Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Transformation in yeast: Development of a hybrid cloning vector and isolation of the can1 gene

1979 • 1,080 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase.

1982 • 558 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.

1989 • 451 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography

1980 • 301 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Genetic map of Saccharomyces cerevisiae, edition 9

1985 • 248 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Methylation-induced blocks to in vitro DNA replication

1985 • 220 citations

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase

1991 • 187 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

1990 • 144 citations

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.

1986 • 143 citations

Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.

1988 • 139 citations

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA

1990 • 130 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

1989 • 124 citations

cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.

1990 • 113 citations

Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.

1986 • 108 citations

Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase.

1990 • 104 citations

Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.

1991 • 101 citations

Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.

1979 • 101 citations

A Tn 10-lacZ-kanR-URA3 Gene Fusion Transposon for Insertion Mutagenesis and Fusion Analysis of Yeast and Bacterial Genes

1987 • 100 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

1988 • 89 citations

Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.

1990 • 84 citations

Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.

1990 • 84 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

Selection of functional cDNAs by complementation in yeast.

1983 • 73 citations

Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

1990 • 71 citations

Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

1990 • 68 citations

Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.

1984 • 64 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures

1985 • 52 citations

Bacillus subtilis adaoperon encodes two DNA alkyltransferases

1990 • 51 citations

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine

1983 • 50 citations

Adaptive resynthesis of O ⁶ -methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair

1982 • 45 citations

Response of S. cerevisiae to N-methyl-N′-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

1985 • 43 citations

Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli

1991 • 43 citations

O⁶-Methylguanine DNA methyltransferase activity in liver from various fish species

1987 • 40 citations

Properties and assay of mammalian O6-alkyguanine-DNA alkyltransferase

1987 • 40 citations

Induction of proteins involved in the repair of alkylated bases in mammalian cells by DNA-damaging agents

1990 • 39 citations

Bacillus subtilisgene coding for constitutiveO⁶-methylguanine-DNA alkyttransferase

1989 • 37 citations

Modulation of O6-methylguanine-DNA methyltransferase in rat and hamster liver after treatment with dimethylnitrosamine.

1990 • 28 citations

Repair of alkylated DNA: Drosophila have DNA methyltransferases but not DNA glycosylases

1983 • 27 citations

In vitro induction of O⁶-methylguanine-DNA methyltransferase in C3H/10T1/2 cells by X-rays is inhibited by nitrogen

1988 • 17 citations

Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.

1991 • 16 citations

O⁶-methylguanine in the SV40 origin of replication inhibits binding but increases unwinding by viral large T antigen

1990 • 6 citations

Repair of alkylation damage in Saccharomyces cerevisiae

1990 • 5 citations