Nitric oxide activates cyclooxygenase enzymes.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

1993 • 1,022 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

1975 • 932 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

Prostaglandin endoperoxide synthase: regulation of enzyme expression

1991 • 642 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Demonstration by EPR spectroscopy of the functional role of iron in soybean lipoxygenase-1

1975 • 300 citations

Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.

1988 • 269 citations

Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin

1992 • 254 citations

Nitric oxide mediates norepinephrine-induced prostaglandin E2 release from the hypothalamus.

1992 • 219 citations

The role of endothelium in the control of vascular tone

1985 • 202 citations

Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide.

1990 • 191 citations

Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1.

1985 • 142 citations

Optimized Conditions for the Growth of Human Epidermal Cells in Culture

1980 • 142 citations

Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts.

1988 • 85 citations

The endothelium-dependent vasodilator effect of acetylcholine: Characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism

1984 • 73 citations

EPR study of ferric native prostaglandin H synthase and its ferrous NO derivative

1987 • 70 citations

The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived.

1982 • 68 citations

Differential biosynthesis of prostaglandins by hydronephrotic rabbit and cat kidneys.

1981 • 61 citations

Endotoxin‐induced vasodilatation in anaesthetized rat skin involves nitric oxide and prostaglandin synthesis

1992 • 54 citations

Effect of vasodilators, including nitric oxide, on the release of cGMP and cAMP in the isolated perfused rat kidney

1992 • 53 citations

The metabolism of glyceryl trinitrate to nitric oxide in the macrophage cell line J774 and its induction by Escherichia coli lipopolysaccharide

1992 • 23 citations

Role of ferric iron in platelet lipoxygenase activity

1980 • 16 citations