Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment

The Hallmarks of Cancer

2000 • 27,569 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

2003 • 3,098 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

The STATs of cancer — new molecular targets come of age

2004 • 2,232 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Putting tumours in context

2001 • 2,145 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

The multistep nature of cancer

1993 • 1,872 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

2005 • 988 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

2006 • 891 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

2005 • 737 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 • 705 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

The BRAF–MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells

2006 • 647 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

Cancer Immunotherapy: A Treatment for the Masses

2004 • 610 citations

Suppressors of cytokine signaling and immunity

2003 • 607 citations

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

2005 • 553 citations

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

2003 • 540 citations

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

2004 • 539 citations

Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells

2006 • 525 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

2003 • 502 citations

IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation

2004 • 487 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

2004 • 458 citations

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

2003 • 441 citations

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

2001 • 436 citations

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

2005 • 431 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Regulation of gene-activation pathways by PIAS proteins in the immune system

2005 • 422 citations

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

2002 • 421 citations

STAT3 is a potential modulator of HIF‐1‐mediated VEGF expression in human renal carcinoma cells

2005 • 406 citations

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity

2003 • 389 citations

A Critical Role for Stat3 Signaling in Immune Tolerance

2003 • 388 citations

Role of Stat3 in Regulating p53 Expression and Function

2005 • 381 citations

Activation of Stat3 in Human Melanoma Promotes Brain Metastasis

2006 • 378 citations

Plasmacytoid Dendritic Cells Induce CD8+ Regulatory T Cells In Human Ovarian Carcinoma

2005 • 376 citations

Stat3 regulates genes common to both wound healing and cancer

2005 • 371 citations

Spinning molecular immunology into successful immunotherapy

2002 • 364 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

2005 • 336 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Regulation of Dendritic Cell Differentiation and Antitumor Immune Response in Cancer by Pharmacologic-Selective Inhibition of the Janus-Activated Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway

2005 • 308 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

2000 • 295 citations

The IL-6R α chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo

2005 • 295 citations

Targeting STAT3 affects melanoma on multiple fronts

2005 • 278 citations

Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity

2004 • 261 citations

Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

2005 • 259 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

1999 • 247 citations

STAT signaling in the pathogenesis and treatment of leukemias

2000 • 242 citations

The role of STATs in myeloid differentiation and leukemia

2000 • 230 citations

Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10

2006 • 223 citations

Tumour escape from immune surveillance through dendritic cell inactivation

2002 • 221 citations

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

2006 • 217 citations

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

2003 • 207 citations

IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells

2005 • 201 citations

Protein microarrays for multiplex analysis of signal transduction pathways

2004 • 199 citations

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity

2004 • 186 citations

Studies of IFN-Induced Transcriptional Activation Uncover the Jak-Stat Pathway

1998 • 173 citations

Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma

2004 • 169 citations

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

1994 • 152 citations

A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells

2005 • 151 citations

Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

2006 • 147 citations

STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells

2004 • 146 citations

Immunotherapy: Bewitched, Bothered, and Bewildered No More

2004 • 136 citations

Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects

2005 • 132 citations

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

2003 • 130 citations

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

2001 • 127 citations

Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6

2004 • 112 citations

Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer

2005 • 103 citations

Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma

2005 • 103 citations

IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 • 102 citations

Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3

2005 • 94 citations

Immunotherapy: target the stroma to hit the tumor

2005 • 86 citations

Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis

2004 • 84 citations

Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells

2001 • 83 citations

STAT3 activation is required for Asp816 mutant c-Kit induced tumorigenicity

2001 • 83 citations

Distinct and Overlapping Roles of Interleukin-10 and CD25+ Regulatory T Cells in the Inhibition of Antitumor CD8 T-Cell Responses

2005 • 66 citations

Full Oncogenic Activities of v-Src Are Mediated by Multiple Signaling Pathways

2000 • 66 citations

A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells

2005 • 59 citations

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein

2005 • 54 citations

An oligonucleotide decoy for Stat3 activates the immune response of macrophages to breast cancer

2006 • 50 citations

IL-2 Overcomes the Unresponsiveness but Fails to Reverse the Regulatory Function of Antigen-Induced T Regulatory Cells

2005 • 34 citations