Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

1966 • 2,239 citations

A gas-liquid solid phase peptide and protein sequenator.

1981 • 2,238 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Molecular Mechanisms for Repair of DNA

1975 • 676 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Genetic studies of the lac repressor

1977 • 610 citations

A new acid hydrolysis method for determining tryptophan in peptides and proteins

1974 • 609 citations

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

1974 • 495 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

<italic>Brief Communication:</italic> Carcinogenicity of N-Methyl-N-nitrosourea: Possible Role of Excision Repair of O<sup>6</sup>-Methylguanine From DNA

1974 • 182 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA

1990 • 130 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.

1986 • 125 citations

Cloning of theE. coliO⁶-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay

1985 • 124 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.

1990 • 113 citations

Repair of O-alkylpyrimidines in mammalian cells: a present consensus.

1988 • 104 citations

A simplified assay for O⁶-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

1984 • 104 citations

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.

1984 • 97 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.

1986 • 82 citations

Purification of theE.coliogt gene product to homogeneity and its rate of action onO⁶-methylguanine,O⁶-ethyiguanine andO⁴-methylthymine in dodecadeoxyribnucleotides

1989 • 81 citations

[4] The calculation of partial specific volumes of proteins in 6 M guanidine hydrochloride

1979 • 61 citations

Functional sites of the Ada regulatory protein of Escherichia coli

1988 • 59 citations

Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.

1986 • 46 citations

Human O⁶-alkylguanine-DNA alkyltransferase fails to repair O⁴-methylthymine and methyl phosphotriesters in DNA as efficiently as does the alkyltransferase from Escherichia coli

1985 • 44 citations

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

1984 • 44 citations

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.

1990 • 42 citations

Affinity purification and characterization of humanO⁶-alkylguanine-DNA aikyltransferase complexed with BCNU-treated, synthetic oligonudeotide

1989 • 41 citations

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1983 • 40 citations

Comparison of repair of O⁶-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells

1984 • 38 citations

Extent of formation of O⁴-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O⁶-alkylguanine-DNA-alkyltransferase

1985 • 33 citations

Repair of O⁴-methyldeoxythymidine residues in DNA by mammalian liver extracts

1985 • 32 citations

Repair of DNA lesions introduced by N-nitroso compounds

1986 • 30 citations

Active site amino acid sequence of the bovineO⁶-methylguanine-DNA methyltransferase

1990 • 19 citations

Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O⁶-methylguanine

1990 • 18 citations

Purification to apparent homogeneity and partial amino acid sequence of rat liverO⁶-alkylguanine-DNA-alkyltransferase

1990 • 18 citations

Purification of the human O⁶‐methylguanine‐DNA methyltransferase and uracil‐DNA glycosylase, the latter to apparent homogeneity

1988 • 11 citations