Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.

1986 • 632 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Protein a from Staphylococcus aureus. Its isolation by affinity chromatography and its use as an immunosorbent for isolation of immunoglobulins

1972 • 607 citations

[α1(III)]3 Human Skin Collagen

1974 • 592 citations

Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.

1987 • 539 citations

Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.

1986 • 484 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Isolation and characterization of a chick cartilage collagen containing three identical chains

1971 • 395 citations

A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen

1979 • 350 citations

The Primary Structure of Collagen

1976 • 349 citations

Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.

1965 • 339 citations

Isolation of dermatan sulfate proteoglycans from mature bovine articular cartilages.

1985 • 315 citations

Light microscopic visualization of colloidal gold on resin-embedded tissue.

1983 • 298 citations

Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

1984 • 286 citations

Extraction, fractionation and characterization of proteoglycans from bovine tracheal cartilage

1972 • 275 citations

T Lymphocytes in Collagen II‐Induced Arthritis in Mice

1985 • 253 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever.

1985 • 192 citations

The degradation of articular collagen by neutrophil proteinases

1977 • 189 citations

Proteoglycans from bovine nasal cartilage. Properties of a soluble form of link protein.

1979 • 162 citations

Electron microscopic studies of the cartilage‐pannus junction in rheumatoid arthritis

1975 • 157 citations

The Mechanical Properties of Articular Cartilage

1980 • 149 citations

Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

1981 • 138 citations

The Use of a Chrome Alum-Gelatin (Subbing) Solution as a General Adhesive for Paraffin Sections

1971 • 119 citations

The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis

1987 • 110 citations

Localization of proteoglycan monomer and link protein in the matrix of bovine articular cartilage: An immunohistochemical study.

1980 • 108 citations

Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.

1975 • 89 citations

Cloning of a complementary dna for rabbit proactivator. a metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase

1987 • 86 citations

Conformation dependence of antigenic determinants on the collagen molecule.

1973 • 77 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage

1983 • 77 citations

Immunological Studies on Collagen

1976 • 71 citations

A growing family of collagens in articular cartilage: identification of 5 genetically distinct types.

1987 • 70 citations

Intracellular collagen fibers at the pannus‐cartilage junction in rheumatoid arthritis

1977 • 63 citations

Lymphocyte transformation to connective tissue antigens in adult and juvenile rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic lupus erythematosus, and a nonarthritic control population

1983 • 62 citations

Semiquantitative determination of cyanogen bromide peptides of collagen in SDS-polyacrylamide gels

1976 • 57 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in joint collagenous tissues

1979 • 54 citations

A mechanism for cartilage destruction in rheumatoid arthritis.

1970 • 50 citations

Immunity to Homologus Cartilage Proteoglycans in Rabbits with Chronic Inflammatory Arthritis

1981 • 47 citations

The Role of Soft Connective Tissue in the Breakdown of Pig Articular Cartilage Cultivated in the Presence of Complement-Sufficient Antiserum to Pig Erythrocytes

1973 • 46 citations

The effects of leucocyte elastase on the mechanical properties of adult human articular cartilage in tension

1981 • 46 citations

Changes in Proteoglycan and Collagen in Cartilage in Rheumatoid Arthritis

1978 • 46 citations

The localization of retinol-binding protein in rat liver by immunofluorescence microscopy

1975 • 45 citations

Characterisation of the Major CNBr-Derived Peptides of Porcine Type II Collagen

1975 • 37 citations

The capacity of pig articular cartilage in organ culture to regenerate after breakdown induced by complement-sufficient antiserum to pig erythrocytes

1976 • 27 citations

Immunity to homologous collagens and cartilage proteoglycans in rabbits.

1983 • 25 citations

Stimulation of collagenase secretion from rheumatoid synovial tissue by human collagen peptides.

1982 • 23 citations

The structural basis of cell-mediated immunological reactions of collagen. The species specificity of the cutaneous delayed hypersensitivity reaction.

1973 • 20 citations

Immunity to homologous type III collagen after partial meniscectomy and sham surgery in rabbits

1982 • 20 citations

Ultrastructure of synovio-cartilage junction in rheumatoid arthritis.

1973 • 18 citations

Connective tissue antigens stimulate collagenase production in arthritic diseases

1984 • 16 citations