Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

PROTEINASE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 460 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines

1980 • 218 citations

ISOLATION AND CHARACTERIZATION OF MMS-SENSITIVE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 216 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

1986 • 187 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase

1980 • 146 citations

Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.

1988 • 139 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

1989 • 124 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Repair of O-alkylpyrimidines in mammalian cells: a present consensus.

1988 • 104 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

A second DNA methyltransferase repair enzyme in Escherichia coli.

1988 • 77 citations

Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae

1989 • 77 citations

Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.

1984 • 64 citations

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium

1989 • 60 citations

Isolation and purification of O6-Alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

1985 • 59 citations

The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures

1985 • 52 citations

Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease.

1989 • 51 citations

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine

1983 • 50 citations

O⁶-Methylguanine methyltransferase activity is increased in rat tissues by ionising radiation

1985 • 49 citations

Genetic complementation of UV-induced DNA repair in Chinese hamster ovary cells by the denV gene of phage T4.

1985 • 47 citations

DNA repair in normal human and xeroderma pigmentosum group A fibroblasts following treatment with various methanesulfonates and the demonstration of a long-patch (u.v.-like) repair component

1982 • 46 citations

Human O⁶-alkylguanine-DNA alkyltransferase fails to repair O⁴-methylthymine and methyl phosphotriesters in DNA as efficiently as does the alkyltransferase from Escherichia coli

1985 • 44 citations

Response of S. cerevisiae to N-methyl-N′-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

1985 • 43 citations

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.

1989 • 42 citations

Intranuclear distribution of DNA repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts.

1974 • 41 citations

Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells

1983 • 40 citations

O⁶-Methylguanine DNA methyltransferase activity in liver from various fish species

1987 • 40 citations

Properties and assay of mammalian O6-alkyguanine-DNA alkyltransferase

1987 • 40 citations

Adaptive increase of O⁶-methlguanine-acceptor protein in HeLa cells following N-methyl-N′-nitro-N-nitrosoguanidine treatment

1982 • 38 citations

Bacteriophage T4 genetic homologies with bacteria and eucaryotes

1989 • 38 citations

Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.

1982 • 29 citations

Repair of alkylated DNA: Drosophila have DNA methyltransferases but not DNA glycosylases

1983 • 27 citations

Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response

1986 • 22 citations

Yeast gene RAD52 can substitute for phage T4 gene 46 or 47 in carrying out recombination and DNA repair.

1988 • 16 citations

Views of unity and diversity

1988 • 11 citations

denV gene of bacteriophage T4 restores DNA excision repair to mei-9 and mus201 mutants of Drosophila melanogaster.

1989 • 10 citations