Bacillus subtilis adaoperon encodes two DNA alkyltransferases

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE

1958 • 1,827 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

1990 • 292 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

The intracellular signal for induction of resistance to alkylating agents in E. coli

1986 • 222 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Developmental and genetic regulation of bacillus subtilis genes transcribed by σ28-RNA polymerase

1983 • 195 citations

A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate

1983 • 175 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Characterisation and nucleotide sequence ofogt, the O⁶-alkyiguanine-DNA-alkyltransferase gene ofE.coli

1987 • 163 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Arabinose C Protein: Regulation of the Arabinose Operon in vitro

1971 • 154 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Cloning of theE. coliO⁶-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay

1985 • 124 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.

1986 • 108 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor

1989 • 94 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

The araC gene of Escherichia coli: Transcriptional and translational start-points and complete nucleotide sequence

1980 • 67 citations

Molecular cloning and characterization of the alkB gene of Escherichia coli

1985 • 66 citations

Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.

1986 • 58 citations

DNA sequence of the araC regulatory gene from Escherichia coli B/r

1980 • 52 citations

Expression of the ada gene of Escherichia coli in response to alkylating agents

1988 • 41 citations

Bacillus subtilisgene coding for constitutiveO⁶-methylguanine-DNA alkyttransferase

1989 • 37 citations

Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents

1987 • 30 citations

MutantEscherichia coliAda proteins simultaneously defective in the repair of O⁶-metbylguanine and in gene activation

1986 • 28 citations

The nucleotide sequence of the araC regulatory gene in Salmonella typhimurium LT2

1982 • 26 citations

Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada− cells

1989 • 24 citations

Alteration of the carboxyl-terminal domain of Ada protein influences its inducibility, specificity, and strength as a transcriptional activator

1988 • 21 citations

Polyclonal antibodies against O6-methylguanine-DNA methyltransferase in adapted bacteria

1988 • 19 citations

Further studies on the induction of mutation in Haemophilus influenzae by N-methyl-N′-nitro-N-nitrosoguanidine: Lack of an inducible error-free repair system and the effect of exposure medium

1980 • 17 citations

Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents

1985 • 14 citations

Two classes of Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents

1986 • 13 citations