Response of S. cerevisiae to N-methyl-N′-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

Cellular responses to DNA damage

1983 • 301 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines

1980 • 218 citations

Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea

1975 • 206 citations

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

1975 • 193 citations

Mutagenesis in Saccharomyces Cerevisiae

1982 • 181 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Mutagenic specificity: Reversion of iso-1-cytochrome c mutants of yeast

1973 • 157 citations

LACK OF CHEMICALLY INDUCED MUTATION IN REPAIR-DEFICIENT MUTANTS OF YEAST

1974 • 147 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

O⁶-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors

1984 • 137 citations

Identification and Mutational Relocation of the AUG Codon Initiating Translation of Iso-1-Cytochrome c in Yeast

1971 • 128 citations

Specific transcripts are elevated in Saccharomyces cerevisiae in response to DNA damage.

1984 • 111 citations

Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA.

1980 • 99 citations

[16] Cloning regulated yeast genes from a pool of lacZ fusions

1983 • 96 citations

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents

1978 • 95 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

The effects of “Cell age” upon the lethal effects of physical and chemical mutagens in the yeast, Saccharomyces cerevisiae

1976 • 77 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.

1984 • 64 citations

Abilities of extracts of human lymphocytes to remove O6-methylguanine from DNA

1982 • 62 citations

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine

1983 • 50 citations

Adaptive resynthesis of O ⁶ -methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair

1982 • 45 citations

Lack of induction of O⁶-methylguanine-DNA methyltransferase in mammalian cells treated with N-methyl-N' -nitro-N-nitrosoguanidine

1984 • 43 citations

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1983 • 40 citations

Adaptive increase of O⁶-methlguanine-acceptor protein in HeLa cells following N-methyl-N′-nitro-N-nitrosoguanidine treatment

1982 • 38 citations

Specific Transcripts Are Elevated in Saccharomyces cerevisiae in Response to DNA Damage

1984 • 36 citations

Cellular Defense Mechanisms Against Alkylation of DNA

1982 • 31 citations

An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts

1982 • 27 citations

Adaptive response to simple alkylating agents in Bacillus subtilis cells

1983 • 26 citations

Adaptive response orMicrococcus luteusto alkylating chemlcals

1984 • 23 citations

Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O⁶-methylguanine in liver DNA

1981 • 22 citations

DNA repair: A laboratory manual of research procedures, vol. 3

1989 • 19 citations

Further studies on the induction of mutation in Haemophilus influenzae by N-methyl-N′-nitro-N-nitrosoguanidine: Lack of an inducible error-free repair system and the effect of exposure medium

1980 • 17 citations

Adaptive Doses of MNNG Efficiently Induce arecA-trpGene Fusion

1983 • 5 citations