The Catalytic Outcomes of the Constitutive and the Mitogen Inducible Isoforms of Prostaglandin H2 Synthase Are Markedly Affected by Glutathione and Glutathione Peroxidase(s)

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Oxygen Radicals and Human Disease

1987 • 1,854 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI.

1993 • 550 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids

1990 • 480 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Purification and characterization of human plasma glutathione peroxidase: A selenoglycoprotein distinct from the known cellular enzyme

1987 • 415 citations

Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.

1994 • 377 citations

Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

1994 • 366 citations

Phospholipid hydroperoxide glutathione peroxidase.

1986 • 337 citations

Regulation of Selenoproteins

1993 • 314 citations

Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

1983 • 277 citations

Higher oxidation states of prostaglandin H synthase

1988 • 254 citations

A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.

1990 • 247 citations

Constraints on prostaglandin biosynthesis in tissues.

1987 • 222 citations

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

1992 • 191 citations

Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake

1974 • 174 citations

Prostaglandin endoperoxide synthase. The aspirin acetylation region.

1992 • 146 citations

Dietary Selenium Intake Controls Rat Plasma Selenoprotein P Concentration

1989 • 136 citations

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

1986 • 134 citations

Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene.

1993 • 125 citations

Oxidant defense mechanisms in the human colon

1990 • 122 citations

Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics.

1994 • 122 citations

Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants.

1991 • 104 citations

Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase

1981 • 100 citations

[43] Cytochrome P-450 arachidonate oxygenase

1990 • 92 citations

Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase.

1986 • 74 citations

Arachidonic acid epoxidation: Epoxyeicosatrienoic acids are endogenous constituents of rat liver

1984 • 66 citations

16 Enzymes in the Biosynthesis and Catabolism of the Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes and Hydroxy Fatty Acids

1983 • 64 citations

The regulation of glutathione peroxidase gene expression relevant to species difference and the effects of dietary selenium manipulation

1989 • 50 citations

Regulation of endothelial cell prostaglandin synthesis by glutathione.

1991 • 49 citations

Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans.

1988 • 35 citations

The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters

1990 • 25 citations

[6] Quantification of 9α,11β-prostaglandin F2 by stable isotope dilution mass spectrometric assay

1990 • 24 citations

Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography

1992 • 19 citations

Changes in Tissue Levels of Glutathione, Extent of Lipid Peroxidation, and Activity of Glutathione Peroxidase in Transplantable Murine Lymphoma

1994 • 17 citations

Changes in Glutathione Peroxidase Activities and the Oxidative Burst of Leukocytes During Inflammation in the Mouse and Rat

1987 • 9 citations

Impairment of learning behavior in rats by nmda receptor antagonists radial maze and passive avoidance tests

1988 • 7 citations