Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src

1993 • 230 citations

Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′-flanking regulatory sequences

1992 • 210 citations

Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions

1993 • 177 citations

Interleukin-1-induced cyclooxygenase 2 expression is suppressed by cyclosporin A in rat mesangial cells

1994 • 176 citations

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.

1993 • 171 citations

Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells [published erratum appears in J Cell Biol 1990 Mar;110(3):863]

1989 • 170 citations

Mesangial cell turnover: effect of heparin and peptide growth factors.

1991 • 167 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

1988 • 148 citations

Structural Determination and Promoter Analysis of the Chicken Mitogen-Inducible Prostaglandin G/H Synthase Gene and Genetic Mapping of the Murine Homolog

1993 • 127 citations

Regulation of Prostaglandin H Synthase mRNA Levels and Prostaglandin Biosynthesis by Platelet-derived Growth Factor

1989 • 124 citations

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1989 • 122 citations

Regulation of eicosanoid biosynthesis in the macrophage

1993 • 100 citations

Phorbol Ester and Epidermal Growth Factor Enhance the Expression of Two Inducible Prostaglandin H Synthase Genes in Rat Tracheal Epithelial Cells

1993 • 96 citations

Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells.

1991 • 83 citations

Differential regulation of fos and jun gene expression and AP-1 cis-element activity by endothelin isopeptides. Possible implications for mitogenic signaling by endothelin.

1992 • 81 citations

Endothelin Peptides and the Kidney

1993 • 67 citations

Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells

1991 • 63 citations

Immunocharacterization of protein kinase C isoenzymes in rat kidney glomeruli, and cultured glomerular epithelial and mesangial cells.

1993 • 58 citations

Prostaglandins and rat glomerular mesangial cell proliferation

1990 • 52 citations

Regulation of Prostaglandin Endoperoxide Synthase Gene Expression in Cultured Rat Mesangial Cells: Induction by Serum via a Protein Kinase-C-Dependent Mechanism

1991 • 48 citations

Lipopolysaccharide-Induced Expression of Prostaglandin H Synthase-2 in Alveolar Macrophages Is Inhibited by Dexamethasone but Not by Aspirin

1993 • 44 citations

Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C‐regulated phospholipase D

1992 • 41 citations

Platelet‐activating factor stimulates multiple signaling pathways in cultured rat mesangial cells

1992 • 33 citations

Endothelin-1 Stimulates Cytosolic Phospholipase A2 in Chinese Hamster Ovary Cells Stably Expressing the Human ETA or ETB Receptor Subtype

1994 • 16 citations

Amplification of the Arachidonic Acid Cascade: Implications for Pharmacologic Intervention

1993 • 6 citations