Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1998 • 513 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

1997 • 444 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

1996 • 372 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3

1997 • 325 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.

1994 • 301 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.

1995 • 267 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.

1996 • 240 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

1994 • 233 citations

Expression of c-met is a strong independent prognostic factor in breast carcinoma

1998 • 210 citations

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

1994 • 203 citations

Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells

1999 • 197 citations

Structural and functional characterization of the mouse hepatocyte growth factor gene promoter.

1994 • 161 citations

c-Src Kinase Activity Is Required for Hepatocyte Growth Factor-induced Motility and Anchorage-independent Growth of Mammary Carcinoma Cells

1998 • 156 citations

Expression of the C-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression

1997 • 153 citations

Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents

1998 • 140 citations

Pathways Downstream of Shc and Grb2 Are Required for Cell Transformation by the Tpr-Met Oncoprotein

1996 • 129 citations

Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.

1993 • 125 citations

Role of morphogenetic factors in metastasis of mammary carcinoma cells

1998 • 122 citations

Regulation of mammary gland factor/Stat5a during mammary gland development.

1995 • 119 citations

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

1997 • 116 citations

Co-expression of theHGF/SF andc-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis

1996 • 115 citations

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

1996 • 112 citations

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

2000 • 111 citations

Inefficient Membrane Targeting, Translocation, and Proteolytic Processing by Signal Peptidase of a Mutant Preproparathyroid Hormone Protein

1995 • 106 citations

Significance of circulating hepatocyte growth factor level as a prognostic indicator in primary breast cancer.

1998 • 86 citations

Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines

1999 • 85 citations

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.

1995 • 78 citations

Regulation of the Src protein tyrosine kinase

1995 • 69 citations

c-Src Activates both STAT1 and STAT3 in PDGF-Stimulated NIH3T3 Cells

1997 • 68 citations

Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma.

1996 • 66 citations

Phosphatidylinositol 3-Kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells

1996 • 56 citations

A Novel Transcriptional Regulatory Region within the Core Promoter of the Hepatocyte Growth Factor Gene Is Responsible for Its Inducibility by Cytokines via the C/EBP Family of Transcription Factors

1997 • 56 citations

Transcriptional Regulation of the Hepatocyte Growth Factor Gene by the Nuclear Receptors Chicken Ovalbumin Upstream Promoter Transcription Factor and Estrogen Receptor

1997 • 42 citations

Transcriptional Regulation of Sertoli Cell Immediate Early Genes by Interleukin-6 and Interferon-γ Is Mediated through Phosphorylation of STAT-3 and STAT-1 Proteins*

1997 • 42 citations

Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors

1997 • 39 citations

Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor

1993 • 38 citations

Expression of RET 3′ splicing variants during human kidney development

1998 • 37 citations

Jak-STAT pathway is involved in the induction ofTNF-β gene during stimulation by IL-2

1998 • 36 citations

Expression of v-src in mammary epithelial cells induces transcription via STAT3

1998 • 34 citations

Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells.

1996 • 33 citations

Cooperative effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for phosphatidylinositol 3-kinase activity.

2000 • 31 citations

Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor gene.

1994 • 30 citations

Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.

1993 • 21 citations

The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservation

1994 • 19 citations

Human S mu binding protein-2 binds to the drug response element and transactivates the human apoA-I promoter: role of gemfibrozil

1998 • 17 citations

The Upstream Regulatory Regions of the Hepatocyte Growth Factor Gene Promoter Are Essential for Its Expression in Transgenic Mice

1998 • 16 citations

Hepatocyte Growth Factor (HGF) Is a Copper-Binding Protein: A Facile Probe for Purification of HGF by Immobilized Cu(II)-Affinity Chromatography

1996 • 11 citations