Prostaglandin Endoperoxide H Synthases-1 and -2

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

1993 • 1,222 citations

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 • 1,133 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Peroxidases in chemistry and biology

1990 • 1,039 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

1994 • 862 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

1993 • 708 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

1991 • 580 citations

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

1995 • 574 citations

Prostanoid biosynthesis and mechanisms of action

1992 • 551 citations

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity

1993 • 546 citations

Characterization of inducible cyclooxygenase in rat brain

1995 • 539 citations

The retention signal for soluble proteins of the endoplasmic reticulum

1990 • 531 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Structure of the human cyclo-oxygenase-2 gene

1994 • 488 citations

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1995 • 483 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Nuclear factor kappa B, a mediator of lipopolysaccharide effects

1993 • 476 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

1994 • 462 citations

Cloning Two Isoforms of Rat Cyclooxygenase: Differential Regulation of Their Expression

1993 • 457 citations

Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′,5′-monophosphate, and theophylline

1968 • 456 citations

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

1976 • 435 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

1990 • 429 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.

1994 • 410 citations

On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α

1967 • 403 citations

Inhibition of prostaglandin biosynthesis

1974 • 402 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Identification and Characterization of a Prostaglandin Transporter

1995 • 400 citations

Characterization of the human gene (PTGS2) encoding prostaglandin‐endoperoxide synthase 2

1994 • 396 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1979 • 375 citations

Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

1994 • 366 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

1992 • 353 citations

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.

1994 • 352 citations

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1993 • 348 citations

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1994 • 339 citations

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

1994 • 337 citations

Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme

1989 • 333 citations

Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

1995 • 331 citations

Identification of a phorbol ester-repressible v-src-inducible gene.

1989 • 322 citations

Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.

1994 • 314 citations

Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles.

1992 • 312 citations

Movement of fatty acids, fatty acid analogs, and bile acids across phospholipid bilayers

1993 • 301 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.

1995 • 291 citations

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

1975 • 288 citations

Higher oxidation states of prostaglandin H synthase

1988 • 284 citations

Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

1983 • 277 citations

Prostaglandin H Synthase and Xenobiotic Oxidation

1990 • 276 citations

Role of inducible cyclooxygenase (COX-2) in inflammation.

1994 • 276 citations

Characterization of the Genomic Structure, Chromosomal Location and Promoter of Human Prostaglandin H Synthase-2 Gene

1994 • 272 citations

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

1989 • 265 citations

Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro.

1992 • 260 citations

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.

1994 • 260 citations

Higher oxidation states of prostaglandin H synthase

1988 • 254 citations

Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.

1994 • 243 citations

Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element.

1993 • 234 citations

Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex

1978 • 232 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Serum and Glucocorticoid Regulation of Gene Transcription and Expression of the Prostaglandin H Synthase-1 and Prostaglandin H Synthase-2 Isozymes

1993 • 224 citations

Comparison of Hydroperoxide Initiator Requirements for the Cyclooxygenase Activities of Prostaglandin H Synthase-1 and −2

1995 • 219 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.

1994 • 219 citations

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

1988 • 217 citations

Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities.

1987 • 217 citations

Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.

1992 • 212 citations

N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

1993 • 211 citations

Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

1993 • 210 citations

Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′-flanking regulatory sequences

1992 • 210 citations

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

1995 • 210 citations

Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo.

1994 • 209 citations

Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.

1993 • 208 citations

Prostaglandin Biosynthesis and its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 195 citations

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

1992 • 191 citations

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.

1994 • 187 citations

Phospholipase A2 and signal transduction.

1992 • 187 citations

Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets.

1994 • 186 citations

The cyclic AMP response element plays an essential role in the expression of the human prostaglandin‐endoperoxide synthase 2 gene in differentiated U937 monocytic cells

1994 • 185 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene.

1993 • 183 citations

Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1

1996 • 178 citations

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

1994 • 178 citations

Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions

1993 • 177 citations

The Use of Aspirin in Ischemic Heart Disease

1992 • 177 citations

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1980 • 174 citations

Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells.

1993 • 172 citations

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.

1993 • 171 citations

Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins.

1978 • 167 citations

Inhibition of Prostaglandin Biosynthesis

1976 • 165 citations

Prostaglandin Endoperoxide Synthase in Rat Ovarian Follicles: Content, Cellular Distribution, and Evidence for Hormonal Induction Preceding Ovulation*

1987 • 164 citations

Spectral properties of the higher oxidation states of prostaglandin H synthase.

1985 • 159 citations

Acetylation of Prostaglandin Endoperoxide Synthetase with Acetylsalicylic Acid

1980 • 158 citations

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

1989 • 156 citations

Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.

1993 • 155 citations

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

1995 • 149 citations

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

1983 • 148 citations

Prostaglandin endoperoxide synthase. The aspirin acetylation region.

1992 • 146 citations

Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor

1992 • 141 citations

Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset.

1995 • 138 citations

Prostaglandin G/H Synthase Isoenzyme 2 Expression in Fibroblasts - Regulation by Dexamethasone, Mitogens, and Oncogenes

1993 • 134 citations

Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities.

1982 • 134 citations

Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid

1995 • 134 citations

Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes.

1994 • 133 citations

Interaction Between Nitric Oxide and Prostaglandin H Synthase

1994 • 132 citations

Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells. Bradykinin, arginine vasopressin, prostaglandin E2 interrelationships.

1984 • 132 citations

Differentiation of Monocytoid THP-1 Cells with Phorbol Ester Induces Expression of Prostaglandin Endoperoxide Synthase-1 (COX-1)

1993 • 130 citations

Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells in culture

1981 • 130 citations

The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.

1994 • 129 citations

Human peritoneal mesothelial cell prostaglandin synthesis: Induction of cyclooxygenase mRNA by peritoneal macrophage-derived cytokines

1994 • 129 citations

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1992 • 129 citations

A carbon-centered free radical intermediate in the prostaglandin synthetase oxidation of arachidonic acid. Spin trapping and oxygen uptake studies.

1980 • 128 citations

Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

1983 • 126 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics.

1994 • 122 citations

The Catalytic Outcomes of the Constitutive and the Mitogen Inducible Isoforms of Prostaglandin H2 Synthase Are Markedly Affected by Glutathione and Glutathione Peroxidase(s)

1995 • 119 citations

Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae.

1994 • 117 citations

Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis

1994 • 116 citations

Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding.

1991 • 115 citations

Interleukin‐1β induces cytosolic phospholipase a₂ and prostaglandin h synthase in rheumatoid synovial fibroblasts

1994 • 112 citations

Selective Inhibition of Prostaglandin Endoperoxide Synthase-1 (Cyclooxygenase-1) by Valerylsalicylic Acid

1995 • 112 citations

Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression.

1994 • 110 citations

Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.

1994 • 108 citations

Interleukin‐1‐Induced Prostaglandin E₂ Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A₂ and Cyclooxygenase‐2

1994 • 108 citations

Heme spin states and peroxide-induced radical species in prostaglandin H synthase.

1987 • 108 citations

Orientation of the active site and antigenic determinants of prostaglandin endoperoxide synthase in the endoplasmic reticulum.

1981 • 108 citations

Subcellular Localization of Prostaglandin Endoperoxide Synthase-2 in Murine 3T3 Cells

1993 • 100 citations

Bimodal distribution of the prostaglandin I2 synthase antigen in smooth muscle cells.

1983 • 99 citations

Prostaglandins, Leukotrienes, Lipoxins, and PAF

1991 • 98 citations

Lipoxygenation activity of purified prostaglandin-forming cyclooxygenase

1978 • 95 citations

Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin

1990 • 95 citations

Sorting of membrane proteins in the yeast secretory pathway.

1994 • 95 citations

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.

1994 • 95 citations

Mutation of serine‐516 in human prostaglandin G/H synthase‐2 to methionine or aspirin acetylation of this residue stimulates 15‐R‐HETE synthesis

1994 • 94 citations

Rapid Induction of Prostaglandin Endoperoxide Synthase in Rat Preovulatory Follicles by Luteinizing Hormone and cAMP is Blocked by Inhibitors of Transcription and Translation

1989 • 92 citations

Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes.

1987 • 90 citations

Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.

1994 • 89 citations

Multiple Cyclooxygenases: Cloning of a Mitogen-Inducible Form

1991 • 89 citations

Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation

1994 • 89 citations

Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin

1977 • 88 citations

Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells.

1991 • 83 citations

Persistent induction of cyclooxygenase in p60v-src-transformed 3T3 fibroblasts.

1990 • 82 citations

Differentiation-associated expression of prostaglandin G/H synthase in monocytic cells

1993 • 80 citations

Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis.

1992 • 77 citations

Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.

1994 • 77 citations

Interleukin-1-Induced Prostaglandin E2 Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A2 and Cyclooxygenase-2

1994 • 76 citations

Prostaglandin H synthase: Distinct binding sites for cyclooxygenase and peroxidase substrates

1988 • 74 citations

Purification and Characterization of Recombinant Human Cyclooxygenase-2

1994 • 74 citations

Impermeability of rabbit erythrocytes to prostaglandins

1975 • 73 citations

Determination of the structure of the carbohydrate chains of prostaglandin endoperoxide synthase from sheep

2008 • 69 citations

Prostaglandin H synthase: Implications for membrane structure

1994 • 68 citations

The oxidation of arachidonic acid by the cyclooxygenase activity of purified prostaglandin H synthase: Spin trapping of a carbon-centered free radical intermediate

1986 • 67 citations

Nonsteroidal antiinflammatory drugs and human cancer. Report of an interdisciplinary research workshop

1994 • 63 citations

Topography of Prostaglandin H Synthase

1989 • 62 citations

Selective Induction of Prostaglandin G/H Synthase I by Stem Cell Factor and Dexamethasone in Mast Cells

1995 • 61 citations

Comparison of branched-chain and tightly coupled reaction mechanisms for prostaglandin H synthase

1995 • 57 citations

New Alzheimer's Therapy Suggested

1993 • 57 citations

Regulation of prostaglandin endoperoxide synthase gene expression in rat mesangial cells by interleukin-1 beta

1994 • 53 citations

Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo

1994 • 52 citations

Regulated expression of prostaglandin endoperoxide synthase-2 by uterine stroma.

1994 • 51 citations

Functional differentiation of cyclooxygenase and peroxidase activities of prostaglandin synthase by trypsin treatment. Possible location of a prosthetic heme binding site.

1988 • 49 citations

Characterization of a Tyrosyl Radical in Prostaglandin Endoperoxide Synthase-2

1994 • 47 citations

Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.

1992 • 43 citations

Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset

1995 • 43 citations

Epidermal growth factor coordinately regulates the expression of prostaglandin G/H synthase and cytosolic phospholipase A2 genes in embryonic mouse cells.

1994 • 42 citations

Prostaglandin endoperoxide synthase substituted with manganese protoporphyrin IX. Formation of a higher oxidation state and its relation to cyclooxygenase reaction.

1992 • 42 citations

[9] Purification of PGH synthase from sheep vesicular glands

1982 • 41 citations

Thromboxane biosynthesis in cardiovascular diseases.

1990 • 39 citations

Reciprocal regulation of human platelet cAMP levels by thromboxane A2 and prostacyclin.

1978 • 39 citations

Reduced pyridine nucleotides and cytochrome b5 as electron donors for prostaglandin synthetase reconstituted in dimyristyl phosphatidylcholine vesicles.

1982 • 36 citations

Retention of a type II surface membrane protein in the endoplasmic reticulum by the Lys-Asp-Glu-Leu sequence.

1992 • 35 citations

Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.

1993 • 34 citations

Enzymatic conversions of 10,10-difluoroarachidonic acid with PGH synthase and soybean lipoxygenase

1987 • 32 citations

The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase)

1993 • 32 citations

Time-dependent inhibition of platelet cyclo-oxygenase by indomethacin is slowly reversible

1986 • 31 citations

Turning down the heat: new routes to inhibition of inflammatory signaling by prostaglandin H2 synthases

1995 • 29 citations

Prostaglandin H Synthase-1: Evaluation of C-Terminus Function

1995 • 29 citations

Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae

1994 • 28 citations

Regulated expression of prostaglandin endoperoxide synthase-2 by uterine stroma

1994 • 28 citations

Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase

1991 • 28 citations

Localization of Prostaglandin Endoperoxide Synthase-1 to the Endoplasmic-Reticulum and Nuclear-Envelope Is Independent of Its C-Terminal Tetrapeptide-Ptel

1995 • 27 citations

Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial

1995 • 27 citations

Prostaglandin Endoperoxide Synthases

2010 • 23 citations

Prostaglandin endoperoxide synthase contains an EGF‐like domain

1989 • 23 citations

[30] Distribution of PGE and PGF2α receptor proteins in the intracellular organelles of bovine corpora lutea

1982 • 16 citations

Characterization of phospholipase A2 release by elicited-peritoneal macrophage and its relationship to eicosanoid production.

1994 • 14 citations

Prostaglandin Biosynthesis and Its Compartmentation in Vascular Smooth Muscle and Endothelial Cells

1986 • 13 citations

Deleted Work

1955 • 0 citations