Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Dideoxy sequencing method using denatured plasmid templates

1986 • 1,537 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

α-Skeletal and α-Cardiac Actin Genes Are Coexpressed in Adult Human Skeletal Muscle and Heart

1983 • 237 citations

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

1984 • 236 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells.

1988 • 193 citations

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

1981 • 183 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

1985 • 137 citations

O6-Alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

1989 • 122 citations

Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

1988 • 89 citations

Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.

1982 • 88 citations

Purification and characterization of ribulose-5-phosphate kinase from spinach

1986 • 86 citations

Similar amino acid sequences revisited

1989 • 49 citations

Lack of induction of O⁶-methylguanine-DNA methyltransferase in mammalian cells treated with N-methyl-N' -nitro-N-nitrosoguanidine

1984 • 43 citations

Molecular Cloning and Biological Characterization of a Human Gene, ERCC2, that Corrects the Nucleotide Excision Repair Defect in CHO UV5 Cells

1988 • 42 citations

Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice

1989 • 41 citations

DNA-Mediated Transfer and Expression of a Human DNA Repair Gene That Demethylates O⁶-Methylguanine

1985 • 34 citations

O6-methylguanine-DNA methyltransferase in human fetal tissues: fetal and maternal factors.

1987 • 34 citations

Heterogeneity of O6-alkylguanine-DNA alkyltransferase activity in peripheral blood lymphocytes: relationship between this activity in lymphocytes and in lymphoblastoid lines from normal controls and from patients with Hodgkin's disease or non-Hodgkin's lymphoma.

1989 • 19 citations

Rapid, large-scale purification and characterization of ‘Ada protein’ (0⁶methylguanine-DNA methyltransferase) ofE.coli

1988 • 18 citations

Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization.

1982 • 14 citations

DNA repair in human cells: from genetic complementation to isolation of genes.

1988 • 9 citations

High-level expression of the cloned ada gene of Escherichia coli by deletion of its regulatory sequence

1988 • 5 citations

Regulation of the Capacity forO⁶-Methylguanine Removal from DNA in Human Lymphoblastoid Cells Studied by Cell Hybridization

1982 • 2 citations

Trials, costs and complications.

1988 • 1 citations