Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

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1992 • 551 citations

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

1992 • 546 citations

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1991 • 545 citations

Regulation of arachidonic acid metabolites in macrophages.

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Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization.

1994 • 264 citations

Platelet-activating factor: a phospholipid autacoid with diverse actions

1993 • 253 citations

Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

1993 • 210 citations

Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

1993 • 206 citations

Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets.

1993 • 191 citations

Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.

1993 • 158 citations

Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.

1993 • 155 citations

Evidence that secretory phospholipase A2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells.

1994 • 132 citations

Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.

1992 • 114 citations

Inhibition Studies on the Membrane-associated Phospholipase A2 in vitro and Prostaglandin E2 Production in vivo of the Macrophage-like P388D1 Cell

1989 • 107 citations

Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen.

1993 • 101 citations

Pancreatic-type phospholipase A2 induces group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells.

1994 • 83 citations

Rapid remodeling of arachidonate from phosphatidylcholine to phosphatidylethanolamine pools during mast cell activation.

1992 • 83 citations

Release of 14‐kDa group‐II phospholipase A₂ from activated mast cells and its possible involvement in the regulation of the degranulation process

1992 • 82 citations

Interleukin‐1β and transforming growth factor‐β₂ enhance cytosolic high‐molecular‐mass phospholipase A₂ activity and induce prostaglandin E₂ formation in rat mesangial cells

1992 • 80 citations

Interleukin-1 beta- and forskolin-induced synthesis and secretion of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by transforming growth factor-beta 2.

1992 • 78 citations

Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release

1991 • 73 citations

Pathways for arachidonic acid mobilization in zymosan-stimulated mouse peritoneal macrophages

1992 • 70 citations

Participation in cellular prostaglandin synthesis of type‐II phospholipase A₂ secreted and anchored on cell‐surface heparan sulfate proteoglycan

1993 • 70 citations

Phospholipase activities of the P388D1 macrophage-like cell line

1985 • 65 citations

Mobilization of different arachidonate pools and their roles in the generation of leukotrienes and free arachidonic acid during immunologic activation of mast cells.

1993 • 65 citations

Phagocytosis of bacteria and phospholipid degradation

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Identification of Receptors for Platelet-Activating Factor in Rat Kupffer Cells

1989 • 52 citations

Tumor necrosis factor induces enhanced responses to platelet‐activating factor and differentiation in human monocytic Mono Mac 6 cells

1993 • 49 citations

Regulation of arachidonic acid release in vascular endothelium. Ca2+-dependent and -independent pathways

1991 • 37 citations

Increased incorporation of arachidonic acid into phospholipids in zymosan‐stimulated mouse peritoneal macrophages

1994 • 35 citations

Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells

1994 • 33 citations

Phosphorylation and activation of the arachidonate‐mobilizing phospholipase A₂ in macrophages in response to bacteria

1993 • 29 citations

Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.

1992 • 28 citations

Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx

1991 • 23 citations

Exogenous group II phospholipase A2 induces prostaglandin E2 production in mouse peritoneal macrophages

1994 • 23 citations

Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction

1991 • 21 citations

Mechanism of arachidonic acid liberation in ethanol-treated mouse peritoneal macrophages

1993 • 16 citations

Heterogeneity of arachidonate and paf-acether precursor pools in mast cells

1992 • 12 citations

Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages

1993 • 8 citations