Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma

World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues

2002 • 4,781 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

1994 • 2,375 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 712 citations

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

1997 • 703 citations

STAT proteins: novel molecular targets for cancer drug discovery

2000 • 634 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

1997 • 516 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Prognostic Significance of Anaplastic Lymphoma Kinase (ALK) Protein Expression in Adults With Anaplastic Large Cell Lymphoma

1999 • 487 citations

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

2003 • 441 citations

Prognostic Significance of Anaplastic Lymphoma Kinase (ALK) Protein Expression in Adults With Anaplastic Large Cell Lymphoma

1999 • 422 citations

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

2002 • 421 citations

The molecular basis and potential role of survivin in cancer diagnosis and therapy

2001 • 407 citations

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

2002 • 389 citations

Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

1999 • 385 citations

Role of the Nucleophosmin (NPM) Portion of the Non-Hodgkin’s Lymphoma-Associated NPM-Anaplastic Lymphoma Kinase Fusion Protein in Oncogenesis

1997 • 371 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Nucleophosmin-Anaplastic Lymphoma Kinase of Large-Cell Anaplastic Lymphoma Is a Constitutively Active Tyrosine Kinase That Utilizes Phospholipase C-γ To Mediate Its Mitogenicity

1998 • 281 citations

Translocations involving anaplastic lymphoma kinase (ALK)

2001 • 279 citations

Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma

2002 • 273 citations

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

2001 • 248 citations

Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

1998 • 238 citations

Negative regulators of cytokine signal transduction

1999 • 224 citations

STAT3 is constitutively activated in Hodgkin cell lines

2001 • 220 citations

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

1999 • 196 citations

Arginine/Lysine-rich Nuclear Localization Signals Mediate Interactions between Dimeric STATs and Importin α5

2002 • 172 citations

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart

2002 • 151 citations

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

2001 • 131 citations

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

1999 • 115 citations

Interleukin-11 Up-Regulates Survivin Expression in Endothelial Cells through a Signal Transducer and Activator of Transcription-3 Pathway

2001 • 114 citations

Lack of the t(2;5) or other mutations resulting in expression of anaplastic lymphoma kinase catalytic domain in CD30+ primary cutaneous lymphoproliferative disorders and Hodgkin's disease

1996 • 70 citations

STAT3 Down-regulates the Expression of Cyclin D during Liver Development

2002 • 67 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 44 citations