Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli

1985 • 342 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

A new class of Escherichia coli recBC mutants: implications for the role of RecBC enzyme in homologous recombination.

1984 • 194 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Involvement of Recombination Genes in Growth and Viability of Escherichia coli K-12

1971 • 132 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.

1986 • 108 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

Construction and characterization of extrachromosomal probes for mutagenesis by carcinogens: site-specific incorporation of O6-methylguanine into viral and plasmid genomes.

1984 • 57 citations

Stereospecific removal of methyl phosphotriesters from DNA by anEscherichia coli ada⁺extract

1985 • 55 citations