 • 911 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES

1974 • 719 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Structure and Function of Collagen Types

1987 • 653 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Capillary endothelial cell cultures: phenotypic modulation by matrix components.

1983 • 611 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

1989 • 566 citations

Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

1986 • 533 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Studies on the role of plasminogen activator in ovulation. In vitro response of granulosa cells to gonadotropins, cyclic nucleotides, and prostaglandins.

1976 • 502 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny

1989 • 460 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.

1989 • 451 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator.

1982 • 415 citations

Proteases and biological control

1975 • 412 citations

Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis

1988 • 410 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Plasminogen Activator Release at the Neuronal Growth Cone

1981 • 388 citations

Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures

1977 • 387 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

1987 • 336 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

The role of proteinase in cellular invasiveness

1983 • 297 citations

Histology : cell and tissue biology

1983 • 296 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Plasminogen activator and collagenase production by cultured capillary endothelial cells

1982 • 279 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Purification and characterization of heparin-binding endothelial cell growth factors.

1986 • 263 citations

Identification of the Molecular Defect in a Family with Spondyloepiphyseal Dysplasia

1989 • 248 citations

Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.

1988 • 244 citations

Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations.

1988 • 238 citations

Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid.

1983 • 231 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Action of rat liver cathepsin L on collagen and other substrates.

1982 • 221 citations

Release of plasminogen activator and a calcium-dependent metalloprotease from cultured sympathetic and sensory neurons

1985 • 221 citations

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

1988 • 220 citations

Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

1985 • 220 citations

Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

1987 • 217 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.

1986 • 215 citations

Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members

1989 • 212 citations

Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

1987 • 209 citations

Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin.

1979 • 206 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

Formation of genetically mosaic mouse embryos, and early development of “lethal (t¹²/t¹²)–normal” mosaics

1964 • 205 citations

Expression of transforming growth factor β2 RNA during murine embryogenesis

1989 • 202 citations

Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase‐type plasminogen activator

1985 • 201 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

1985 • 199 citations

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

1984 • 192 citations

Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.

1981 • 188 citations

Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor

1987 • 188 citations

A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

1988 • 187 citations

Induction of collagenase secretion in human fibroblast cultures by growth promoting factors.

1985 • 186 citations

Current Advances in Skeletogenesis

1983 • 179 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Critical factors controlling angiogenesis: cell products, cell matrix, and growth factors.

1986 • 175 citations

Antisense RNA Directed Against the 3′ Noncoding Region Prevents Dormant mRNA Activation in Mouse Oocytes

1988 • 174 citations

The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.

1987 • 173 citations

Enhanced expression of TGF-β and c-fos mRNAs in the growth plates of developing human long bones

1988 • 173 citations

The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor

1983 • 172 citations

Cleavage of type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the amino-terminal portion of the smaller fragment released from both collagens

1976 • 171 citations

Human transforming growth factor-alpha stimulates bone resorption in vitro.

1985 • 169 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

Secreted forms of human neutrophil collagenase.

1986 • 167 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

1987 • 158 citations

Peripheral neurons and Schwann cells secrete plasminogen activator.

1984 • 158 citations

A specific inhibitor of vertebrate collagenase produced by human skin fibroblasts.

1979 • 157 citations

The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis

1977 • 156 citations

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts

1986 • 155 citations

Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development.

1988 • 154 citations

Proteolytic Enzymes in Cancer Invasion and Metastasis

1986 • 154 citations

Expression and function of cell surface extracellular matrix receptors in mouse blastocyst attachment and outgrowth.

1988 • 150 citations

Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator

1981 • 149 citations

Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator

1988 • 148 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

The major excreted protein of transformed fibroblasts is an activable acid-protease.

1986 • 147 citations

Amino acid requirements for attachment and outgrowth of the mouse blastocyst in vitro

1966 • 143 citations

Differential Expression of Transforming Growth Factor-α during Prenatal Development of the Mouse

1985 • 138 citations

Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells

1978 • 137 citations

Association of a plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells.

1987 • 135 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors

1987 • 121 citations

Cathepsins B1 and D. Action on human cartilage proteoglycans

1973 • 120 citations

The extracellular matrix of normal chick embryo fibroblasts: its effect on transformed chick fibroblasts and its proteolytic degradation by the transformants.

1985 • 114 citations

Transforming growth factor β alters plasminogen activator activity in human skin fibroblasts

1986 • 114 citations

Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA

1989 • 114 citations

Heparin/heparan sulfate is involved in attachment and spreading of mouse embryos in vitro

1987 • 112 citations

Laminin interacts with plasminogen and its tissue‐type activator

1984 • 112 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

Gene expression in mineralizing chick epiphyseal cartilage.

1988 • 109 citations

Localization of the expression of types I, III, and IV collagen, TGF-β1 and c-fos genes in developing human calvarial bones

1988 • 109 citations

Inhibition of human skin collagenase by human serum.

1970 • 109 citations

Degradation of extracellular matrix by mouse trophoblast outgrowths: a model for implantation

1983 • 107 citations

Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA.

1988 • 107 citations

Trophoblast‐decidual cell interactions and establishment of maternal blood circulation in the parietal yolk sac placenta of the rat

1987 • 106 citations

Plasminogen activation by single-chain urokinase in functional isolation. A kinetic study.

1987 • 103 citations

Isolation and sequence of a cDNA for human pro-(cathepsin L)

1988 • 98 citations

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

1989 • 97 citations

Increase in urokinase plasminogen activator mRNA synthesis in human carcinoma cells is a primary effect of the potent tumor promoter, phorbol myristate acetate.

1986 • 96 citations

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

1984 • 95 citations

Isolation of cDNA clones for basal lamina components: type IV procollagen

1983 • 93 citations

Affinity purification of active plasminogen activator inhibitor-1 (PAI-1) using immobilized anhydrourokinase

1989 • 91 citations

Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.

1985 • 89 citations

Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells

1988 • 88 citations

Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase

1987 • 86 citations

Normal epithelial branching morphogenesis in the absence of collagen I

1986 • 84 citations

Opposite and selective effects of epidermal growth factor and human platelet transforming growth factor-beta on the production of secreted proteins by murine 3T3 cells and human fibroblasts.

1986 • 84 citations

THE MORPHOLOGY OF BLASTOCYST IMPLANTATION

1974 • 78 citations

Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin.

1983 • 78 citations

Gonadotropin regulation of tissue-type and urokinase-type plasminogen activators in rat granulosa and theca-interstitial cells during the periovulatory period

1987 • 76 citations

Regulatory Proteolytic Enzymes and their Inhibitors

1978 • 75 citations

The predominant secreted protein of transformed murine fibroblasts carries the lysosomal mannose 6-phosphate recognition marker.

1982 • 72 citations

Mesosecrin: a secreted glycoprotein produced in abundance by human mesothelial, endothelial, and kidney epithelial cells in culture.

1987 • 72 citations

Specific induction of secreted proteins by transforming growth factor-beta and 12-O-tetradecanoylphorbol-13-acetate. Relationship with an inhibitor of plasminogen activator.

1987 • 72 citations

Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization.

1982 • 72 citations

Direct extraction and assay of bone tissue collagenase and its relation to parathyroid-hormone-induced bone resorption

1986 • 71 citations

Morphology and biochemistry of bone remodeling: possible control by vitamin D, parathyroid hormone, and other substances.

1988 • 71 citations

The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity

1986 • 66 citations

Two latent metalloproteases of human articular cartilage that digest proteoglycan.

1984 • 66 citations

Modulation of plasminogen activator in rodent mammary tumors by hormones and other effectors.

1983 • 57 citations

Detection of both type 1 and type 2 plasminogen activator inhibitors in human cells

1988 • 56 citations

Inhibition of one-chain and two-chain forms of human tissue-type plasminogen activator by the fast-acting inhibitor of plasminogen activator in vitro and in vivo.

1986 • 56 citations

Purification and characterization of an acid metalloproteinase from human articular cartilage.

1986 • 56 citations

Interaction of plasmin with endothelial cells

1984 • 54 citations

Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA.

1987 • 51 citations

Urokinase‐type and tissue‐type plasminogen activators have different distributions in cultured bovine capillary endothelial cells

1986 • 48 citations

Action of epidermal growth factor and retinoids on anchorage-dependent and -independent growth of nontransformed rat kidney cells.

1983 • 43 citations

Osteogenesis Imperfecta: The Molecular Basis of Clinical Heterogeneity^a

1988 • 36 citations

Estrogen-induced membrane alterations and growth associated with proteinase activity in endometrial cells.

1979 • 35 citations

N-linked glycoprotein biosynthesis in the developing mouse embryo

1986 • 35 citations

Antiangiogenesis as a Strategy for Antimetastasis

1988 • 34 citations

Studies on the mechanism of Ca²⁺ stimulation of plasminogen activator synthesis/release by swiss 3T3 cells

1979 • 13 citations

Partial purification and characterization of a neutral proteinase with collagen telopeptidase activity produced by human gingival fibroblasts

1987 • 12 citations

General Strategies for Isolating the Genes Encoding Type I Collagen and for Characterizing Mutations Which Produce Osteogenesis Imperfecta^a

1988 • 6 citations